Abstract
This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 884-890 |
| Number of pages | 7 |
| Journal | Journal of Neuroscience Research |
| Volume | 74 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2003 Dec 15 |
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All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
Cite this
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p38 Mitogen-Activated Protein Kinase Modulates Expression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induced by Interferon-γ in Fetal Brain Astrocytes. / Lee, Jongeun; Shin, J. S.; Park, J. Y.; Kwon, D.; Choi, S. J.; Kim, S. J.; Choi, In Hong.
In: Journal of Neuroscience Research, Vol. 74, No. 6, 15.12.2003, p. 884-890.Research output: Contribution to journal › Article
TY - JOUR
T1 - p38 Mitogen-Activated Protein Kinase Modulates Expression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induced by Interferon-γ in Fetal Brain Astrocytes
AU - Lee, Jongeun
AU - Shin, J. S.
AU - Park, J. Y.
AU - Kwon, D.
AU - Choi, S. J.
AU - Kim, S. J.
AU - Choi, In Hong
PY - 2003/12/15
Y1 - 2003/12/15
N2 - This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes.
AB - This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes.
UR - http://www.scopus.com/inward/record.url?scp=0345412007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345412007&partnerID=8YFLogxK
U2 - 10.1002/jnr.10815
DO - 10.1002/jnr.10815
M3 - Article
C2 - 14648593
AN - SCOPUS:0345412007
VL - 74
SP - 884
EP - 890
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
SN - 0360-4012
IS - 6
ER -