Panelcomposer

A web-based panel construction tool for multivariate analysis of disease biomarker candidates

Seul Ki Jeong, Keun Na, Kwang Youl Kim, Hoguen Kim, Young-Ki Paik

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Measuring and evaluating diagnostic efficiency is important in biomarker discovery and validation. The receiver operating characteristic (ROC) curve is a graphical plot for assessing the performance of a classifier or predictor that can be used to test the sensitivity and specificity of diagnostic biomarkers. In this study, we describe PanelComposer, a Web-based software tool that uses statistical results from proteomic expression data and validates biomarker candidates based on ROC curves and the area under the ROC curve (AUC) values using a logistic regression model and provides an ordered list that includes ROC graphs and AUC values for proteins (individually or in combination). This tool allows users to easily compare and assess the effectiveness and diagnostic efficiency of single or multiprotein biomarker candidates. PanelComposer is available publicly at http://panelcomposer.proteomix.org/ and is compatible with major Web browsers.

Original languageEnglish
Pages (from-to)6277-6281
Number of pages5
JournalJournal of Proteome Research
Volume11
Issue number12
DOIs
Publication statusPublished - 2012 Dec 7

Fingerprint

Biomarkers
ROC Curve
Multivariate Analysis
Area Under Curve
Logistic Models
Web Browser
Web browsers
Logistics
Classifiers
Proteomics
Software
Sensitivity and Specificity
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)

Cite this

Jeong, Seul Ki ; Na, Keun ; Kim, Kwang Youl ; Kim, Hoguen ; Paik, Young-Ki. / Panelcomposer : A web-based panel construction tool for multivariate analysis of disease biomarker candidates. In: Journal of Proteome Research. 2012 ; Vol. 11, No. 12. pp. 6277-6281.
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Panelcomposer : A web-based panel construction tool for multivariate analysis of disease biomarker candidates. / Jeong, Seul Ki; Na, Keun; Kim, Kwang Youl; Kim, Hoguen; Paik, Young-Ki.

In: Journal of Proteome Research, Vol. 11, No. 12, 07.12.2012, p. 6277-6281.

Research output: Contribution to journalArticle

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