[Pathophysiology of portal hypertension, what's new?].

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Portal hypertension (PHT) is associated with changes in the intrahepatic, systemic and portosystemic collateral circulations. Alteration in vasoreactivity (vasodilation and vasoconstriction) plays a central role in the pathogenesis of PHT by contributing to increased intrahepatic resistance, hyperdynamic circulation and the expansion of the collateral circulation. PHT is also importantly characterized by changes in vascular structure; termed vascular remodeling, which is an adaptive response of the vessel wall that occurs in response to chronic changes in the environment such as shear stress. Angiogenesis, the sprouting of new blood vessels, also occurs in PHT, especially in the expansion of the portosystemic collateral circulation. These complementary processes of vasoreactivity, vascular remodeling and angiogenesis represent important targets in the research for the treatment of portal hypertension.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume56
Issue number3
DOIs
Publication statusPublished - 2010 Sep

Fingerprint

Portal Hypertension
Collateral Circulation
Blood Vessels
Vasoconstriction
Vasodilation
Research
Vascular Remodeling

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Portal hypertension (PHT) is associated with changes in the intrahepatic, systemic and portosystemic collateral circulations. Alteration in vasoreactivity (vasodilation and vasoconstriction) plays a central role in the pathogenesis of PHT by contributing to increased intrahepatic resistance, hyperdynamic circulation and the expansion of the collateral circulation. PHT is also importantly characterized by changes in vascular structure; termed vascular remodeling, which is an adaptive response of the vessel wall that occurs in response to chronic changes in the environment such as shear stress. Angiogenesis, the sprouting of new blood vessels, also occurs in PHT, especially in the expansion of the portosystemic collateral circulation. These complementary processes of vasoreactivity, vascular remodeling and angiogenesis represent important targets in the research for the treatment of portal hypertension.",
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[Pathophysiology of portal hypertension, what's new?]. / Kim, Moon Young; Baik, Soon Koo.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 56, No. 3, 09.2010, p. 129-134.

Research output: Contribution to journalReview article

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