Pancreaticoduodenectomy of pancreatic ductal adenocarcinoma in the elderly

Chang Moo Kang, Jun Young Kim, Gi Hong Choi, Kyung Sik Kim, Kyung Sik Choi, Woo Jung Lee, Byong Ro Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: Pancreatic ductal adenocarcinoma has the highest incidence between the ages of 60 and 70 years. As the elderly population has been increasing in the last several decades, the proportion of patients older than 70 years of age with resectable pancreatic cancer is expected to increase in our society. This retrospective observation was performed to evaluate surgical value of pancreaticoduodenectomy for the elderly patients with pancreatic ductal adenocarcinoma. Materials and Methods: From January 1990 to June 2005, among the patients who underwent pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, the elder patients older than 70 years of age were retrospectively reviewed. Perioperative surgical outcomes, including general clinicopathologic features, morbidity, mortality, and survival outcomes, were investigated based on available medical records. Results: Seventy-seven patients underwent pancreaticoduodenenctomy (PD) for pancreatic ductal adenocarcinoma. Among them, 11 patients (14.3%) were 70 years older. More frequent incidences of morbidity (8 out of 11 vs. 25 out of 65, p = 0.049), especially delayed gastric emptying (3 out of 8 vs. 3 out of 66, p = 0.035), were observed and overall length of hospital stay was also longer in the elderly (49.2 ± 13.9 days vs. 36.1 ± 13.2, p = 0.012). However, no significant differences in mortality rate and survival outcomes were noted when comparing with those of the younger patients (p > 0.05). Conclusion: We agree with the opinion that age factor can not be absolute contraindication for pancreaticoduodenectomy, however, appropriate preoperative evaluations, proper patient selection considering life expectancy, advanced surgical techniques and detailed perioperative management are mandatory to guarantee the safety of pancreaticoduodenectomy performed in the elderly with pancreatic ductal adenocarcinoma.

Original languageEnglish
Pages (from-to)488-494
Number of pages7
JournalYonsei medical journal
Volume48
Issue number3
DOIs
Publication statusPublished - 2007 Jun 1

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Pancreaticoduodenectomy
Adenocarcinoma
Length of Stay
Morbidity
Survival
Mortality
Gastric Emptying
Age Factors
Incidence
Life Expectancy
Pancreatic Neoplasms
Patient Selection
Medical Records
Observation
Safety
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kang, C. M., Kim, J. Y., Choi, G. H., Kim, K. S., Choi, K. S., Lee, W. J., & Kim, B. R. (2007). Pancreaticoduodenectomy of pancreatic ductal adenocarcinoma in the elderly. Yonsei medical journal, 48(3), 488-494. https://doi.org/10.3349/ymj.2007.48.3.488
Kang, Chang Moo ; Kim, Jun Young ; Choi, Gi Hong ; Kim, Kyung Sik ; Choi, Kyung Sik ; Lee, Woo Jung ; Kim, Byong Ro. / Pancreaticoduodenectomy of pancreatic ductal adenocarcinoma in the elderly. In: Yonsei medical journal. 2007 ; Vol. 48, No. 3. pp. 488-494.
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abstract = "Purpose: Pancreatic ductal adenocarcinoma has the highest incidence between the ages of 60 and 70 years. As the elderly population has been increasing in the last several decades, the proportion of patients older than 70 years of age with resectable pancreatic cancer is expected to increase in our society. This retrospective observation was performed to evaluate surgical value of pancreaticoduodenectomy for the elderly patients with pancreatic ductal adenocarcinoma. Materials and Methods: From January 1990 to June 2005, among the patients who underwent pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, the elder patients older than 70 years of age were retrospectively reviewed. Perioperative surgical outcomes, including general clinicopathologic features, morbidity, mortality, and survival outcomes, were investigated based on available medical records. Results: Seventy-seven patients underwent pancreaticoduodenenctomy (PD) for pancreatic ductal adenocarcinoma. Among them, 11 patients (14.3{\%}) were 70 years older. More frequent incidences of morbidity (8 out of 11 vs. 25 out of 65, p = 0.049), especially delayed gastric emptying (3 out of 8 vs. 3 out of 66, p = 0.035), were observed and overall length of hospital stay was also longer in the elderly (49.2 ± 13.9 days vs. 36.1 ± 13.2, p = 0.012). However, no significant differences in mortality rate and survival outcomes were noted when comparing with those of the younger patients (p > 0.05). Conclusion: We agree with the opinion that age factor can not be absolute contraindication for pancreaticoduodenectomy, however, appropriate preoperative evaluations, proper patient selection considering life expectancy, advanced surgical techniques and detailed perioperative management are mandatory to guarantee the safety of pancreaticoduodenectomy performed in the elderly with pancreatic ductal adenocarcinoma.",
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Kang, CM, Kim, JY, Choi, GH, Kim, KS, Choi, KS, Lee, WJ & Kim, BR 2007, 'Pancreaticoduodenectomy of pancreatic ductal adenocarcinoma in the elderly', Yonsei medical journal, vol. 48, no. 3, pp. 488-494. https://doi.org/10.3349/ymj.2007.48.3.488

Pancreaticoduodenectomy of pancreatic ductal adenocarcinoma in the elderly. / Kang, Chang Moo; Kim, Jun Young; Choi, Gi Hong; Kim, Kyung Sik; Choi, Kyung Sik; Lee, Woo Jung; Kim, Byong Ro.

In: Yonsei medical journal, Vol. 48, No. 3, 01.06.2007, p. 488-494.

Research output: Contribution to journalArticle

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T1 - Pancreaticoduodenectomy of pancreatic ductal adenocarcinoma in the elderly

AU - Kang, Chang Moo

AU - Kim, Jun Young

AU - Choi, Gi Hong

AU - Kim, Kyung Sik

AU - Choi, Kyung Sik

AU - Lee, Woo Jung

AU - Kim, Byong Ro

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Purpose: Pancreatic ductal adenocarcinoma has the highest incidence between the ages of 60 and 70 years. As the elderly population has been increasing in the last several decades, the proportion of patients older than 70 years of age with resectable pancreatic cancer is expected to increase in our society. This retrospective observation was performed to evaluate surgical value of pancreaticoduodenectomy for the elderly patients with pancreatic ductal adenocarcinoma. Materials and Methods: From January 1990 to June 2005, among the patients who underwent pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, the elder patients older than 70 years of age were retrospectively reviewed. Perioperative surgical outcomes, including general clinicopathologic features, morbidity, mortality, and survival outcomes, were investigated based on available medical records. Results: Seventy-seven patients underwent pancreaticoduodenenctomy (PD) for pancreatic ductal adenocarcinoma. Among them, 11 patients (14.3%) were 70 years older. More frequent incidences of morbidity (8 out of 11 vs. 25 out of 65, p = 0.049), especially delayed gastric emptying (3 out of 8 vs. 3 out of 66, p = 0.035), were observed and overall length of hospital stay was also longer in the elderly (49.2 ± 13.9 days vs. 36.1 ± 13.2, p = 0.012). However, no significant differences in mortality rate and survival outcomes were noted when comparing with those of the younger patients (p > 0.05). Conclusion: We agree with the opinion that age factor can not be absolute contraindication for pancreaticoduodenectomy, however, appropriate preoperative evaluations, proper patient selection considering life expectancy, advanced surgical techniques and detailed perioperative management are mandatory to guarantee the safety of pancreaticoduodenectomy performed in the elderly with pancreatic ductal adenocarcinoma.

AB - Purpose: Pancreatic ductal adenocarcinoma has the highest incidence between the ages of 60 and 70 years. As the elderly population has been increasing in the last several decades, the proportion of patients older than 70 years of age with resectable pancreatic cancer is expected to increase in our society. This retrospective observation was performed to evaluate surgical value of pancreaticoduodenectomy for the elderly patients with pancreatic ductal adenocarcinoma. Materials and Methods: From January 1990 to June 2005, among the patients who underwent pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, the elder patients older than 70 years of age were retrospectively reviewed. Perioperative surgical outcomes, including general clinicopathologic features, morbidity, mortality, and survival outcomes, were investigated based on available medical records. Results: Seventy-seven patients underwent pancreaticoduodenenctomy (PD) for pancreatic ductal adenocarcinoma. Among them, 11 patients (14.3%) were 70 years older. More frequent incidences of morbidity (8 out of 11 vs. 25 out of 65, p = 0.049), especially delayed gastric emptying (3 out of 8 vs. 3 out of 66, p = 0.035), were observed and overall length of hospital stay was also longer in the elderly (49.2 ± 13.9 days vs. 36.1 ± 13.2, p = 0.012). However, no significant differences in mortality rate and survival outcomes were noted when comparing with those of the younger patients (p > 0.05). Conclusion: We agree with the opinion that age factor can not be absolute contraindication for pancreaticoduodenectomy, however, appropriate preoperative evaluations, proper patient selection considering life expectancy, advanced surgical techniques and detailed perioperative management are mandatory to guarantee the safety of pancreaticoduodenectomy performed in the elderly with pancreatic ductal adenocarcinoma.

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