Abstract
Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is a rare variant of PTC. The term 'PTC with fibromatosis-like stroma' has been used as a synonym to describe this variant. It is characterized by extensive proliferation of fibroblasts and myofibroblasts in the tumor stroma, which occurs in up to 80% of the tumors. We herein describe a case of PTC-NFS which developed in a 49-year-old woman with the demonstration of findings of ultrasonography, fine needle aspiration cytology and histological examination of the lesion. To characterize the stromal components, we investigated the expression of several immunohistochemical markers which have been shown to be expressed differently in nodular fasciitis (NF) and fibromatosis (FM). The immunostaining results demonstrated nuclear and cytoplasmic accumulation of β-catenin, cytoplasmic transforming growth factor-β expression and nuclear Smad expression in the stromal cells, suggesting that the stromal cells in this case have similar molecular profiles to those of FM rather than NF.
| Original language | English |
|---|---|
| Pages (from-to) | 167-171 |
| Number of pages | 5 |
| Journal | Korean Journal of Pathology |
| Volume | 47 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2013 Jun 26 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
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Papillary carcinoma of the thyroid gland with nodular fasciitis-like stroma. / Na, Ki Yong; Kim, Hyunsoo; Sung, Ji Youn; Park, Won Seo; Kim, Youn Wha.
In: Korean Journal of Pathology, Vol. 47, No. 2, 26.06.2013, p. 167-171.Research output: Contribution to journal › Article
TY - JOUR
T1 - Papillary carcinoma of the thyroid gland with nodular fasciitis-like stroma
AU - Na, Ki Yong
AU - Kim, Hyunsoo
AU - Sung, Ji Youn
AU - Park, Won Seo
AU - Kim, Youn Wha
PY - 2013/6/26
Y1 - 2013/6/26
N2 - Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is a rare variant of PTC. The term 'PTC with fibromatosis-like stroma' has been used as a synonym to describe this variant. It is characterized by extensive proliferation of fibroblasts and myofibroblasts in the tumor stroma, which occurs in up to 80% of the tumors. We herein describe a case of PTC-NFS which developed in a 49-year-old woman with the demonstration of findings of ultrasonography, fine needle aspiration cytology and histological examination of the lesion. To characterize the stromal components, we investigated the expression of several immunohistochemical markers which have been shown to be expressed differently in nodular fasciitis (NF) and fibromatosis (FM). The immunostaining results demonstrated nuclear and cytoplasmic accumulation of β-catenin, cytoplasmic transforming growth factor-β expression and nuclear Smad expression in the stromal cells, suggesting that the stromal cells in this case have similar molecular profiles to those of FM rather than NF.
AB - Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is a rare variant of PTC. The term 'PTC with fibromatosis-like stroma' has been used as a synonym to describe this variant. It is characterized by extensive proliferation of fibroblasts and myofibroblasts in the tumor stroma, which occurs in up to 80% of the tumors. We herein describe a case of PTC-NFS which developed in a 49-year-old woman with the demonstration of findings of ultrasonography, fine needle aspiration cytology and histological examination of the lesion. To characterize the stromal components, we investigated the expression of several immunohistochemical markers which have been shown to be expressed differently in nodular fasciitis (NF) and fibromatosis (FM). The immunostaining results demonstrated nuclear and cytoplasmic accumulation of β-catenin, cytoplasmic transforming growth factor-β expression and nuclear Smad expression in the stromal cells, suggesting that the stromal cells in this case have similar molecular profiles to those of FM rather than NF.
UR - http://www.scopus.com/inward/record.url?scp=84879238132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879238132&partnerID=8YFLogxK
U2 - 10.4132/KoreanJPathol.2013.47.2.167
DO - 10.4132/KoreanJPathol.2013.47.2.167
M3 - Article
C2 - 23667377
AN - SCOPUS:84879238132
VL - 47
SP - 167
EP - 171
JO - Journal of Pathology and Translational Medicine
JF - Journal of Pathology and Translational Medicine
SN - 2383-7837
IS - 2
ER -