Palpable breast masses with probably benign morphology at sonography: Can biopsy be deferred?

Y. M. Park, Eunkyung Kim, J. H. Lee, J. H. Ryu, S. S. Han, S. J. Choi, S. J. Lee, H. K. Yoon

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: When a palpable breast mass is detected, a biopsy is usually performed even if the mass reveals probably benign morphologic features on imaging, as there is relatively little data reporting the outcome of such breast masses. Purpose: To determine the negative predictive value for sonographic evaluation of palpable breast masses with probably benign morphology, and to assess whether follow-up may be an acceptable alternative to immediate biopsy. Material and Methods: Of the 1399 sonograms of palpable masses from January 2004 to September 2005, there were 397 patients with masses of probably benign morphology. This study included 274 of these patients (age range 12-64 years, mean age 34 years) with 312 palpable masses that were pathologically confirmed by fine-needle aspiration (n=7), ultrasound (US)-guided core needle biopsy (n=180), or surgical biopsy (n=125). The false-negative rate, negative predictive value (NPV), and 95% confidence interval (CI) were calculated using the SPSS statistical software package for Windows, version 12.0. A P value <0.05 was considered statistically significant. Results: Of the 312 masses, there were 310 benign lesions and two malignancies, resulting in a false-negative rate of 0.6% (NPV 99.4%, P value=0.0432, 95% CI 0.0-1.5%). Conclusion: The negative predictive value of sonography for palpable breast masses with probably benign morphology is high (99.4%). Therefore, short-term imaging follow-up can be an acceptable alternative to immediate biopsy, similar to the management of nonpalpable probably benign lesions (BI-RADS category 3).

Original languageEnglish
Pages (from-to)1104-1111
Number of pages8
JournalActa Radiologica
Volume49
Issue number10
DOIs
Publication statusPublished - 2008 Dec 1

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Ultrasonography
Breast
Biopsy
Confidence Intervals
Large-Core Needle Biopsy
Fine Needle Biopsy
Research Design
Software
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Park, Y. M., Kim, E., Lee, J. H., Ryu, J. H., Han, S. S., Choi, S. J., ... Yoon, H. K. (2008). Palpable breast masses with probably benign morphology at sonography: Can biopsy be deferred? Acta Radiologica, 49(10), 1104-1111. https://doi.org/10.1080/02841850802438504
Park, Y. M. ; Kim, Eunkyung ; Lee, J. H. ; Ryu, J. H. ; Han, S. S. ; Choi, S. J. ; Lee, S. J. ; Yoon, H. K. / Palpable breast masses with probably benign morphology at sonography : Can biopsy be deferred?. In: Acta Radiologica. 2008 ; Vol. 49, No. 10. pp. 1104-1111.
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abstract = "Background: When a palpable breast mass is detected, a biopsy is usually performed even if the mass reveals probably benign morphologic features on imaging, as there is relatively little data reporting the outcome of such breast masses. Purpose: To determine the negative predictive value for sonographic evaluation of palpable breast masses with probably benign morphology, and to assess whether follow-up may be an acceptable alternative to immediate biopsy. Material and Methods: Of the 1399 sonograms of palpable masses from January 2004 to September 2005, there were 397 patients with masses of probably benign morphology. This study included 274 of these patients (age range 12-64 years, mean age 34 years) with 312 palpable masses that were pathologically confirmed by fine-needle aspiration (n=7), ultrasound (US)-guided core needle biopsy (n=180), or surgical biopsy (n=125). The false-negative rate, negative predictive value (NPV), and 95{\%} confidence interval (CI) were calculated using the SPSS statistical software package for Windows, version 12.0. A P value <0.05 was considered statistically significant. Results: Of the 312 masses, there were 310 benign lesions and two malignancies, resulting in a false-negative rate of 0.6{\%} (NPV 99.4{\%}, P value=0.0432, 95{\%} CI 0.0-1.5{\%}). Conclusion: The negative predictive value of sonography for palpable breast masses with probably benign morphology is high (99.4{\%}). Therefore, short-term imaging follow-up can be an acceptable alternative to immediate biopsy, similar to the management of nonpalpable probably benign lesions (BI-RADS category 3).",
author = "Park, {Y. M.} and Eunkyung Kim and Lee, {J. H.} and Ryu, {J. H.} and Han, {S. S.} and Choi, {S. J.} and Lee, {S. J.} and Yoon, {H. K.}",
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Park, YM, Kim, E, Lee, JH, Ryu, JH, Han, SS, Choi, SJ, Lee, SJ & Yoon, HK 2008, 'Palpable breast masses with probably benign morphology at sonography: Can biopsy be deferred?', Acta Radiologica, vol. 49, no. 10, pp. 1104-1111. https://doi.org/10.1080/02841850802438504

Palpable breast masses with probably benign morphology at sonography : Can biopsy be deferred? / Park, Y. M.; Kim, Eunkyung; Lee, J. H.; Ryu, J. H.; Han, S. S.; Choi, S. J.; Lee, S. J.; Yoon, H. K.

In: Acta Radiologica, Vol. 49, No. 10, 01.12.2008, p. 1104-1111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Palpable breast masses with probably benign morphology at sonography

T2 - Can biopsy be deferred?

AU - Park, Y. M.

AU - Kim, Eunkyung

AU - Lee, J. H.

AU - Ryu, J. H.

AU - Han, S. S.

AU - Choi, S. J.

AU - Lee, S. J.

AU - Yoon, H. K.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Background: When a palpable breast mass is detected, a biopsy is usually performed even if the mass reveals probably benign morphologic features on imaging, as there is relatively little data reporting the outcome of such breast masses. Purpose: To determine the negative predictive value for sonographic evaluation of palpable breast masses with probably benign morphology, and to assess whether follow-up may be an acceptable alternative to immediate biopsy. Material and Methods: Of the 1399 sonograms of palpable masses from January 2004 to September 2005, there were 397 patients with masses of probably benign morphology. This study included 274 of these patients (age range 12-64 years, mean age 34 years) with 312 palpable masses that were pathologically confirmed by fine-needle aspiration (n=7), ultrasound (US)-guided core needle biopsy (n=180), or surgical biopsy (n=125). The false-negative rate, negative predictive value (NPV), and 95% confidence interval (CI) were calculated using the SPSS statistical software package for Windows, version 12.0. A P value <0.05 was considered statistically significant. Results: Of the 312 masses, there were 310 benign lesions and two malignancies, resulting in a false-negative rate of 0.6% (NPV 99.4%, P value=0.0432, 95% CI 0.0-1.5%). Conclusion: The negative predictive value of sonography for palpable breast masses with probably benign morphology is high (99.4%). Therefore, short-term imaging follow-up can be an acceptable alternative to immediate biopsy, similar to the management of nonpalpable probably benign lesions (BI-RADS category 3).

AB - Background: When a palpable breast mass is detected, a biopsy is usually performed even if the mass reveals probably benign morphologic features on imaging, as there is relatively little data reporting the outcome of such breast masses. Purpose: To determine the negative predictive value for sonographic evaluation of palpable breast masses with probably benign morphology, and to assess whether follow-up may be an acceptable alternative to immediate biopsy. Material and Methods: Of the 1399 sonograms of palpable masses from January 2004 to September 2005, there were 397 patients with masses of probably benign morphology. This study included 274 of these patients (age range 12-64 years, mean age 34 years) with 312 palpable masses that were pathologically confirmed by fine-needle aspiration (n=7), ultrasound (US)-guided core needle biopsy (n=180), or surgical biopsy (n=125). The false-negative rate, negative predictive value (NPV), and 95% confidence interval (CI) were calculated using the SPSS statistical software package for Windows, version 12.0. A P value <0.05 was considered statistically significant. Results: Of the 312 masses, there were 310 benign lesions and two malignancies, resulting in a false-negative rate of 0.6% (NPV 99.4%, P value=0.0432, 95% CI 0.0-1.5%). Conclusion: The negative predictive value of sonography for palpable breast masses with probably benign morphology is high (99.4%). Therefore, short-term imaging follow-up can be an acceptable alternative to immediate biopsy, similar to the management of nonpalpable probably benign lesions (BI-RADS category 3).

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