Pathophysiologic and therapeutic perspectives based on thrombus histology in stroke

Ji Hoe Heo, Hyo Suk Nam, Young Dae Kim, Jin Kyo Choi, Byung Moon Kim, Dong Joon Kim, Il Kwon

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Recent advances in endovascular thrombectomy have enabled the histopathologic analysis of fresh thrombi in patients with acute stroke. Histologic analysis has shown that the thrombus composition is very heterogeneous between patients. However, the distribution pattern of each thrombus component often differs between patients with cardiac thrombi and those with arterial thrombi, and the efficacy of endovascular thrombectomy is different according to the thrombus composition. Furthermore, the thrombus age is related to the efficacy of reperfusion therapy. Recent studies have shown that neutrophils and neutrophil extracellular traps contribute to thrombus formation and resistance to reperfusion therapy. Histologic features of thrombi in patients with stroke may provide some clues to stroke etiology, which is helpful for determining the strategy of stroke prevention. Research on thrombus may also be helpful for improving reperfusion therapy, including the development of new thrombolytic agents.

Original languageEnglish
Pages (from-to)64-75
Number of pages12
JournalJournal of Stroke
Volume22
Issue number1
DOIs
Publication statusPublished - 2020 Jan

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A2A3074996), and by a faculty research grant of Yonsei University College of Medicine (6-2018-0185). The authors thank Medical Illustration & Design, part of the Medical Research Support Services of Yonsei University College of Medicine, for all artistic support related to this work.

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A2A3074996), and by a faculty research grant of Yonsei University College of Medicine (6-2018-0185).

Publisher Copyright:
© 2020 Korean Stroke Society.

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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