Paper-based bioactive scaffolds for stem cell-mediated bone tissue engineering

Hyun Ji Park, Seung Jung Yu, Kisuk Yang, Yoonhee Jin, Ann Na Cho, Jin Kim, Bora Lee, Hee Seok Yang, Sung Gap Im, Seung Woo Cho

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91 Citations (Scopus)


Bioactive, functional scaffolds are required to improve the regenerative potential of stem cells for tissue reconstruction and functional recovery of damaged tissues. Here, we report a paper-based bioactive scaffold platform for stem cell culture and transplantation for bone reconstruction. The paper scaffolds are surface-engineered by an initiated chemical vapor deposition process for serial coating of a water-repellent and cell-adhesive polymer film, which ensures the long-term stability in cell culture medium and induces efficient cell attachment. The prepared paper scaffolds are compatible with general stem cell culture and manipulation techniques. An optimal paper type is found to provide structural, physical, and mechanical cues to enhance the osteogenic differentiation of human adipose-derived stem cells (hADSCs). A bioactive paper scaffold significantly enhances in vivo bone regeneration of hADSCs in a critical-sized calvarial bone defect. Stacking the paper scaffolds with osteogenically differentiated hADSCs and human endothelial cells resulted in vascularized bone formation in vivo. Our study suggests that paper possesses great potential as a bioactive, functional, and cost-effective scaffold platform for stem cell-mediated bone tissue engineering. To the best of our knowledge, this is the first study reporting the feasibility of a paper material for stem cell application to repair tissue defects.

Original languageEnglish
Pages (from-to)9811-9823
Number of pages13
Issue number37
Publication statusPublished - 2014 Dec 1

Bibliographical note

Funding Information:
This work was supported by a grant ( HI13C1479 ) from the Korea Health Technology R&D Project funded by the Ministry of Health and Welfare, Republic of Korea . This work was also supported by a grant ( 2009-0083522 ) from the Translational Research Center for Protein Function Control (TRCP) funded by the Ministry of Science, ICT and Future Planning (MSIP), Republic of Korea . This work was supported by the Advanced Biomass R&D Center (ABC) of the Global Frontier Project funded by the Ministry of Education, Science and Technology ( ABC-2011-0031356 ). This study was partially supported by National Agenda Project (NAP) funded by the Korea Research Council of Fundamental Science & Technology ( NAP-09-04 ).

Publisher Copyright:
© 2014 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Ceramics and Composites
  • Biomaterials
  • Mechanics of Materials


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