Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography

Youn Sang Bae; Chang Ha Lee

doi:10.1016/j.chroma.2006.04.040

Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography

Youn Sang Bae, Chang Ha Lee

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

A new "partial-discard" operation strategy was developed to improve the performance, especially purity, achievable in simulated moving bed (SMB) chromatography. This strategy was applied to the four-zone SMB process with two columns per zone for binary separation within the linear range. The "partial-discard" strategy significantly enhanced the purity or enrichment when the discard time and discard length were controlled. In addition, the "partial-feed with partial-discard" strategy improved remarkably the extract and raffinate purities at an intermediate feed time compared with the "partial-feed" operation. Adjustments of the discard length and discard time played key roles in achieving the desired product purity in SMB chromatographic performance.

Original language	English
Pages (from-to)	161-173
Number of pages	13
Journal	Journal of Chromatography A
Volume	1122
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2006.04.040
Publication status	Published - 2006 Jul 28

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2005-042-D00070).

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Organic Chemistry

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