Papillary carcinoma of the thyroid gland with nodular fasciitis-like stroma

Ki Yong Na, Hyunsoo Kim, Ji Youn Sung, Won Seo Park, Youn Wha Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is a rare variant of PTC. The term 'PTC with fibromatosis-like stroma' has been used as a synonym to describe this variant. It is characterized by extensive proliferation of fibroblasts and myofibroblasts in the tumor stroma, which occurs in up to 80% of the tumors. We herein describe a case of PTC-NFS which developed in a 49-year-old woman with the demonstration of findings of ultrasonography, fine needle aspiration cytology and histological examination of the lesion. To characterize the stromal components, we investigated the expression of several immunohistochemical markers which have been shown to be expressed differently in nodular fasciitis (NF) and fibromatosis (FM). The immunostaining results demonstrated nuclear and cytoplasmic accumulation of β-catenin, cytoplasmic transforming growth factor-β expression and nuclear Smad expression in the stromal cells, suggesting that the stromal cells in this case have similar molecular profiles to those of FM rather than NF.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalKorean Journal of Pathology
Volume47
Issue number2
DOIs
Publication statusPublished - 2013 Jun 26

Fingerprint

Fasciitis
Fibroma
Thyroid Gland
Factor IX
Stromal Cells
Catenins
Myofibroblasts
Transforming Growth Factors
Fine Needle Biopsy
Cell Biology
Ultrasonography
Neoplasms
Fibroblasts
Papillary Thyroid cancer

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Na, Ki Yong ; Kim, Hyunsoo ; Sung, Ji Youn ; Park, Won Seo ; Kim, Youn Wha. / Papillary carcinoma of the thyroid gland with nodular fasciitis-like stroma. In: Korean Journal of Pathology. 2013 ; Vol. 47, No. 2. pp. 167-171.
@article{601a68c0dc344994a3d10fb233d64769,
title = "Papillary carcinoma of the thyroid gland with nodular fasciitis-like stroma",
abstract = "Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is a rare variant of PTC. The term 'PTC with fibromatosis-like stroma' has been used as a synonym to describe this variant. It is characterized by extensive proliferation of fibroblasts and myofibroblasts in the tumor stroma, which occurs in up to 80{\%} of the tumors. We herein describe a case of PTC-NFS which developed in a 49-year-old woman with the demonstration of findings of ultrasonography, fine needle aspiration cytology and histological examination of the lesion. To characterize the stromal components, we investigated the expression of several immunohistochemical markers which have been shown to be expressed differently in nodular fasciitis (NF) and fibromatosis (FM). The immunostaining results demonstrated nuclear and cytoplasmic accumulation of β-catenin, cytoplasmic transforming growth factor-β expression and nuclear Smad expression in the stromal cells, suggesting that the stromal cells in this case have similar molecular profiles to those of FM rather than NF.",
author = "Na, {Ki Yong} and Hyunsoo Kim and Sung, {Ji Youn} and Park, {Won Seo} and Kim, {Youn Wha}",
year = "2013",
month = "6",
day = "26",
doi = "10.4132/KoreanJPathol.2013.47.2.167",
language = "English",
volume = "47",
pages = "167--171",
journal = "Journal of Pathology and Translational Medicine",
issn = "2383-7837",
publisher = "Korean Society of Pathologists",
number = "2",

}

Papillary carcinoma of the thyroid gland with nodular fasciitis-like stroma. / Na, Ki Yong; Kim, Hyunsoo; Sung, Ji Youn; Park, Won Seo; Kim, Youn Wha.

In: Korean Journal of Pathology, Vol. 47, No. 2, 26.06.2013, p. 167-171.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Papillary carcinoma of the thyroid gland with nodular fasciitis-like stroma

AU - Na, Ki Yong

AU - Kim, Hyunsoo

AU - Sung, Ji Youn

AU - Park, Won Seo

AU - Kim, Youn Wha

PY - 2013/6/26

Y1 - 2013/6/26

N2 - Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is a rare variant of PTC. The term 'PTC with fibromatosis-like stroma' has been used as a synonym to describe this variant. It is characterized by extensive proliferation of fibroblasts and myofibroblasts in the tumor stroma, which occurs in up to 80% of the tumors. We herein describe a case of PTC-NFS which developed in a 49-year-old woman with the demonstration of findings of ultrasonography, fine needle aspiration cytology and histological examination of the lesion. To characterize the stromal components, we investigated the expression of several immunohistochemical markers which have been shown to be expressed differently in nodular fasciitis (NF) and fibromatosis (FM). The immunostaining results demonstrated nuclear and cytoplasmic accumulation of β-catenin, cytoplasmic transforming growth factor-β expression and nuclear Smad expression in the stromal cells, suggesting that the stromal cells in this case have similar molecular profiles to those of FM rather than NF.

AB - Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is a rare variant of PTC. The term 'PTC with fibromatosis-like stroma' has been used as a synonym to describe this variant. It is characterized by extensive proliferation of fibroblasts and myofibroblasts in the tumor stroma, which occurs in up to 80% of the tumors. We herein describe a case of PTC-NFS which developed in a 49-year-old woman with the demonstration of findings of ultrasonography, fine needle aspiration cytology and histological examination of the lesion. To characterize the stromal components, we investigated the expression of several immunohistochemical markers which have been shown to be expressed differently in nodular fasciitis (NF) and fibromatosis (FM). The immunostaining results demonstrated nuclear and cytoplasmic accumulation of β-catenin, cytoplasmic transforming growth factor-β expression and nuclear Smad expression in the stromal cells, suggesting that the stromal cells in this case have similar molecular profiles to those of FM rather than NF.

UR - http://www.scopus.com/inward/record.url?scp=84879238132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879238132&partnerID=8YFLogxK

U2 - 10.4132/KoreanJPathol.2013.47.2.167

DO - 10.4132/KoreanJPathol.2013.47.2.167

M3 - Article

C2 - 23667377

AN - SCOPUS:84879238132

VL - 47

SP - 167

EP - 171

JO - Journal of Pathology and Translational Medicine

JF - Journal of Pathology and Translational Medicine

SN - 2383-7837

IS - 2

ER -