Parathyroid carcinoma

A 16-year experience in a single institution

Yong Sang Lee, Soon Won Hong, Jong Ju Jeong, Kee Hyun Nam, Woong Youn Chung, Hang-Seok Chang, Cheong Soo Park

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Introduction: This study aims to describe our experiences of parathyroid carcinoma. Materials and Methods: The data of clinicopathological features, surgical treatment and outcomes of seven cases of parathyroid carcinoma among 171 patients who underwent surgery for primary hyperparathyroidism over a 16-year period were analyzed. Results: The major symptoms at the diagnosis included a neck mass in three cases and multiple bone pain in five. Two patients were asymptomatic. No remarkable increases of serum calcium levels were noted in the patients, but serum parathyroid hormone (PTH) concentrations were high in most of the patients (4 of 5 in available). A variety of imaging studies including ultrasonography, sestamibi scan, and computed tomography scan were helpful in identifying the abnormal parathyroid glands, but not specific for the diagnosis of parathyroid carcinoma. In most patients, the parathyroid carcinomas were suspected at the time of neck exploration, and confirmed by final histopathologic examinations. All patients underwent complete surgical excision with curative intent. During the follow-up period, one patient developed lung metastases 6 years later and the other one died of unrelated cause. Conclusion: Preoperative diagnosis of parathyroid carcinoma is difficult, but operative findings are helpful in the diagnosis. The optimal surgical treatment is en block radical resection including adjacent structures when parathyroid carcinoma is suspected. Unusually, although our patients presented with high serum PTH concentrations, they had normal or mild elevated serum calcium concentrations. The reason of why should be investigated in future studies.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalEndocrine Journal
Volume57
Issue number6
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Parathyroid Neoplasms
Parathyroid Hormone
Serum
Neck
Calcium
Parathyroid Glands
Primary Hyperparathyroidism
Ultrasonography
Tomography
Neoplasm Metastasis
Bone and Bones
Pain
Lung

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lee, Y. S., Hong, S. W., Jeong, J. J., Nam, K. H., Chung, W. Y., Chang, H-S., & Park, C. S. (2010). Parathyroid carcinoma: A 16-year experience in a single institution. Endocrine Journal, 57(6), 493-497. https://doi.org/10.1507/endocrj.K09E-365
Lee, Yong Sang ; Hong, Soon Won ; Jeong, Jong Ju ; Nam, Kee Hyun ; Chung, Woong Youn ; Chang, Hang-Seok ; Park, Cheong Soo. / Parathyroid carcinoma : A 16-year experience in a single institution. In: Endocrine Journal. 2010 ; Vol. 57, No. 6. pp. 493-497.
@article{76c741294cbd4817ab2ebec48f128188,
title = "Parathyroid carcinoma: A 16-year experience in a single institution",
abstract = "Introduction: This study aims to describe our experiences of parathyroid carcinoma. Materials and Methods: The data of clinicopathological features, surgical treatment and outcomes of seven cases of parathyroid carcinoma among 171 patients who underwent surgery for primary hyperparathyroidism over a 16-year period were analyzed. Results: The major symptoms at the diagnosis included a neck mass in three cases and multiple bone pain in five. Two patients were asymptomatic. No remarkable increases of serum calcium levels were noted in the patients, but serum parathyroid hormone (PTH) concentrations were high in most of the patients (4 of 5 in available). A variety of imaging studies including ultrasonography, sestamibi scan, and computed tomography scan were helpful in identifying the abnormal parathyroid glands, but not specific for the diagnosis of parathyroid carcinoma. In most patients, the parathyroid carcinomas were suspected at the time of neck exploration, and confirmed by final histopathologic examinations. All patients underwent complete surgical excision with curative intent. During the follow-up period, one patient developed lung metastases 6 years later and the other one died of unrelated cause. Conclusion: Preoperative diagnosis of parathyroid carcinoma is difficult, but operative findings are helpful in the diagnosis. The optimal surgical treatment is en block radical resection including adjacent structures when parathyroid carcinoma is suspected. Unusually, although our patients presented with high serum PTH concentrations, they had normal or mild elevated serum calcium concentrations. The reason of why should be investigated in future studies.",
author = "Lee, {Yong Sang} and Hong, {Soon Won} and Jeong, {Jong Ju} and Nam, {Kee Hyun} and Chung, {Woong Youn} and Hang-Seok Chang and Park, {Cheong Soo}",
year = "2010",
month = "1",
day = "1",
doi = "10.1507/endocrj.K09E-365",
language = "English",
volume = "57",
pages = "493--497",
journal = "Endocrine Journal",
issn = "0918-8959",
publisher = "Japan Endocrine Society",
number = "6",

}

Lee, YS, Hong, SW, Jeong, JJ, Nam, KH, Chung, WY, Chang, H-S & Park, CS 2010, 'Parathyroid carcinoma: A 16-year experience in a single institution', Endocrine Journal, vol. 57, no. 6, pp. 493-497. https://doi.org/10.1507/endocrj.K09E-365

Parathyroid carcinoma : A 16-year experience in a single institution. / Lee, Yong Sang; Hong, Soon Won; Jeong, Jong Ju; Nam, Kee Hyun; Chung, Woong Youn; Chang, Hang-Seok; Park, Cheong Soo.

In: Endocrine Journal, Vol. 57, No. 6, 01.01.2010, p. 493-497.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Parathyroid carcinoma

T2 - A 16-year experience in a single institution

AU - Lee, Yong Sang

AU - Hong, Soon Won

AU - Jeong, Jong Ju

AU - Nam, Kee Hyun

AU - Chung, Woong Youn

AU - Chang, Hang-Seok

AU - Park, Cheong Soo

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Introduction: This study aims to describe our experiences of parathyroid carcinoma. Materials and Methods: The data of clinicopathological features, surgical treatment and outcomes of seven cases of parathyroid carcinoma among 171 patients who underwent surgery for primary hyperparathyroidism over a 16-year period were analyzed. Results: The major symptoms at the diagnosis included a neck mass in three cases and multiple bone pain in five. Two patients were asymptomatic. No remarkable increases of serum calcium levels were noted in the patients, but serum parathyroid hormone (PTH) concentrations were high in most of the patients (4 of 5 in available). A variety of imaging studies including ultrasonography, sestamibi scan, and computed tomography scan were helpful in identifying the abnormal parathyroid glands, but not specific for the diagnosis of parathyroid carcinoma. In most patients, the parathyroid carcinomas were suspected at the time of neck exploration, and confirmed by final histopathologic examinations. All patients underwent complete surgical excision with curative intent. During the follow-up period, one patient developed lung metastases 6 years later and the other one died of unrelated cause. Conclusion: Preoperative diagnosis of parathyroid carcinoma is difficult, but operative findings are helpful in the diagnosis. The optimal surgical treatment is en block radical resection including adjacent structures when parathyroid carcinoma is suspected. Unusually, although our patients presented with high serum PTH concentrations, they had normal or mild elevated serum calcium concentrations. The reason of why should be investigated in future studies.

AB - Introduction: This study aims to describe our experiences of parathyroid carcinoma. Materials and Methods: The data of clinicopathological features, surgical treatment and outcomes of seven cases of parathyroid carcinoma among 171 patients who underwent surgery for primary hyperparathyroidism over a 16-year period were analyzed. Results: The major symptoms at the diagnosis included a neck mass in three cases and multiple bone pain in five. Two patients were asymptomatic. No remarkable increases of serum calcium levels were noted in the patients, but serum parathyroid hormone (PTH) concentrations were high in most of the patients (4 of 5 in available). A variety of imaging studies including ultrasonography, sestamibi scan, and computed tomography scan were helpful in identifying the abnormal parathyroid glands, but not specific for the diagnosis of parathyroid carcinoma. In most patients, the parathyroid carcinomas were suspected at the time of neck exploration, and confirmed by final histopathologic examinations. All patients underwent complete surgical excision with curative intent. During the follow-up period, one patient developed lung metastases 6 years later and the other one died of unrelated cause. Conclusion: Preoperative diagnosis of parathyroid carcinoma is difficult, but operative findings are helpful in the diagnosis. The optimal surgical treatment is en block radical resection including adjacent structures when parathyroid carcinoma is suspected. Unusually, although our patients presented with high serum PTH concentrations, they had normal or mild elevated serum calcium concentrations. The reason of why should be investigated in future studies.

UR - http://www.scopus.com/inward/record.url?scp=77954753268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954753268&partnerID=8YFLogxK

U2 - 10.1507/endocrj.K09E-365

DO - 10.1507/endocrj.K09E-365

M3 - Article

VL - 57

SP - 493

EP - 497

JO - Endocrine Journal

JF - Endocrine Journal

SN - 0918-8959

IS - 6

ER -