Panosialins, inhibitors of enoyl-ACP reductase from Streptomyces sp. AN1761

Yun Ju Kwon, Mi Jin Sohn, Taegwon Oh, Sang Nae Cho, Chang Jin Kim, Won Gon Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the continued search for inhibitors of enoyl-acyl carrier protein (ACP) reductase, we found that four acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761 potently inhibited bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis. Their structures were identified as panosialins A, B, wA, and wB by MS and NMR data. They showed stronger inhibition against S. aureus FabI and S. pneumoniae FabK with IC50 of 3-5 μM than M. tuberculosis InhA with IC50 of 9-12 μM. They also exhibited a stronger antibacterial spectrum on S. aureus and S. pneumoniae than M. tuberculosis. In addition, the higher inhibitory activity of panosialin wB than panosialin B on fatty acid biosynthesis was consistent with that on bacterial growth, suggesting that they could exert their antibacterial activity by inhibiting fatty acid synthesis.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalJournal of microbiology and biotechnology
Volume23
Issue number2
DOIs
Publication statusPublished - 2013 Feb

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

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