TY - JOUR
T1 - p38 Mitogen-Activated Protein Kinase Modulates Expression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induced by Interferon-γ in Fetal Brain Astrocytes
AU - Lee, J.
AU - Shin, J. S.
AU - Park, J. Y.
AU - Kwon, D.
AU - Choi, S. J.
AU - Kim, S. J.
AU - Choi, In Hong
PY - 2003/12/15
Y1 - 2003/12/15
N2 - This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes.
AB - This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes.
UR - http://www.scopus.com/inward/record.url?scp=0345412007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345412007&partnerID=8YFLogxK
U2 - 10.1002/jnr.10815
DO - 10.1002/jnr.10815
M3 - Article
C2 - 14648593
AN - SCOPUS:0345412007
VL - 74
SP - 884
EP - 890
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
SN - 0360-4012
IS - 6
ER -