Papillary carcinoma located in the thyroid isthmus

Yong Sang Lee, Jong Ju Jeong, Kee Hyun Nam, Woong Youn Chung, Hang Seok Chang, Cheong Soo Park

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The purpose of the present study was to evaluate the clinicopathologic characteristics and short-term outcomes of papillary thyroid carcinomas (PTC) located in the isthmus compared to tumors located in other thyroid regions, and to use those findings to establish a surgical strategy for treating these tumors. Patients and methods: Thyroidectomy was performed in 1,973 thyroid cancer patients in our hospital between January 2006 and December 2007. The patients were analyzed in two groups; group I, patients with tumors located in the isthmus (n = 181) and group II, patients with tumors located in other thyroid regions (n = 1,792). The clinicopathologic characteristics and short-term outcomes were compared between the two groups. Results: The study groups were similar in terms of age and gender ratio. For groups I and II, respectively, the mean primary tumor size was 1.02 cm and 1.13 cm (p = 0.017), capsular invasion frequency was 70.2 and 60.8% (p = 0.008), and multifocality frequency was 48.6 and 39.8% (p = 0.006). In addition, central node involvement was 40.3 and 42.1% (p = 0.350), and lateral node involvement was 9.4 and 18.2% (p = 0.001). At the time of postoperative iodine-131 remnant ablation, 34.3% of group I patients and 38.0% of group II patients showed undetectable serum thyroglobulin concentrations. There were no significant differences in surgical complications between the two groups. Conclusions: Papillary thyroid carcinomas located in the isthmus was more likely to be associated with multiple foci in bilateral lobes and higher rates of capsular invasions than tumors in other thyroid regions. These findings indicate that total thyroidectomy is an appropriate initial surgical procedure for the isthmic PTC.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalWorld Journal of Surgery
Volume34
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

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Papillary Carcinoma
Thyroid Gland
Neoplasms
Thyroidectomy
Thyroglobulin
Thyroid Neoplasms
Iodine
Serum
Papillary Thyroid cancer

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Lee, Y. S., Jeong, J. J., Nam, K. H., Chung, W. Y., Chang, H. S., & Park, C. S. (2010). Papillary carcinoma located in the thyroid isthmus. World Journal of Surgery, 34(1), 36-39. https://doi.org/10.1007/s00268-009-0298-6
Lee, Yong Sang ; Jeong, Jong Ju ; Nam, Kee Hyun ; Chung, Woong Youn ; Chang, Hang Seok ; Park, Cheong Soo. / Papillary carcinoma located in the thyroid isthmus. In: World Journal of Surgery. 2010 ; Vol. 34, No. 1. pp. 36-39.
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abstract = "Background: The purpose of the present study was to evaluate the clinicopathologic characteristics and short-term outcomes of papillary thyroid carcinomas (PTC) located in the isthmus compared to tumors located in other thyroid regions, and to use those findings to establish a surgical strategy for treating these tumors. Patients and methods: Thyroidectomy was performed in 1,973 thyroid cancer patients in our hospital between January 2006 and December 2007. The patients were analyzed in two groups; group I, patients with tumors located in the isthmus (n = 181) and group II, patients with tumors located in other thyroid regions (n = 1,792). The clinicopathologic characteristics and short-term outcomes were compared between the two groups. Results: The study groups were similar in terms of age and gender ratio. For groups I and II, respectively, the mean primary tumor size was 1.02 cm and 1.13 cm (p = 0.017), capsular invasion frequency was 70.2 and 60.8{\%} (p = 0.008), and multifocality frequency was 48.6 and 39.8{\%} (p = 0.006). In addition, central node involvement was 40.3 and 42.1{\%} (p = 0.350), and lateral node involvement was 9.4 and 18.2{\%} (p = 0.001). At the time of postoperative iodine-131 remnant ablation, 34.3{\%} of group I patients and 38.0{\%} of group II patients showed undetectable serum thyroglobulin concentrations. There were no significant differences in surgical complications between the two groups. Conclusions: Papillary thyroid carcinomas located in the isthmus was more likely to be associated with multiple foci in bilateral lobes and higher rates of capsular invasions than tumors in other thyroid regions. These findings indicate that total thyroidectomy is an appropriate initial surgical procedure for the isthmic PTC.",
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Lee, YS, Jeong, JJ, Nam, KH, Chung, WY, Chang, HS & Park, CS 2010, 'Papillary carcinoma located in the thyroid isthmus', World Journal of Surgery, vol. 34, no. 1, pp. 36-39. https://doi.org/10.1007/s00268-009-0298-6

Papillary carcinoma located in the thyroid isthmus. / Lee, Yong Sang; Jeong, Jong Ju; Nam, Kee Hyun; Chung, Woong Youn; Chang, Hang Seok; Park, Cheong Soo.

In: World Journal of Surgery, Vol. 34, No. 1, 01.01.2010, p. 36-39.

Research output: Contribution to journalArticle

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T1 - Papillary carcinoma located in the thyroid isthmus

AU - Lee, Yong Sang

AU - Jeong, Jong Ju

AU - Nam, Kee Hyun

AU - Chung, Woong Youn

AU - Chang, Hang Seok

AU - Park, Cheong Soo

PY - 2010/1/1

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N2 - Background: The purpose of the present study was to evaluate the clinicopathologic characteristics and short-term outcomes of papillary thyroid carcinomas (PTC) located in the isthmus compared to tumors located in other thyroid regions, and to use those findings to establish a surgical strategy for treating these tumors. Patients and methods: Thyroidectomy was performed in 1,973 thyroid cancer patients in our hospital between January 2006 and December 2007. The patients were analyzed in two groups; group I, patients with tumors located in the isthmus (n = 181) and group II, patients with tumors located in other thyroid regions (n = 1,792). The clinicopathologic characteristics and short-term outcomes were compared between the two groups. Results: The study groups were similar in terms of age and gender ratio. For groups I and II, respectively, the mean primary tumor size was 1.02 cm and 1.13 cm (p = 0.017), capsular invasion frequency was 70.2 and 60.8% (p = 0.008), and multifocality frequency was 48.6 and 39.8% (p = 0.006). In addition, central node involvement was 40.3 and 42.1% (p = 0.350), and lateral node involvement was 9.4 and 18.2% (p = 0.001). At the time of postoperative iodine-131 remnant ablation, 34.3% of group I patients and 38.0% of group II patients showed undetectable serum thyroglobulin concentrations. There were no significant differences in surgical complications between the two groups. Conclusions: Papillary thyroid carcinomas located in the isthmus was more likely to be associated with multiple foci in bilateral lobes and higher rates of capsular invasions than tumors in other thyroid regions. These findings indicate that total thyroidectomy is an appropriate initial surgical procedure for the isthmic PTC.

AB - Background: The purpose of the present study was to evaluate the clinicopathologic characteristics and short-term outcomes of papillary thyroid carcinomas (PTC) located in the isthmus compared to tumors located in other thyroid regions, and to use those findings to establish a surgical strategy for treating these tumors. Patients and methods: Thyroidectomy was performed in 1,973 thyroid cancer patients in our hospital between January 2006 and December 2007. The patients were analyzed in two groups; group I, patients with tumors located in the isthmus (n = 181) and group II, patients with tumors located in other thyroid regions (n = 1,792). The clinicopathologic characteristics and short-term outcomes were compared between the two groups. Results: The study groups were similar in terms of age and gender ratio. For groups I and II, respectively, the mean primary tumor size was 1.02 cm and 1.13 cm (p = 0.017), capsular invasion frequency was 70.2 and 60.8% (p = 0.008), and multifocality frequency was 48.6 and 39.8% (p = 0.006). In addition, central node involvement was 40.3 and 42.1% (p = 0.350), and lateral node involvement was 9.4 and 18.2% (p = 0.001). At the time of postoperative iodine-131 remnant ablation, 34.3% of group I patients and 38.0% of group II patients showed undetectable serum thyroglobulin concentrations. There were no significant differences in surgical complications between the two groups. Conclusions: Papillary thyroid carcinomas located in the isthmus was more likely to be associated with multiple foci in bilateral lobes and higher rates of capsular invasions than tumors in other thyroid regions. These findings indicate that total thyroidectomy is an appropriate initial surgical procedure for the isthmic PTC.

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