Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer

Sang Wook Kang; Zeng Z. Yap; Cho Rok Lee; Jandee Lee; Jong Ju Jeong; Kee Hyun Nam; Mi Jin Yun; Eun Jig Lee; Woong Youn Chung; Cheong Soo Park

doi:10.1002/hed.25441

Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer

Sang Wook Kang, Zeng Z. Yap, Cho Rok Lee, Jandee Lee, Jong Ju Jeong, Kee Hyun Nam, Mi Jin Yun, Eun Jig Lee, Woong Youn Chung, Cheong Soo Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background: The optimal period of low iodine diet during preparation for radioactive iodine (RAI) ablation in an area with iodine-rich diet was investigated. Methods: Ninety-four patients with thyroid cancer who underwent low iodine diet and RAI were prospectively allocated into 2 groups—thyroxine withdrawal or using recombinant human thyroid stimulating hormone (rhTSH) for TSH stimulation. Their urinary iodine excretion (UIE) patterns were analyzed. Results: There was no clinicopathological difference between the 2 groups except for tumor size and lymph node status. The UIE (median iodine to creatinine ratio, I/Cr) in the withdrawal group on the 7th and 14th day were 18.3 and 17.9 μg/gCr, respectively, with adequate preparation rate of 93.3% on both days (cutoff value 100 μg/gCr). In the rhTSH group, the median I/Cr on the 7th and 14th day were 48.0 and 45.7 μg/gCr (adequate preparation rates 91.8% and 93.8%), respectively. Conclusion: One week of low iodine diet is sufficient preparation for RAI regardless of method of TSH stimulation.

Original language	English
Pages (from-to)	381-387
Number of pages	7
Journal	Head and Neck
Volume	41
Issue number	2
DOIs	https://doi.org/10.1002/hed.25441
Publication status	Published - 2019 Feb

Bibliographical note

Funding Information:
The authors hereby attest that the study was funded by Sanofi-Genzyme Co. and disclose financial relations with Sanofi-Genzyme Co. The study, however, is not modified by the entity nor reflects particular interests. The authors whose names are listed in this study certify that they have no affiliations or involvement with Sanofi-Genzyme and declare no conflicts of interests with the entity.

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.25441

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@article{73de6ef787f1405baaa141da31e7966c,

title = "Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer",

abstract = "Background: The optimal period of low iodine diet during preparation for radioactive iodine (RAI) ablation in an area with iodine-rich diet was investigated. Methods: Ninety-four patients with thyroid cancer who underwent low iodine diet and RAI were prospectively allocated into 2 groups—thyroxine withdrawal or using recombinant human thyroid stimulating hormone (rhTSH) for TSH stimulation. Their urinary iodine excretion (UIE) patterns were analyzed. Results: There was no clinicopathological difference between the 2 groups except for tumor size and lymph node status. The UIE (median iodine to creatinine ratio, I/Cr) in the withdrawal group on the 7th and 14th day were 18.3 and 17.9 μg/gCr, respectively, with adequate preparation rate of 93.3% on both days (cutoff value 100 μg/gCr). In the rhTSH group, the median I/Cr on the 7th and 14th day were 48.0 and 45.7 μg/gCr (adequate preparation rates 91.8% and 93.8%), respectively. Conclusion: One week of low iodine diet is sufficient preparation for RAI regardless of method of TSH stimulation.",

author = "Kang, {Sang Wook} and Yap, {Zeng Z.} and Lee, {Cho Rok} and Jandee Lee and Jeong, {Jong Ju} and Nam, {Kee Hyun} and Yun, {Mi Jin} and Lee, {Eun Jig} and Chung, {Woong Youn} and Park, {Cheong Soo}",

note = "Funding Information: The authors hereby attest that the study was funded by Sanofi-Genzyme Co. and disclose financial relations with Sanofi-Genzyme Co. The study, however, is not modified by the entity nor reflects particular interests. The authors whose names are listed in this study certify that they have no affiliations or involvement with Sanofi-Genzyme and declare no conflicts of interests with the entity. Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2019",

month = feb,

doi = "10.1002/hed.25441",

language = "English",

volume = "41",

pages = "381--387",

journal = "Head and Neck Surgery",

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T1 - Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer

AU - Kang, Sang Wook

AU - Yap, Zeng Z.

AU - Lee, Cho Rok

AU - Lee, Jandee

AU - Jeong, Jong Ju

AU - Nam, Kee Hyun

AU - Yun, Mi Jin

AU - Lee, Eun Jig

AU - Chung, Woong Youn

AU - Park, Cheong Soo

N1 - Funding Information: The authors hereby attest that the study was funded by Sanofi-Genzyme Co. and disclose financial relations with Sanofi-Genzyme Co. The study, however, is not modified by the entity nor reflects particular interests. The authors whose names are listed in this study certify that they have no affiliations or involvement with Sanofi-Genzyme and declare no conflicts of interests with the entity. Publisher Copyright: © 2018 Wiley Periodicals, Inc.

PY - 2019/2

Y1 - 2019/2

N2 - Background: The optimal period of low iodine diet during preparation for radioactive iodine (RAI) ablation in an area with iodine-rich diet was investigated. Methods: Ninety-four patients with thyroid cancer who underwent low iodine diet and RAI were prospectively allocated into 2 groups—thyroxine withdrawal or using recombinant human thyroid stimulating hormone (rhTSH) for TSH stimulation. Their urinary iodine excretion (UIE) patterns were analyzed. Results: There was no clinicopathological difference between the 2 groups except for tumor size and lymph node status. The UIE (median iodine to creatinine ratio, I/Cr) in the withdrawal group on the 7th and 14th day were 18.3 and 17.9 μg/gCr, respectively, with adequate preparation rate of 93.3% on both days (cutoff value 100 μg/gCr). In the rhTSH group, the median I/Cr on the 7th and 14th day were 48.0 and 45.7 μg/gCr (adequate preparation rates 91.8% and 93.8%), respectively. Conclusion: One week of low iodine diet is sufficient preparation for RAI regardless of method of TSH stimulation.

AB - Background: The optimal period of low iodine diet during preparation for radioactive iodine (RAI) ablation in an area with iodine-rich diet was investigated. Methods: Ninety-four patients with thyroid cancer who underwent low iodine diet and RAI were prospectively allocated into 2 groups—thyroxine withdrawal or using recombinant human thyroid stimulating hormone (rhTSH) for TSH stimulation. Their urinary iodine excretion (UIE) patterns were analyzed. Results: There was no clinicopathological difference between the 2 groups except for tumor size and lymph node status. The UIE (median iodine to creatinine ratio, I/Cr) in the withdrawal group on the 7th and 14th day were 18.3 and 17.9 μg/gCr, respectively, with adequate preparation rate of 93.3% on both days (cutoff value 100 μg/gCr). In the rhTSH group, the median I/Cr on the 7th and 14th day were 48.0 and 45.7 μg/gCr (adequate preparation rates 91.8% and 93.8%), respectively. Conclusion: One week of low iodine diet is sufficient preparation for RAI regardless of method of TSH stimulation.

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Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer

Abstract

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