Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography

Youn Sang Bae; Chang Ha Lee

doi:10.1016/j.chroma.2006.04.040

Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography

Youn Sang Bae, Chang Ha Lee

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

A new "partial-discard" operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. This strategy was applied to the four-zone SMB process with two columns per zone for binary separation within the linear range. The "partial-discard" strategy significantly enhanced the purity or enrichment when the discard time and discard length were controlled. In addition, the "partial-feed with partial-discard" strategy improved remarkably the extract and raffinate purities at an intermediate feed time compared with the "partial-feed" operation. Adjustments of the discard length and discard time played key roles in achieving the desired product purity in SMB chromatographic performance.

Original language	English
Pages (from-to)	161-173
Number of pages	13
Journal	Journal of Chromatography A
Volume	1122
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2006.04.040
Publication status	Published - 2006 Jul 28

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2005-042-D00070).

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Organic Chemistry

Access to Document

10.1016/j.chroma.2006.04.040

Fingerprint Dive into the research topics of 'Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography'. Together they form a unique fingerprint.

Cite this

@article{0598ec0d124f46b48f6006924fe2cf8c,

title = "Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography",

abstract = "A new {"}partial-discard{"} operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. This strategy was applied to the four-zone SMB process with two columns per zone for binary separation within the linear range. The {"}partial-discard{"} strategy significantly enhanced the purity or enrichment when the discard time and discard length were controlled. In addition, the {"}partial-feed with partial-discard{"} strategy improved remarkably the extract and raffinate purities at an intermediate feed time compared with the {"}partial-feed{"} operation. Adjustments of the discard length and discard time played key roles in achieving the desired product purity in SMB chromatographic performance.",

author = "Bae, {Youn Sang} and Lee, {Chang Ha}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2005-042-D00070).",

year = "2006",

month = jul,

day = "28",

doi = "10.1016/j.chroma.2006.04.040",

language = "English",

volume = "1122",

pages = "161--173",

journal = "Journal of Chromatography A",

issn = "0021-9673",

number = "1-2",

}

TY - JOUR

T1 - Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography

AU - Bae, Youn Sang

AU - Lee, Chang Ha

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2005-042-D00070).

PY - 2006/7/28

Y1 - 2006/7/28

N2 - A new "partial-discard" operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. This strategy was applied to the four-zone SMB process with two columns per zone for binary separation within the linear range. The "partial-discard" strategy significantly enhanced the purity or enrichment when the discard time and discard length were controlled. In addition, the "partial-feed with partial-discard" strategy improved remarkably the extract and raffinate purities at an intermediate feed time compared with the "partial-feed" operation. Adjustments of the discard length and discard time played key roles in achieving the desired product purity in SMB chromatographic performance.

AB - A new "partial-discard" operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. This strategy was applied to the four-zone SMB process with two columns per zone for binary separation within the linear range. The "partial-discard" strategy significantly enhanced the purity or enrichment when the discard time and discard length were controlled. In addition, the "partial-feed with partial-discard" strategy improved remarkably the extract and raffinate purities at an intermediate feed time compared with the "partial-feed" operation. Adjustments of the discard length and discard time played key roles in achieving the desired product purity in SMB chromatographic performance.

UR - http://www.scopus.com/inward/record.url?scp=33745879481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745879481&partnerID=8YFLogxK

U2 - 10.1016/j.chroma.2006.04.040

DO - 10.1016/j.chroma.2006.04.040

M3 - Article

C2 - 16690063

AN - SCOPUS:33745879481

VL - 1122

SP - 161

EP - 173

JO - Journal of Chromatography A

JF - Journal of Chromatography A

SN - 0021-9673

IS - 1-2

ER -

Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Cite this