p38 Mitogen-Activated Protein Kinase Modulates Expression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induced by Interferon-γ in Fetal Brain Astrocytes

Jongeun Lee, J. S. Shin, J. Y. Park, D. Kwon, S. J. Choi, S. J. Kim, In Hong Choi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes.

Original languageEnglish
Pages (from-to)884-890
Number of pages7
JournalJournal of Neuroscience Research
Volume74
Issue number6
DOIs
Publication statusPublished - 2003 Dec 15

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p38 Mitogen-Activated Protein Kinases
Astrocytes
Interferons
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
TNF-Related Apoptosis-Inducing Ligand
Brain
Phosphorylation
Protein Kinase Inhibitors
Cytokines
SB 203580

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

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title = "p38 Mitogen-Activated Protein Kinase Modulates Expression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induced by Interferon-γ in Fetal Brain Astrocytes",
abstract = "This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes.",
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p38 Mitogen-Activated Protein Kinase Modulates Expression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induced by Interferon-γ in Fetal Brain Astrocytes. / Lee, Jongeun; Shin, J. S.; Park, J. Y.; Kwon, D.; Choi, S. J.; Kim, S. J.; Choi, In Hong.

In: Journal of Neuroscience Research, Vol. 74, No. 6, 15.12.2003, p. 884-890.

Research output: Contribution to journalArticle

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