Parkinsonian Patients with Striatal Cribriform State Present Rapidly Progressive Axial Parkinsonism

Seung Ha Lee, Chul Hyoung Lyoo, Hanna Cho, Juha O. Rinne, Myung Sik Lee

Research output: Contribution to journalArticle

Abstract

Objective: To define the significance of striatal cribriform state (SCS) observed in patients with primary progressive parkinsonism. Methods: We reviewed medical records and brain magnetic resonance imaging studies of 1,260 patients with primary progressive parkinsonism. We identified 23 patients with SCS and analyzed their clinical features. Results: All 23 patients had rapidly progressive parkinsonism predominated by postural instability and gait disturbance. Clinical features of 18 of the 23 patients were compatible with progressive supranuclear palsy (PSP); 2 patients were compatible with parkinsonian type multiple system atrophy; 2 patients were compatible with mixed clinical features of both; and 1 patient had PSP-like clinical features. Conclusions: Most parkinsonian patients with SCS present rapidly progressive parkinsonism predominated by postural instability and gait disturbance. SCS observed in patients with parkinsonism does not seem to be a coincidental finding associated with the generalized cerebrovascular process.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalEuropean Neurology
Volume78
Issue number3-4
DOIs
Publication statusPublished - 2017 Sep 1

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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