Pathogenesis of minimal change nephrotic syndrome

An immunological concept

Seong Heon Kim, Se Jin Park, Kyoung Hee Han, Andreas Kronbichler, Moin A. Saleem, Jun Oh, Beom Jin Lim, Jaeil Shin

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia. Minimal change nephrotic syndrome (MCNS) is the most common form of INS in children. The pathogenesis of MCNS still remains unclear, however, several hypotheses have been recently proposed. For several decades, MCNS has been considered a T-cell disorder, which causes the impairment of the glomerular filtration barrier with the release of different circulating factors. Increased levels of several cytokines are also suggested. Recently, a “two-hit” theory was proposed that included the induction of CD80 (B7-1) and regulatory T-cell (Treg) dysfunction, with or without impaired autoregulatory functions of the podocyte. In contrast to the well-established involvement of T cells, the role of B cells has not been clearly identified. However, B-cell biology has recently gained more attention, because rituximab (a monoclonal antibody directed against CD20-bearing cells) demonstrated a very good therapeutic response in the treatment of childhood and adult MCNS. Here, we discuss recent insights into the pathogenesis of MCNS in children.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalKorean Journal of Pediatrics
Volume59
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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Lipoid Nephrosis
B-Lymphocytes
Glomerular Filtration Barrier
T-Lymphocytes
Podocytes
Hypoalbuminemia
Regulatory T-Lymphocytes
Proteinuria
Cell Biology
Monoclonal Antibodies
Cytokines
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

Kim, Seong Heon ; Park, Se Jin ; Han, Kyoung Hee ; Kronbichler, Andreas ; Saleem, Moin A. ; Oh, Jun ; Lim, Beom Jin ; Shin, Jaeil. / Pathogenesis of minimal change nephrotic syndrome : An immunological concept. In: Korean Journal of Pediatrics. 2016 ; Vol. 59, No. 5. pp. 205-211.
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abstract = "Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia. Minimal change nephrotic syndrome (MCNS) is the most common form of INS in children. The pathogenesis of MCNS still remains unclear, however, several hypotheses have been recently proposed. For several decades, MCNS has been considered a T-cell disorder, which causes the impairment of the glomerular filtration barrier with the release of different circulating factors. Increased levels of several cytokines are also suggested. Recently, a “two-hit” theory was proposed that included the induction of CD80 (B7-1) and regulatory T-cell (Treg) dysfunction, with or without impaired autoregulatory functions of the podocyte. In contrast to the well-established involvement of T cells, the role of B cells has not been clearly identified. However, B-cell biology has recently gained more attention, because rituximab (a monoclonal antibody directed against CD20-bearing cells) demonstrated a very good therapeutic response in the treatment of childhood and adult MCNS. Here, we discuss recent insights into the pathogenesis of MCNS in children.",
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Kim, SH, Park, SJ, Han, KH, Kronbichler, A, Saleem, MA, Oh, J, Lim, BJ & Shin, J 2016, 'Pathogenesis of minimal change nephrotic syndrome: An immunological concept', Korean Journal of Pediatrics, vol. 59, no. 5, pp. 205-211. https://doi.org/10.3345/kjp.2016.59.5.205

Pathogenesis of minimal change nephrotic syndrome : An immunological concept. / Kim, Seong Heon; Park, Se Jin; Han, Kyoung Hee; Kronbichler, Andreas; Saleem, Moin A.; Oh, Jun; Lim, Beom Jin; Shin, Jaeil.

In: Korean Journal of Pediatrics, Vol. 59, No. 5, 01.05.2016, p. 205-211.

Research output: Contribution to journalReview article

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AU - Kim, Seong Heon

AU - Park, Se Jin

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AU - Kronbichler, Andreas

AU - Saleem, Moin A.

AU - Oh, Jun

AU - Lim, Beom Jin

AU - Shin, Jaeil

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