Pathological characteristics of prostate cancer in men aged < 50 years treated with radical prostatectomy

A multi-centre study in Korea

Mun Su Chung, Myungsun Shim, Jin Seon Cho, Woojin Bang, Sun Il Kim, Sung Yong Cho, KoonHo Rha, Sung Joon Hong, Kyo Chul Koo, Kwang Suk Lee, Byungha Chung, Seung Hwan Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Recently, younger prostate cancer (PCa) patients have been reported to harbour more favourable disease characteristics after radical prostatectomy (RP) than older men. We analysed young men (<50 years) with PCa among the Korean population, paying attention to pathological characteristics on RP specimen and biochemical recurrence (BCR). Methods: The multi-centre, Severance Urological Oncology Group registry was utilized to identify 622 patients with clinically localized or locally advanced PCa, who were treated with RP between 2001 and 2017. Patients were dichotomized into two groups according to age (< 50-year-old [n = 75] and = 50-year-old [n = 547]), and clinicopathological characteristics were analysed. Propensity score matching was used when assessing BCR between the two groups. Results: Although biopsy Gleason score (GS) was lower in younger patients (P = 0.033), distribution of pathologic GS was similar between the two groups (13.3% vs. 13.9% for GS = 8, P = 0.191). There was no significant difference in pathologic T stage between the < 50- and = 50-year-old groups (69.3% vs. 68.0% in T2 and 30.7% vs. 32.0% in = T3, P = 0.203). The positive surgical margin rates were similar between the two groups (20.0% vs. 27.6%, P = 0.178). BCR-free survival rates were also similar (P = 0.644) between the two groups, after propensity matching. Conclusion: Contrary to prior reports, younger PCa patients did not have more favourable pathologic features on RP specimen and showed similar BCR rates compared to older men. These findings should be considered when making treatment decisions for young Korean patients with PCa.

Original languageEnglish
Article numbere78
JournalJournal of Korean medical science
Volume34
Issue number10
DOIs
Publication statusPublished - 2019 Mar 18

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Korea
Prostatectomy
Prostatic Neoplasms
Neoplasm Grading
Recurrence
Propensity Score
Registries
Decision Making
Survival Rate
Biopsy
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chung, Mun Su ; Shim, Myungsun ; Cho, Jin Seon ; Bang, Woojin ; Kim, Sun Il ; Cho, Sung Yong ; Rha, KoonHo ; Hong, Sung Joon ; Koo, Kyo Chul ; Lee, Kwang Suk ; Chung, Byungha ; Lee, Seung Hwan. / Pathological characteristics of prostate cancer in men aged < 50 years treated with radical prostatectomy : A multi-centre study in Korea. In: Journal of Korean medical science. 2019 ; Vol. 34, No. 10.
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title = "Pathological characteristics of prostate cancer in men aged < 50 years treated with radical prostatectomy: A multi-centre study in Korea",
abstract = "Background: Recently, younger prostate cancer (PCa) patients have been reported to harbour more favourable disease characteristics after radical prostatectomy (RP) than older men. We analysed young men (<50 years) with PCa among the Korean population, paying attention to pathological characteristics on RP specimen and biochemical recurrence (BCR). Methods: The multi-centre, Severance Urological Oncology Group registry was utilized to identify 622 patients with clinically localized or locally advanced PCa, who were treated with RP between 2001 and 2017. Patients were dichotomized into two groups according to age (< 50-year-old [n = 75] and = 50-year-old [n = 547]), and clinicopathological characteristics were analysed. Propensity score matching was used when assessing BCR between the two groups. Results: Although biopsy Gleason score (GS) was lower in younger patients (P = 0.033), distribution of pathologic GS was similar between the two groups (13.3{\%} vs. 13.9{\%} for GS = 8, P = 0.191). There was no significant difference in pathologic T stage between the < 50- and = 50-year-old groups (69.3{\%} vs. 68.0{\%} in T2 and 30.7{\%} vs. 32.0{\%} in = T3, P = 0.203). The positive surgical margin rates were similar between the two groups (20.0{\%} vs. 27.6{\%}, P = 0.178). BCR-free survival rates were also similar (P = 0.644) between the two groups, after propensity matching. Conclusion: Contrary to prior reports, younger PCa patients did not have more favourable pathologic features on RP specimen and showed similar BCR rates compared to older men. These findings should be considered when making treatment decisions for young Korean patients with PCa.",
author = "Chung, {Mun Su} and Myungsun Shim and Cho, {Jin Seon} and Woojin Bang and Kim, {Sun Il} and Cho, {Sung Yong} and KoonHo Rha and Hong, {Sung Joon} and Koo, {Kyo Chul} and Lee, {Kwang Suk} and Byungha Chung and Lee, {Seung Hwan}",
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Pathological characteristics of prostate cancer in men aged < 50 years treated with radical prostatectomy : A multi-centre study in Korea. / Chung, Mun Su; Shim, Myungsun; Cho, Jin Seon; Bang, Woojin; Kim, Sun Il; Cho, Sung Yong; Rha, KoonHo; Hong, Sung Joon; Koo, Kyo Chul; Lee, Kwang Suk; Chung, Byungha; Lee, Seung Hwan.

In: Journal of Korean medical science, Vol. 34, No. 10, e78, 18.03.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pathological characteristics of prostate cancer in men aged < 50 years treated with radical prostatectomy

T2 - A multi-centre study in Korea

AU - Chung, Mun Su

AU - Shim, Myungsun

AU - Cho, Jin Seon

AU - Bang, Woojin

AU - Kim, Sun Il

AU - Cho, Sung Yong

AU - Rha, KoonHo

AU - Hong, Sung Joon

AU - Koo, Kyo Chul

AU - Lee, Kwang Suk

AU - Chung, Byungha

AU - Lee, Seung Hwan

PY - 2019/3/18

Y1 - 2019/3/18

N2 - Background: Recently, younger prostate cancer (PCa) patients have been reported to harbour more favourable disease characteristics after radical prostatectomy (RP) than older men. We analysed young men (<50 years) with PCa among the Korean population, paying attention to pathological characteristics on RP specimen and biochemical recurrence (BCR). Methods: The multi-centre, Severance Urological Oncology Group registry was utilized to identify 622 patients with clinically localized or locally advanced PCa, who were treated with RP between 2001 and 2017. Patients were dichotomized into two groups according to age (< 50-year-old [n = 75] and = 50-year-old [n = 547]), and clinicopathological characteristics were analysed. Propensity score matching was used when assessing BCR between the two groups. Results: Although biopsy Gleason score (GS) was lower in younger patients (P = 0.033), distribution of pathologic GS was similar between the two groups (13.3% vs. 13.9% for GS = 8, P = 0.191). There was no significant difference in pathologic T stage between the < 50- and = 50-year-old groups (69.3% vs. 68.0% in T2 and 30.7% vs. 32.0% in = T3, P = 0.203). The positive surgical margin rates were similar between the two groups (20.0% vs. 27.6%, P = 0.178). BCR-free survival rates were also similar (P = 0.644) between the two groups, after propensity matching. Conclusion: Contrary to prior reports, younger PCa patients did not have more favourable pathologic features on RP specimen and showed similar BCR rates compared to older men. These findings should be considered when making treatment decisions for young Korean patients with PCa.

AB - Background: Recently, younger prostate cancer (PCa) patients have been reported to harbour more favourable disease characteristics after radical prostatectomy (RP) than older men. We analysed young men (<50 years) with PCa among the Korean population, paying attention to pathological characteristics on RP specimen and biochemical recurrence (BCR). Methods: The multi-centre, Severance Urological Oncology Group registry was utilized to identify 622 patients with clinically localized or locally advanced PCa, who were treated with RP between 2001 and 2017. Patients were dichotomized into two groups according to age (< 50-year-old [n = 75] and = 50-year-old [n = 547]), and clinicopathological characteristics were analysed. Propensity score matching was used when assessing BCR between the two groups. Results: Although biopsy Gleason score (GS) was lower in younger patients (P = 0.033), distribution of pathologic GS was similar between the two groups (13.3% vs. 13.9% for GS = 8, P = 0.191). There was no significant difference in pathologic T stage between the < 50- and = 50-year-old groups (69.3% vs. 68.0% in T2 and 30.7% vs. 32.0% in = T3, P = 0.203). The positive surgical margin rates were similar between the two groups (20.0% vs. 27.6%, P = 0.178). BCR-free survival rates were also similar (P = 0.644) between the two groups, after propensity matching. Conclusion: Contrary to prior reports, younger PCa patients did not have more favourable pathologic features on RP specimen and showed similar BCR rates compared to older men. These findings should be considered when making treatment decisions for young Korean patients with PCa.

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U2 - 10.3346/jkms.2019.34.e78

DO - 10.3346/jkms.2019.34.e78

M3 - Article

VL - 34

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

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