Parathyroid Hormone, Calcium, and Sodium Bridging Between Osteoporosis and Hypertension in Postmenopausal Korean Women

Jee Soo Park, Soo Beom Choi, Yumie Rhee, Jai Won Chung, Eui Young Choi, Deok Won Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The coexistence of osteoporosis and hypertension, which are considered distinct diseases, has been widely reported. In addition, daily intake of calcium and sodium, as well as parathyroid hormone levels (PTH), is known to be associated with osteoporosis and hypertension. This study aimed to determine the association of low calcium intake, high sodium intake, and PTH levels with osteoporosis and hypertension in postmenopausal Korean women. Data for postmenopausal Korean women aged 50 years or older were obtained from the Korea National Health and Nutrition Examination Survey 2008–2011. Osteoporosis was diagnosed using dual energy X-ray absorptiometry, while hypertension was diagnosed using blood pressure data. The odds ratios for osteoporosis and hypertension were calculated using logistic regression analysis for quartiles of the daily calcium intake, daily sodium intake, and PTH levels. Women with hypertension had a high coexistence of osteoporosis (43.6 vs. 36.5 %; P = 0.022), and vice versa (21.1 vs. 16.6 %; P = 0.022). PTH was significantly associated with osteoporosis and hypertension, and a high intake of calcium was strongly correlated with a low incidence of osteoporosis. This is the first study to report the characteristics of postmenopausal Korean women who have high dietary sodium intake and low dietary calcium intake, in association with the incidence of osteoporosis and hypertension. Osteoporosis and hypertension were strongly associated with each other, and PTH appears to be a key mediator of both diseases, suggesting a possible pathogenic link.

Original languageEnglish
Pages (from-to)417-429
Number of pages13
JournalCalcified Tissue International
Volume96
Issue number5
DOIs
Publication statusPublished - 2015 May 1

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Parathyroid Hormone
Osteoporosis
Sodium
Hypertension
Calcium
Dietary Sodium
Dietary Calcium
Nutrition Surveys
Incidence
Photon Absorptiometry
Korea
Logistic Models
Odds Ratio
Regression Analysis
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Park, Jee Soo ; Choi, Soo Beom ; Rhee, Yumie ; Chung, Jai Won ; Choi, Eui Young ; Kim, Deok Won. / Parathyroid Hormone, Calcium, and Sodium Bridging Between Osteoporosis and Hypertension in Postmenopausal Korean Women. In: Calcified Tissue International. 2015 ; Vol. 96, No. 5. pp. 417-429.
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Parathyroid Hormone, Calcium, and Sodium Bridging Between Osteoporosis and Hypertension in Postmenopausal Korean Women. / Park, Jee Soo; Choi, Soo Beom; Rhee, Yumie; Chung, Jai Won; Choi, Eui Young; Kim, Deok Won.

In: Calcified Tissue International, Vol. 96, No. 5, 01.05.2015, p. 417-429.

Research output: Contribution to journalArticle

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