Pathophysiologic Characteristics and Clinical Outcomes of Catheter Ablation in Patients with Atrial Fibrillation Associated with Diabetes

Sook Kyoung Kim, Boyoung Joung, Moon Hyoung Lee, huinam pak

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Abstract

Background The left atrial (LA) remodeling is related to the clinical outcome and the risk of stroke in patients with atrial fibrillation (AF) who underwent radiofrequency Catheter ablation (RFCA). We hypothesized that the LA remodeling and clinical outcome of RFCA are different in patients with AF associated with diabetes (DM), which is a risk factor for stroke. Methods and Results We included 530 patients with AF who underwent RFCA, and compared imaging parameters and pro-ANP and TGF-? plasma between patients with DM (n=54) and without DM (n=476). 1. DM group was older (p<0.0001) and had higher CHADS2 scores (p<0.0001), higher proportions of previous stroke (p=0.0134) or hypertension (p<0.0001) than non-DM group. 2. DM group had greater LA diameter (p=0.0396) with higher E/E, (p=0.0045), LA pressure (p=0.0200), and pro-ANP (p=0.0096), but lower TGF-? (p=0.0043) than non-DM group. 3. Although peri-procedural complication rates (1.85% vs. 1.68%, p=0.4641) and recurrence rates (18.37% vs. 16.75%, p=0.3874) were similar between two groups, the early recurrence rate was rather lower (22.45% vs. 35.61%, p=0.0331) in DM group than in non-DM group. Conclusion: Despite more advanced LA remodeling related to diastolic dysfunction and atrial hemodynamic overload in patients with AF and DM, the peri-procedural complication and clinical recurrence rates were comparable to patients without DM after RFCA.

Original languageEnglish
Number of pages1
Journaljournal of arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1

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Catheter Ablation
Atrial Fibrillation
Atrial Remodeling
Stroke
Atrial Natriuretic Factor
Recurrence
Atrial Pressure
Hemodynamics
Hypertension

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{b1287f11ae384cf4b7f681ce4ba7b7cd,
title = "Pathophysiologic Characteristics and Clinical Outcomes of Catheter Ablation in Patients with Atrial Fibrillation Associated with Diabetes",
abstract = "Background The left atrial (LA) remodeling is related to the clinical outcome and the risk of stroke in patients with atrial fibrillation (AF) who underwent radiofrequency Catheter ablation (RFCA). We hypothesized that the LA remodeling and clinical outcome of RFCA are different in patients with AF associated with diabetes (DM), which is a risk factor for stroke. Methods and Results We included 530 patients with AF who underwent RFCA, and compared imaging parameters and pro-ANP and TGF-? plasma between patients with DM (n=54) and without DM (n=476). 1. DM group was older (p<0.0001) and had higher CHADS2 scores (p<0.0001), higher proportions of previous stroke (p=0.0134) or hypertension (p<0.0001) than non-DM group. 2. DM group had greater LA diameter (p=0.0396) with higher E/E, (p=0.0045), LA pressure (p=0.0200), and pro-ANP (p=0.0096), but lower TGF-? (p=0.0043) than non-DM group. 3. Although peri-procedural complication rates (1.85{\%} vs. 1.68{\%}, p=0.4641) and recurrence rates (18.37{\%} vs. 16.75{\%}, p=0.3874) were similar between two groups, the early recurrence rate was rather lower (22.45{\%} vs. 35.61{\%}, p=0.0331) in DM group than in non-DM group. Conclusion: Despite more advanced LA remodeling related to diastolic dysfunction and atrial hemodynamic overload in patients with AF and DM, the peri-procedural complication and clinical recurrence rates were comparable to patients without DM after RFCA.",
author = "Kim, {Sook Kyoung} and Boyoung Joung and Lee, {Moon Hyoung} and huinam pak",
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T1 - Pathophysiologic Characteristics and Clinical Outcomes of Catheter Ablation in Patients with Atrial Fibrillation Associated with Diabetes

AU - Kim, Sook Kyoung

AU - Joung, Boyoung

AU - Lee, Moon Hyoung

AU - pak, huinam

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background The left atrial (LA) remodeling is related to the clinical outcome and the risk of stroke in patients with atrial fibrillation (AF) who underwent radiofrequency Catheter ablation (RFCA). We hypothesized that the LA remodeling and clinical outcome of RFCA are different in patients with AF associated with diabetes (DM), which is a risk factor for stroke. Methods and Results We included 530 patients with AF who underwent RFCA, and compared imaging parameters and pro-ANP and TGF-? plasma between patients with DM (n=54) and without DM (n=476). 1. DM group was older (p<0.0001) and had higher CHADS2 scores (p<0.0001), higher proportions of previous stroke (p=0.0134) or hypertension (p<0.0001) than non-DM group. 2. DM group had greater LA diameter (p=0.0396) with higher E/E, (p=0.0045), LA pressure (p=0.0200), and pro-ANP (p=0.0096), but lower TGF-? (p=0.0043) than non-DM group. 3. Although peri-procedural complication rates (1.85% vs. 1.68%, p=0.4641) and recurrence rates (18.37% vs. 16.75%, p=0.3874) were similar between two groups, the early recurrence rate was rather lower (22.45% vs. 35.61%, p=0.0331) in DM group than in non-DM group. Conclusion: Despite more advanced LA remodeling related to diastolic dysfunction and atrial hemodynamic overload in patients with AF and DM, the peri-procedural complication and clinical recurrence rates were comparable to patients without DM after RFCA.

AB - Background The left atrial (LA) remodeling is related to the clinical outcome and the risk of stroke in patients with atrial fibrillation (AF) who underwent radiofrequency Catheter ablation (RFCA). We hypothesized that the LA remodeling and clinical outcome of RFCA are different in patients with AF associated with diabetes (DM), which is a risk factor for stroke. Methods and Results We included 530 patients with AF who underwent RFCA, and compared imaging parameters and pro-ANP and TGF-? plasma between patients with DM (n=54) and without DM (n=476). 1. DM group was older (p<0.0001) and had higher CHADS2 scores (p<0.0001), higher proportions of previous stroke (p=0.0134) or hypertension (p<0.0001) than non-DM group. 2. DM group had greater LA diameter (p=0.0396) with higher E/E, (p=0.0045), LA pressure (p=0.0200), and pro-ANP (p=0.0096), but lower TGF-? (p=0.0043) than non-DM group. 3. Although peri-procedural complication rates (1.85% vs. 1.68%, p=0.4641) and recurrence rates (18.37% vs. 16.75%, p=0.3874) were similar between two groups, the early recurrence rate was rather lower (22.45% vs. 35.61%, p=0.0331) in DM group than in non-DM group. Conclusion: Despite more advanced LA remodeling related to diastolic dysfunction and atrial hemodynamic overload in patients with AF and DM, the peri-procedural complication and clinical recurrence rates were comparable to patients without DM after RFCA.

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