Abstract
Aims: The aim of this study was to identify the characteristics of PDGFRA-mutated gastrointestinal stromal tumours GISTs in comparison with KIT-mutated GISTs. Methods: A total of 151 GISTs were examined for KIT and PDGFRA mutations, and clinical and histopathological parameters were evaluated and analysed statistically according to mutation status. Results: KIT and PDGFRA mutations were detected in 123 81.5 and 15 cases 9.9, respectively. Clinically, all PDGFRA-mutated GISTs were located in the stomach with no recurrences and tumour-related deaths were noted. Pathological parameters associated with PDGFRA mutations were epithelioid and mixed type, low to moderate cellularity, moderate to severe intratumoural lymphocytic infiltration, prominent myxoid change, frequent rhabdoid cells and multinucleated giant cells, increased cellular pleomorphism, low mitotic count, and lower risk assessment p < 0.05. Compared with KIT-mutated GISTs, PDGFRA-mutated GISTs had unique histopathological patterns, intermingling of spindle and epithelioid cells, andor a jigsaw puzzle-like arrangement of epithelioid cells. Conclusions: PDGFRA-mutated GISTs have distinctive histological patterns that are differentiated from KIT-mutated GISTs. The algorithmic approach by a combination of several distinguishing histological and immunohistochemical features between KIT- and PDGFRA-mutated GISTs might be helpful in predicting the mutated gene of each GIST on pathological examination.
| Original language | English |
|---|---|
| Pages (from-to) | 544-554 |
| Number of pages | 11 |
| Journal | Pathology |
| Volume | 41 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2009 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
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Pathological characteristics of gastrointestinal stromal tumours with PDGFRA mutations. / Kwon, Ji Eun; Kang, Hyun Ju; Kim, SeHoon; Lee, Yongchan; Hyung, WooJin; Noh, Sung Hoon; Kim, Namkyu; Kim, Hoguen.
In: Pathology, Vol. 41, No. 6, 01.01.2009, p. 544-554.Research output: Contribution to journal › Article
TY - JOUR
T1 - Pathological characteristics of gastrointestinal stromal tumours with PDGFRA mutations
AU - Kwon, Ji Eun
AU - Kang, Hyun Ju
AU - Kim, SeHoon
AU - Lee, Yongchan
AU - Hyung, WooJin
AU - Noh, Sung Hoon
AU - Kim, Namkyu
AU - Kim, Hoguen
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Aims: The aim of this study was to identify the characteristics of PDGFRA-mutated gastrointestinal stromal tumours GISTs in comparison with KIT-mutated GISTs. Methods: A total of 151 GISTs were examined for KIT and PDGFRA mutations, and clinical and histopathological parameters were evaluated and analysed statistically according to mutation status. Results: KIT and PDGFRA mutations were detected in 123 81.5 and 15 cases 9.9, respectively. Clinically, all PDGFRA-mutated GISTs were located in the stomach with no recurrences and tumour-related deaths were noted. Pathological parameters associated with PDGFRA mutations were epithelioid and mixed type, low to moderate cellularity, moderate to severe intratumoural lymphocytic infiltration, prominent myxoid change, frequent rhabdoid cells and multinucleated giant cells, increased cellular pleomorphism, low mitotic count, and lower risk assessment p < 0.05. Compared with KIT-mutated GISTs, PDGFRA-mutated GISTs had unique histopathological patterns, intermingling of spindle and epithelioid cells, andor a jigsaw puzzle-like arrangement of epithelioid cells. Conclusions: PDGFRA-mutated GISTs have distinctive histological patterns that are differentiated from KIT-mutated GISTs. The algorithmic approach by a combination of several distinguishing histological and immunohistochemical features between KIT- and PDGFRA-mutated GISTs might be helpful in predicting the mutated gene of each GIST on pathological examination.
AB - Aims: The aim of this study was to identify the characteristics of PDGFRA-mutated gastrointestinal stromal tumours GISTs in comparison with KIT-mutated GISTs. Methods: A total of 151 GISTs were examined for KIT and PDGFRA mutations, and clinical and histopathological parameters were evaluated and analysed statistically according to mutation status. Results: KIT and PDGFRA mutations were detected in 123 81.5 and 15 cases 9.9, respectively. Clinically, all PDGFRA-mutated GISTs were located in the stomach with no recurrences and tumour-related deaths were noted. Pathological parameters associated with PDGFRA mutations were epithelioid and mixed type, low to moderate cellularity, moderate to severe intratumoural lymphocytic infiltration, prominent myxoid change, frequent rhabdoid cells and multinucleated giant cells, increased cellular pleomorphism, low mitotic count, and lower risk assessment p < 0.05. Compared with KIT-mutated GISTs, PDGFRA-mutated GISTs had unique histopathological patterns, intermingling of spindle and epithelioid cells, andor a jigsaw puzzle-like arrangement of epithelioid cells. Conclusions: PDGFRA-mutated GISTs have distinctive histological patterns that are differentiated from KIT-mutated GISTs. The algorithmic approach by a combination of several distinguishing histological and immunohistochemical features between KIT- and PDGFRA-mutated GISTs might be helpful in predicting the mutated gene of each GIST on pathological examination.
UR - http://www.scopus.com/inward/record.url?scp=70350638559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350638559&partnerID=8YFLogxK
U2 - 10.1080/00313020903071421
DO - 10.1080/00313020903071421
M3 - Article
C2 - 19900103
AN - SCOPUS:70350638559
VL - 41
SP - 544
EP - 554
JO - Pathology
JF - Pathology
SN - 0031-3025
IS - 6
ER -