Background: The optimal period of low iodine diet during preparation for radioactive iodine (RAI) ablation in an area with iodine-rich diet was investigated. Methods: Ninety-four patients with thyroid cancer who underwent low iodine diet and RAI were prospectively allocated into 2 groups—thyroxine withdrawal or using recombinant human thyroid stimulating hormone (rhTSH) for TSH stimulation. Their urinary iodine excretion (UIE) patterns were analyzed. Results: There was no clinicopathological difference between the 2 groups except for tumor size and lymph node status. The UIE (median iodine to creatinine ratio, I/Cr) in the withdrawal group on the 7th and 14th day were 18.3 and 17.9 μg/gCr, respectively, with adequate preparation rate of 93.3% on both days (cutoff value 100 μg/gCr). In the rhTSH group, the median I/Cr on the 7th and 14th day were 48.0 and 45.7 μg/gCr (adequate preparation rates 91.8% and 93.8%), respectively. Conclusion: One week of low iodine diet is sufficient preparation for RAI regardless of method of TSH stimulation.
Bibliographical noteFunding Information:
The authors hereby attest that the study was funded by Sanofi-Genzyme Co. and disclose financial relations with Sanofi-Genzyme Co. The study, however, is not modified by the entity nor reflects particular interests. The authors whose names are listed in this study certify that they have no affiliations or involvement with Sanofi-Genzyme and declare no conflicts of interests with the entity.
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