Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer

Sang Wook Kang, Zeng Z. Yap, Cho Rok Lee, Jandee Lee, Jong Ju Jeong, Kee Hyun Nam, Mi Jin Yun, Eunjig Lee, Woong Youn Chung, Cheong Soo Park

Research output: Contribution to journalArticle

Abstract

Background: The optimal period of low iodine diet during preparation for radioactive iodine (RAI) ablation in an area with iodine-rich diet was investigated. Methods: Ninety-four patients with thyroid cancer who underwent low iodine diet and RAI were prospectively allocated into 2 groups—thyroxine withdrawal or using recombinant human thyroid stimulating hormone (rhTSH) for TSH stimulation. Their urinary iodine excretion (UIE) patterns were analyzed. Results: There was no clinicopathological difference between the 2 groups except for tumor size and lymph node status. The UIE (median iodine to creatinine ratio, I/Cr) in the withdrawal group on the 7th and 14th day were 18.3 and 17.9 μg/gCr, respectively, with adequate preparation rate of 93.3% on both days (cutoff value 100 μg/gCr). In the rhTSH group, the median I/Cr on the 7th and 14th day were 48.0 and 45.7 μg/gCr (adequate preparation rates 91.8% and 93.8%), respectively. Conclusion: One week of low iodine diet is sufficient preparation for RAI regardless of method of TSH stimulation.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalHead and Neck
Volume41
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1

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Thyroid Neoplasms
Iodine
Urine
Diet
Thyrotropin
Creatinine
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Kang, Sang Wook ; Yap, Zeng Z. ; Lee, Cho Rok ; Lee, Jandee ; Jeong, Jong Ju ; Nam, Kee Hyun ; Yun, Mi Jin ; Lee, Eunjig ; Chung, Woong Youn ; Park, Cheong Soo. / Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer. In: Head and Neck. 2019 ; Vol. 41, No. 2. pp. 381-387.
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Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer. / Kang, Sang Wook; Yap, Zeng Z.; Lee, Cho Rok; Lee, Jandee; Jeong, Jong Ju; Nam, Kee Hyun; Yun, Mi Jin; Lee, Eunjig; Chung, Woong Youn; Park, Cheong Soo.

In: Head and Neck, Vol. 41, No. 2, 01.02.2019, p. 381-387.

Research output: Contribution to journalArticle

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AU - Yap, Zeng Z.

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AU - Nam, Kee Hyun

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AU - Park, Cheong Soo

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N2 - Background: The optimal period of low iodine diet during preparation for radioactive iodine (RAI) ablation in an area with iodine-rich diet was investigated. Methods: Ninety-four patients with thyroid cancer who underwent low iodine diet and RAI were prospectively allocated into 2 groups—thyroxine withdrawal or using recombinant human thyroid stimulating hormone (rhTSH) for TSH stimulation. Their urinary iodine excretion (UIE) patterns were analyzed. Results: There was no clinicopathological difference between the 2 groups except for tumor size and lymph node status. The UIE (median iodine to creatinine ratio, I/Cr) in the withdrawal group on the 7th and 14th day were 18.3 and 17.9 μg/gCr, respectively, with adequate preparation rate of 93.3% on both days (cutoff value 100 μg/gCr). In the rhTSH group, the median I/Cr on the 7th and 14th day were 48.0 and 45.7 μg/gCr (adequate preparation rates 91.8% and 93.8%), respectively. Conclusion: One week of low iodine diet is sufficient preparation for RAI regardless of method of TSH stimulation.

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