Pathogenomic signaling networks and antifungal drug development for human fungal pathogen Cryptococcus neoformans

Young Joon Ko, Yoo Won Kwon, Hanna Na, Yong Sun Bahn

Research output: Contribution to journalReview article

Abstract

Past decade systemic mycoses caused by opportunistic human fungal pathogens, including Candida, Aspergillus, and Cryptococcus, have been a growing problem for both immunocompromised and immunocompetent individuals. Particularly, Cryptococcus neoformans has recently emerged as a major fungal pathogen, which can cause fungal pneumonia and meningitis that are lethal if not timely medicated. However, treatment for cryptococcosis has been difficult due to a lack of proper anti-cryptococcal drugs with fungicidal activity and less toxicity. In this review we introduced novel therapeutic methods for treating cryptococcosis by exploring pathogenomic signaling networks of C. neoformans with genome-wide transcriptome approaches as well as diverse molecular/genetic tools.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalKorean Journal of Microbiology and Biotechnology
Volume38
Issue number1
Publication statusPublished - 2010 Mar 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Microbiology
  • Applied Microbiology and Biotechnology

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