P110β in the ventromedial hypothalamus regulates glucose and energy metabolism

Teppei Fujikawa, Yun Hee Choi, Dong Joo Yang, Dong Min Shin, Jose Donato, Daisuke Kohno, Charlotte E. Lee, Carol F. Elias, Syann Lee, Ki Woo Kim

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Abstract

Phosphoinositide 3-kinase (PI3K) signaling in hypothalamic neurons integrates peripheral metabolic cues, including leptin and insulin, to coordinate systemic glucose and energy homeostasis. PI3K is composed of different subunits, each of which has several unique isoforms. However, the role of the PI3K subunits and isoforms in the ventromedial hypothalamus (VMH), a prominent site for the regulation of glucose and energy homeostasis, is unclear. Here we investigated the role of subunit p110β in steroidogenic factor-1 (SF-1) neurons of the VMH in the regulation of metabolism. Our data demonstrate that the deletion of p110β in SF-1 neurons disrupts glucose metabolism, rendering the mice insulin resistant. In addition, the deletion of p110β in SF-1 neurons leads to the whitening of brown adipose tissues and increased susceptibility to diet-induced obesity due to blunted energy expenditure. These results highlight a critical role for p110β in the regulation of glucose and energy homeostasis via VMH neurons.

Original languageEnglish
Article number52
JournalExperimental and Molecular Medicine
Volume51
Issue number4
DOIs
Publication statusPublished - 2019 Apr 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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    Fujikawa, T., Choi, Y. H., Yang, D. J., Shin, D. M., Donato, J., Kohno, D., Lee, C. E., Elias, C. F., Lee, S., & Kim, K. W. (2019). P110β in the ventromedial hypothalamus regulates glucose and energy metabolism. Experimental and Molecular Medicine, 51(4), [52]. https://doi.org/10.1038/s12276-019-0249-8