P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma

Taeyeong Kim, Soon Hee Jung, Soo-Ki Kim, Hyeong Ju Kwon

Research output: Contribution to journalArticle

Abstract

Backgrounds: Human papilloma virus (HPV) infection is an important factor in development and prognosis of head and neck squamous cell carcinoma (HNSCC). It is also known that HPV infection could affect anti-cancer immunity. Methods: We examined the association between cancer immunity-related molecules and HPV infection, using immunohistochemical (IHC) staining for p16, PD-L1, and FOXP3 and real-time polymerase chain reaction for HPV. Results: The IHC staining for PD-L1 was positive in 30 out of 122 cases (24.6%) and p16 showed positivity in 68 out of 122 cases (55.7%). HPV was detected in 48 out of 122 cases (39.3%). P16 expression was significantly associated with PD-L1 expression (P=0.004), HPV infection (P=0.032), and the number of FOXP3-positive tumor infiltrating lymphocytes (P=0.009). PD-L1-positive or p16-positive HNSCC showed a worse prognosis than PD-L1-negative or p16-negative HNSCC. Conclusion: P16 expression may predict PD-L1 expression, and p16 expression may also be associated with the immune evasion of HNSCC.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalMolecular and Cellular Toxicology
Volume15
Issue number2
DOIs
Publication statusPublished - 2019 Apr 1

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Papillomaviridae
Tumor-Infiltrating Lymphocytes
Lymphocytes
Viruses
Tumors
Virus Diseases
Immunity
Staining and Labeling
Immune Evasion
Polymerase chain reaction
Carcinoma, squamous cell of head and neck
Epithelial Cells
Real-Time Polymerase Chain Reaction
Neoplasms
Molecules

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

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title = "P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma",
abstract = "Backgrounds: Human papilloma virus (HPV) infection is an important factor in development and prognosis of head and neck squamous cell carcinoma (HNSCC). It is also known that HPV infection could affect anti-cancer immunity. Methods: We examined the association between cancer immunity-related molecules and HPV infection, using immunohistochemical (IHC) staining for p16, PD-L1, and FOXP3 and real-time polymerase chain reaction for HPV. Results: The IHC staining for PD-L1 was positive in 30 out of 122 cases (24.6{\%}) and p16 showed positivity in 68 out of 122 cases (55.7{\%}). HPV was detected in 48 out of 122 cases (39.3{\%}). P16 expression was significantly associated with PD-L1 expression (P=0.004), HPV infection (P=0.032), and the number of FOXP3-positive tumor infiltrating lymphocytes (P=0.009). PD-L1-positive or p16-positive HNSCC showed a worse prognosis than PD-L1-negative or p16-negative HNSCC. Conclusion: P16 expression may predict PD-L1 expression, and p16 expression may also be associated with the immune evasion of HNSCC.",
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P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma. / Kim, Taeyeong; Jung, Soon Hee; Kim, Soo-Ki; Kwon, Hyeong Ju.

In: Molecular and Cellular Toxicology, Vol. 15, No. 2, 01.04.2019, p. 137-143.

Research output: Contribution to journalArticle

TY - JOUR

T1 - P16 expression and its association with PD-L1 expression and FOXP3-positive tumor infiltrating lymphocytes in head and neck squamous cell carcinoma

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AU - Kwon, Hyeong Ju

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Backgrounds: Human papilloma virus (HPV) infection is an important factor in development and prognosis of head and neck squamous cell carcinoma (HNSCC). It is also known that HPV infection could affect anti-cancer immunity. Methods: We examined the association between cancer immunity-related molecules and HPV infection, using immunohistochemical (IHC) staining for p16, PD-L1, and FOXP3 and real-time polymerase chain reaction for HPV. Results: The IHC staining for PD-L1 was positive in 30 out of 122 cases (24.6%) and p16 showed positivity in 68 out of 122 cases (55.7%). HPV was detected in 48 out of 122 cases (39.3%). P16 expression was significantly associated with PD-L1 expression (P=0.004), HPV infection (P=0.032), and the number of FOXP3-positive tumor infiltrating lymphocytes (P=0.009). PD-L1-positive or p16-positive HNSCC showed a worse prognosis than PD-L1-negative or p16-negative HNSCC. Conclusion: P16 expression may predict PD-L1 expression, and p16 expression may also be associated with the immune evasion of HNSCC.

AB - Backgrounds: Human papilloma virus (HPV) infection is an important factor in development and prognosis of head and neck squamous cell carcinoma (HNSCC). It is also known that HPV infection could affect anti-cancer immunity. Methods: We examined the association between cancer immunity-related molecules and HPV infection, using immunohistochemical (IHC) staining for p16, PD-L1, and FOXP3 and real-time polymerase chain reaction for HPV. Results: The IHC staining for PD-L1 was positive in 30 out of 122 cases (24.6%) and p16 showed positivity in 68 out of 122 cases (55.7%). HPV was detected in 48 out of 122 cases (39.3%). P16 expression was significantly associated with PD-L1 expression (P=0.004), HPV infection (P=0.032), and the number of FOXP3-positive tumor infiltrating lymphocytes (P=0.009). PD-L1-positive or p16-positive HNSCC showed a worse prognosis than PD-L1-negative or p16-negative HNSCC. Conclusion: P16 expression may predict PD-L1 expression, and p16 expression may also be associated with the immune evasion of HNSCC.

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