The aim of the present study was to screen the effects of the formulation variables - POLYOX® molecular weight (X1), the ratio of POLYOX®/Avicel® PH102 (X2) and the amount of POLYOX® and Avicel® PH102 (X3), hardness (X4), HPMCP amount (X5), Eudragit® L100 amount (X6), and citric acid amount (X7) - on the paroxetine hydrochloride release from POLYOX® matrix tablet using the Plackett-Burman screening design. Paroxetine hydrochloride matrix tablets were prepared according to a 7-factor-12-run statistical model and subjected to a 8-h dissolution study in Tris buffer at pH 7.5. The regression results showed that POLYOX® molecular weight (X 1) and POLYOX®/Avicel® PH102 ratio (X2) had significantly influence on the drug release mechanism and drug release rate as main effects. Hardness (X4) had an insignificant effect on the drug release mechanism but a significant effect on the drug release rate. On the other hand, HPMCP, Eudragit® L100 and citric acid had an insignificant effect on the both responses. The information obtained by screening design study can be expected to be useful for further formulation studies.
Bibliographical noteFunding Information:
This study was financially supported by research fund of Chungnam National University in 2007.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery
- Organic Chemistry