Pattern-recognition receptor signaling initiated from extracellular, membrane and cytoplastic space

Myeong Sup Lee, Young-Joon Kim

Research output: Contribution to journalShort survey

69 Citations (Scopus)

Abstract

Invading pathogens are recognized by diverse germline-encoded pattern-recognition receptors (PRRs) which are distributed in three different cellular compartments: extracellular, membrane, and cytoplasmic. In mammals, the major extracellular PRRs such as complements may first encounter the invading pathogens and opsonize them for clearance by phagocytosis which is mediated by membrane-associated phagocytic receptors including complement receptors. The major membrane-associated PRRs, Toll-like receptors, recognize diverse pathogens and generate inflammatory signals to coordinate innate immune responses and shape adaptive immune responses. Furthemore, certain membrane-associated PRRs such as Dectin-1 can mediate phagocytosis and also induce inflammatory response. When these more forefront detection systems are avoided by the pathogens, cytoplasmic PRRs may play major roles. Cytoplasmic caspase-recruiting domain (CARD) helicases such as retinoic acid-inducible protein I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5), mediate antiviral immunity by inducing the production of type I interferons. Certain members of nucleotide-binding oligomerization domain (NOD)-like receptors such as NALP3 present in the cytosol form inflammasomes to induce inflammatory responses upon ligand recognition. Thus, diverse families of PRRs coordinately mediate immune responses against diverse types of pathogens.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalMolecules and cells
Volume23
Issue number1
Publication statusPublished - 2007 Feb 1

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Pattern Recognition Receptors
Membranes
Phagocytosis
Inflammasomes
Complement Receptors
Interferon Type I
Toll-Like Receptors
Adaptive Immunity
Caspases
Tretinoin
Innate Immunity
Cytosol
Antiviral Agents
Mammals
Immunity
Melanoma
Nucleotides
Cell Membrane
Ligands
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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Pattern-recognition receptor signaling initiated from extracellular, membrane and cytoplastic space. / Lee, Myeong Sup; Kim, Young-Joon.

In: Molecules and cells, Vol. 23, No. 1, 01.02.2007, p. 1-10.

Research output: Contribution to journalShort survey

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