P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma

Taeyeong Kim; Soon Hee Jung; Soo Ki Kim; Hyeong Ju Kwon

doi:10.1007/s13273-019-0017-9

P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma

Taeyeong Kim, Soon Hee Jung, Soo Ki Kim, Hyeong Ju Kwon

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Backgrounds: Human papilloma virus (HPV) infection is an important factor in development and prognosis of head and neck squamous cell carcinoma (HNSCC). It is also known that HPV infection could affect anti-cancer immunity. Methods: We examined the association between cancer immunity-related molecules and HPV infection, using immunohistochemical (IHC) staining for p16, PD-L1, and FOXP3 and real-time polymerase chain reaction for HPV. Results: The IHC staining for PD-L1 was positive in 30 out of 122 cases (24.6%) and p16 showed positivity in 68 out of 122 cases (55.7%). HPV was detected in 48 out of 122 cases (39.3%). P16 expression was significantly associated with PD-L1 expression (P=0.004), HPV infection (P=0.032), and the number of FOXP3-positive tumor infiltrating lymphocytes (P=0.009). PD-L1-positive or p16-positive HNSCC showed a worse prognosis than PD-L1-negative or p16-negative HNSCC. Conclusion: P16 expression may predict PD-L1 expression, and p16 expression may also be associated with the immune evasion of HNSCC.

Original language	English
Pages (from-to)	137-143
Number of pages	7
Journal	Molecular and Cellular Toxicology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s13273-019-0017-9
Publication status	Published - 2019 Apr 1

Bibliographical note

Funding Information:
Acknowledgements This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education (NRF-2016R1C1B1015129). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology
Pharmacology, Toxicology and Pharmaceutics(all)
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma",

abstract = "Backgrounds: Human papilloma virus (HPV) infection is an important factor in development and prognosis of head and neck squamous cell carcinoma (HNSCC). It is also known that HPV infection could affect anti-cancer immunity. Methods: We examined the association between cancer immunity-related molecules and HPV infection, using immunohistochemical (IHC) staining for p16, PD-L1, and FOXP3 and real-time polymerase chain reaction for HPV. Results: The IHC staining for PD-L1 was positive in 30 out of 122 cases (24.6%) and p16 showed positivity in 68 out of 122 cases (55.7%). HPV was detected in 48 out of 122 cases (39.3%). P16 expression was significantly associated with PD-L1 expression (P=0.004), HPV infection (P=0.032), and the number of FOXP3-positive tumor infiltrating lymphocytes (P=0.009). PD-L1-positive or p16-positive HNSCC showed a worse prognosis than PD-L1-negative or p16-negative HNSCC. Conclusion: P16 expression may predict PD-L1 expression, and p16 expression may also be associated with the immune evasion of HNSCC.",

author = "Taeyeong Kim and Jung, {Soon Hee} and Kim, {Soo Ki} and Kwon, {Hyeong Ju}",

note = "Funding Information: Acknowledgements This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education (NRF-2016R1C1B1015129). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.",

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doi = "10.1007/s13273-019-0017-9",

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AU - Kim, Soo Ki

AU - Kwon, Hyeong Ju

N1 - Funding Information: Acknowledgements This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education (NRF-2016R1C1B1015129). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Backgrounds: Human papilloma virus (HPV) infection is an important factor in development and prognosis of head and neck squamous cell carcinoma (HNSCC). It is also known that HPV infection could affect anti-cancer immunity. Methods: We examined the association between cancer immunity-related molecules and HPV infection, using immunohistochemical (IHC) staining for p16, PD-L1, and FOXP3 and real-time polymerase chain reaction for HPV. Results: The IHC staining for PD-L1 was positive in 30 out of 122 cases (24.6%) and p16 showed positivity in 68 out of 122 cases (55.7%). HPV was detected in 48 out of 122 cases (39.3%). P16 expression was significantly associated with PD-L1 expression (P=0.004), HPV infection (P=0.032), and the number of FOXP3-positive tumor infiltrating lymphocytes (P=0.009). PD-L1-positive or p16-positive HNSCC showed a worse prognosis than PD-L1-negative or p16-negative HNSCC. Conclusion: P16 expression may predict PD-L1 expression, and p16 expression may also be associated with the immune evasion of HNSCC.

AB - Backgrounds: Human papilloma virus (HPV) infection is an important factor in development and prognosis of head and neck squamous cell carcinoma (HNSCC). It is also known that HPV infection could affect anti-cancer immunity. Methods: We examined the association between cancer immunity-related molecules and HPV infection, using immunohistochemical (IHC) staining for p16, PD-L1, and FOXP3 and real-time polymerase chain reaction for HPV. Results: The IHC staining for PD-L1 was positive in 30 out of 122 cases (24.6%) and p16 showed positivity in 68 out of 122 cases (55.7%). HPV was detected in 48 out of 122 cases (39.3%). P16 expression was significantly associated with PD-L1 expression (P=0.004), HPV infection (P=0.032), and the number of FOXP3-positive tumor infiltrating lymphocytes (P=0.009). PD-L1-positive or p16-positive HNSCC showed a worse prognosis than PD-L1-negative or p16-negative HNSCC. Conclusion: P16 expression may predict PD-L1 expression, and p16 expression may also be associated with the immune evasion of HNSCC.

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P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma

Abstract

Bibliographical note

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UN SDGs

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