Oxidative stress and inflammatory signaling in cerulein pancreatitis

Ji Hoon Yu, Hye Young Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Oxidative stress is considered to be an important regulator of the pathogenesis of acute pancreatitis. Reactive oxygen species (ROS) regulate the activation of inflammatory cascades, the recruitment of inflammatory cells and tissue damage in acute pancreatitis. A hallmark of the inflammatory response in pancreatitis is the induction of cytokine expression, which is regulated by a number of signaling molecules including oxidant-sensitive transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein kinases (MAPKs). Cross-talk between ROS and pro-inflammatory cytokines is mediated by NF-κB, AP-1, STAT3, and MAPKs; this crosstalk amplifies the inflammatory cascade in acute pancreatitis. Therapeutic studies have shown that antioxidants and natural compounds can have beneficial effects for patients with pancreatitis and can also influence the expression of proinflammatory cytokines in cerulein-in-duced pancreatitis. Since oxidative stress may activate inflammatory signaling pathways and contribute to the development of pancreatitis, antioxidant therapy may alleviate the symptoms or prevent the development of pancreatitis. Since chronic administration of high doses of antioxidants may have deleterious effects, dosage levels and duration of antioxidant treatment should be carefully determined.

Original languageEnglish
Pages (from-to)17324-17329
Number of pages6
JournalWorld Journal of Gastroenterology
Volume20
Issue number46
DOIs
Publication statusPublished - 2014 Dec 14

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Ceruletide
Pancreatitis
Oxidative Stress
Antioxidants
STAT3 Transcription Factor
Transcription Factor AP-1
Cytokines
Mitogen-Activated Protein Kinases
Reactive Oxygen Species
Oxidants
Transcription Factors
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

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Oxidative stress and inflammatory signaling in cerulein pancreatitis. / Yu, Ji Hoon; Kim, Hye Young.

In: World Journal of Gastroenterology, Vol. 20, No. 46, 14.12.2014, p. 17324-17329.

Research output: Contribution to journalArticle

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