Partial conduction block as an early nerve conduction finding in neurolymphomatosis

Hyung Jun Park, Ha Young Shin, SeHoon Kim, Ha Neul Jeong, Youngchul Choi, Bum Chun Suh, Kee Duk Park, Seung Min Kim

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Abstract

Background and Purpose Neurolymphomatosis is a rare manifestation of hematological malignancy and is characterized by direct infiltration of the peripheral nervous system. The objective of this study was to identify the clinical and electrophysiological features of neurolymphomatosis. Methods We retrospectively analyzed the medical records of 13 patients with neurolymphomatosis. Seven (54%) of the patients were men, and the median age at symptom onset was 60.0 years. Results The most common type of underlying malignancy was diffuse large B-cell lymphoma (69%). Twelve patients had painful asymmetric neuropathies. The median survival time after diagnosis was 7 months, and 12 patients died during the study period. Thirty-eight motor nerve conduction studies (NCSs) were performed in the affected nerves. Ten and 28 motor nerves were classified into the conduction-block and simple-axon-degeneration groups, respectively. The median time interval between symptom onset and the NCS was significantly shorter in the conduction-block group than in the simple-axon-degeneration group (p=0.032). However, no significant differences in the motor nerve conduction velocities, terminal laten-cies, and distal compound muscle action potential amplitudes were identified between the conduction-block and simple-axon-degeneration groups. The conduction-block group showed excessive temporal dispersion in only five of the ten NCSs (50%). Follow-up NCSs revealed that partial conduction blocks had changed into axonal degeneration patterns. Conclusions This is the first study to analyze the electrophysiological features of patients with neurolymphomatosis. Our findings showed that a partial conduction block is not rare and is an early nerve conduction abnormality in neurolymphomatosis.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalJournal of Clinical Neurology (Korea)
Volume14
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Marek Disease
Neural Conduction
Axons
Lymphoma, Large B-Cell, Diffuse
Peripheral Nervous System
Hematologic Neoplasms
Age of Onset
Action Potentials
Medical Records
Muscles
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Park, Hyung Jun ; Shin, Ha Young ; Kim, SeHoon ; Jeong, Ha Neul ; Choi, Youngchul ; Suh, Bum Chun ; Park, Kee Duk ; Kim, Seung Min. / Partial conduction block as an early nerve conduction finding in neurolymphomatosis. In: Journal of Clinical Neurology (Korea). 2018 ; Vol. 14, No. 1. pp. 73-80.
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abstract = "Background and Purpose Neurolymphomatosis is a rare manifestation of hematological malignancy and is characterized by direct infiltration of the peripheral nervous system. The objective of this study was to identify the clinical and electrophysiological features of neurolymphomatosis. Methods We retrospectively analyzed the medical records of 13 patients with neurolymphomatosis. Seven (54{\%}) of the patients were men, and the median age at symptom onset was 60.0 years. Results The most common type of underlying malignancy was diffuse large B-cell lymphoma (69{\%}). Twelve patients had painful asymmetric neuropathies. The median survival time after diagnosis was 7 months, and 12 patients died during the study period. Thirty-eight motor nerve conduction studies (NCSs) were performed in the affected nerves. Ten and 28 motor nerves were classified into the conduction-block and simple-axon-degeneration groups, respectively. The median time interval between symptom onset and the NCS was significantly shorter in the conduction-block group than in the simple-axon-degeneration group (p=0.032). However, no significant differences in the motor nerve conduction velocities, terminal laten-cies, and distal compound muscle action potential amplitudes were identified between the conduction-block and simple-axon-degeneration groups. The conduction-block group showed excessive temporal dispersion in only five of the ten NCSs (50{\%}). Follow-up NCSs revealed that partial conduction blocks had changed into axonal degeneration patterns. Conclusions This is the first study to analyze the electrophysiological features of patients with neurolymphomatosis. Our findings showed that a partial conduction block is not rare and is an early nerve conduction abnormality in neurolymphomatosis.",
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Partial conduction block as an early nerve conduction finding in neurolymphomatosis. / Park, Hyung Jun; Shin, Ha Young; Kim, SeHoon; Jeong, Ha Neul; Choi, Youngchul; Suh, Bum Chun; Park, Kee Duk; Kim, Seung Min.

In: Journal of Clinical Neurology (Korea), Vol. 14, No. 1, 01.01.2018, p. 73-80.

Research output: Contribution to journalArticle

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N2 - Background and Purpose Neurolymphomatosis is a rare manifestation of hematological malignancy and is characterized by direct infiltration of the peripheral nervous system. The objective of this study was to identify the clinical and electrophysiological features of neurolymphomatosis. Methods We retrospectively analyzed the medical records of 13 patients with neurolymphomatosis. Seven (54%) of the patients were men, and the median age at symptom onset was 60.0 years. Results The most common type of underlying malignancy was diffuse large B-cell lymphoma (69%). Twelve patients had painful asymmetric neuropathies. The median survival time after diagnosis was 7 months, and 12 patients died during the study period. Thirty-eight motor nerve conduction studies (NCSs) were performed in the affected nerves. Ten and 28 motor nerves were classified into the conduction-block and simple-axon-degeneration groups, respectively. The median time interval between symptom onset and the NCS was significantly shorter in the conduction-block group than in the simple-axon-degeneration group (p=0.032). However, no significant differences in the motor nerve conduction velocities, terminal laten-cies, and distal compound muscle action potential amplitudes were identified between the conduction-block and simple-axon-degeneration groups. The conduction-block group showed excessive temporal dispersion in only five of the ten NCSs (50%). Follow-up NCSs revealed that partial conduction blocks had changed into axonal degeneration patterns. Conclusions This is the first study to analyze the electrophysiological features of patients with neurolymphomatosis. Our findings showed that a partial conduction block is not rare and is an early nerve conduction abnormality in neurolymphomatosis.

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