TY - JOUR
T1 - Pathogenomic signaling networks and antifungal drug development for human fungal pathogen Cryptococcus neoformans
AU - Ko, Young Joon
AU - Kwon, Yoo Won
AU - Na, Hanna
AU - Bahn, Yong Sun
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/3
Y1 - 2010/3
N2 - Past decade systemic mycoses caused by opportunistic human fungal pathogens, including Candida, Aspergillus, and Cryptococcus, have been a growing problem for both immunocompromised and immunocompetent individuals. Particularly, Cryptococcus neoformans has recently emerged as a major fungal pathogen, which can cause fungal pneumonia and meningitis that are lethal if not timely medicated. However, treatment for cryptococcosis has been difficult due to a lack of proper anti-cryptococcal drugs with fungicidal activity and less toxicity. In this review we introduced novel therapeutic methods for treating cryptococcosis by exploring pathogenomic signaling networks of C. neoformans with genome-wide transcriptome approaches as well as diverse molecular/genetic tools.
AB - Past decade systemic mycoses caused by opportunistic human fungal pathogens, including Candida, Aspergillus, and Cryptococcus, have been a growing problem for both immunocompromised and immunocompetent individuals. Particularly, Cryptococcus neoformans has recently emerged as a major fungal pathogen, which can cause fungal pneumonia and meningitis that are lethal if not timely medicated. However, treatment for cryptococcosis has been difficult due to a lack of proper anti-cryptococcal drugs with fungicidal activity and less toxicity. In this review we introduced novel therapeutic methods for treating cryptococcosis by exploring pathogenomic signaling networks of C. neoformans with genome-wide transcriptome approaches as well as diverse molecular/genetic tools.
UR - http://www.scopus.com/inward/record.url?scp=77950968130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950968130&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:77950968130
VL - 38
SP - 13
EP - 18
JO - Microbiology and Biotechnology Letters
JF - Microbiology and Biotechnology Letters
SN - 1598-642X
IS - 1
ER -