Paraneoplastic pemphigus associated with a malignant thymoma: A case of persistent and refractory oral ulcerations following thymectomy

Jung Min Lim, Sang Eun Lee, Jimyung Seo, Do Young Kim, Takashi Hashimoto, Soo Chan Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Paraneoplastic pemphigus is a rare, life-threatening autoimmune mucocutaneous blistering disease associated with underlying neoplasia, commonly lymphoproliferative tumors. Herein we report a case of paraneoplastic pemphigus with a unique autoantibody profile associated with a malignant thymoma. A 56-year-old female patient presented with relapsing oral ulcerations accompanied by erythematous papules and patches on her extremities for 2 months. Skin and mucosal biopsies identified interface dermatitis with lichenoid lymphocytic infiltration in the upper dermis. Immunoblotting and enzyme-linked immunosorbent assays revealed that the patient had multiple autoantibodies against desmoglein 1, desmocollin 1, 2, 3, laminin gamma-1, envoplakin, and periplakin. The skin lesions completely healed following thymectomy and systemic corticosteroid therapy, but the oral ulcerations persisted through a follow-up period of over 2 years.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalAnnals of Dermatology
Volume29
Issue number2
DOIs
Publication statusPublished - 2017 Apr

All Science Journal Classification (ASJC) codes

  • Dermatology

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