Patterns of care for orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in Korea throughout 2016: Results from a multicenter cross-sectional cohort study (KROG 16–19)

Jeongshim Lee, Dongryul Oh, Byung Ock Choi, Keun Yong Eom, Jong Hoon Lee, Jung Hoon Kim, Sang Wook Lee, Yang Kwon Suh, Chang Ok Suh

Research output: Contribution to journalArticle

Abstract

Aim: Primary orbital mucosa-associated lymphoid tissue (MALT) lymphomas are generally sensitive to radiotherapy (RT), but a “wait and see” strategy has also been used in asymptomatic patients. Recently, orbital MALT lymphoma has been reported to be associated with Chlamydia psittaci infection. This study aimed to assess the current patterns of care in clinical practice for orbital MALT lymphoma in South Korea. Methods: We performed a multicenter, cross-sectional cohort study of patterns of care for orbital MALT lymphoma in South Korea throughout 2016. All patients were pathologically confirmed to have orbital MALT lymphoma. Results: Overall, eight institutions with 90 patients participated. The survey showed that the most frequent upfront treatment for orbital MALT lymphoma was RT (80/90, 90%). Other treatment modalities were given to a limited number of orbital MALT lymphoma patients as follows: watch and wait, 6/90 (7%); antibiotics, 3/90 (3%) and chemotherapy, 1/90 (1%). Generally, RT was administered to the entire involved site such as the entire conjunctiva/eyelid or entire orbit (96%), with a median total dose of 25.2 Gy. Lens shielding was performed for most patients with conjunctival and eyelid tumors (93%). Conclusions: RT was the conventional treatment modality for orbital MALT lymphoma. Currently, RT is performed for the entire involved subsites at a lower dose than that previously used, and lens shielding was applied to minimize the orbital complication.

Original languageEnglish
JournalAsia-Pacific Journal of Clinical Oncology
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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Marginal Zone B-Cell Lymphoma
Korea
Cohort Studies
Cross-Sectional Studies
Radiotherapy
Republic of Korea
Eyelids
Lenses
Chlamydophila psittaci
Chlamydia Infections
Conjunctiva
Orbit
Therapeutics
Anti-Bacterial Agents
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

@article{8e9c9e1302af40cd9b45544253a6242e,
title = "Patterns of care for orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in Korea throughout 2016: Results from a multicenter cross-sectional cohort study (KROG 16–19)",
abstract = "Aim: Primary orbital mucosa-associated lymphoid tissue (MALT) lymphomas are generally sensitive to radiotherapy (RT), but a “wait and see” strategy has also been used in asymptomatic patients. Recently, orbital MALT lymphoma has been reported to be associated with Chlamydia psittaci infection. This study aimed to assess the current patterns of care in clinical practice for orbital MALT lymphoma in South Korea. Methods: We performed a multicenter, cross-sectional cohort study of patterns of care for orbital MALT lymphoma in South Korea throughout 2016. All patients were pathologically confirmed to have orbital MALT lymphoma. Results: Overall, eight institutions with 90 patients participated. The survey showed that the most frequent upfront treatment for orbital MALT lymphoma was RT (80/90, 90{\%}). Other treatment modalities were given to a limited number of orbital MALT lymphoma patients as follows: watch and wait, 6/90 (7{\%}); antibiotics, 3/90 (3{\%}) and chemotherapy, 1/90 (1{\%}). Generally, RT was administered to the entire involved site such as the entire conjunctiva/eyelid or entire orbit (96{\%}), with a median total dose of 25.2 Gy. Lens shielding was performed for most patients with conjunctival and eyelid tumors (93{\%}). Conclusions: RT was the conventional treatment modality for orbital MALT lymphoma. Currently, RT is performed for the entire involved subsites at a lower dose than that previously used, and lens shielding was applied to minimize the orbital complication.",
author = "Jeongshim Lee and Dongryul Oh and Choi, {Byung Ock} and Eom, {Keun Yong} and Lee, {Jong Hoon} and Kim, {Jung Hoon} and Lee, {Sang Wook} and Suh, {Yang Kwon} and Suh, {Chang Ok}",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/ajco.13221",
language = "English",
journal = "Asia-Pacific Journal of Clinical Oncology",
issn = "1743-7555",
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Patterns of care for orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in Korea throughout 2016 : Results from a multicenter cross-sectional cohort study (KROG 16–19). / Lee, Jeongshim; Oh, Dongryul; Choi, Byung Ock; Eom, Keun Yong; Lee, Jong Hoon; Kim, Jung Hoon; Lee, Sang Wook; Suh, Yang Kwon; Suh, Chang Ok.

In: Asia-Pacific Journal of Clinical Oncology, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Patterns of care for orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in Korea throughout 2016

T2 - Results from a multicenter cross-sectional cohort study (KROG 16–19)

AU - Lee, Jeongshim

AU - Oh, Dongryul

AU - Choi, Byung Ock

AU - Eom, Keun Yong

AU - Lee, Jong Hoon

AU - Kim, Jung Hoon

AU - Lee, Sang Wook

AU - Suh, Yang Kwon

AU - Suh, Chang Ok

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: Primary orbital mucosa-associated lymphoid tissue (MALT) lymphomas are generally sensitive to radiotherapy (RT), but a “wait and see” strategy has also been used in asymptomatic patients. Recently, orbital MALT lymphoma has been reported to be associated with Chlamydia psittaci infection. This study aimed to assess the current patterns of care in clinical practice for orbital MALT lymphoma in South Korea. Methods: We performed a multicenter, cross-sectional cohort study of patterns of care for orbital MALT lymphoma in South Korea throughout 2016. All patients were pathologically confirmed to have orbital MALT lymphoma. Results: Overall, eight institutions with 90 patients participated. The survey showed that the most frequent upfront treatment for orbital MALT lymphoma was RT (80/90, 90%). Other treatment modalities were given to a limited number of orbital MALT lymphoma patients as follows: watch and wait, 6/90 (7%); antibiotics, 3/90 (3%) and chemotherapy, 1/90 (1%). Generally, RT was administered to the entire involved site such as the entire conjunctiva/eyelid or entire orbit (96%), with a median total dose of 25.2 Gy. Lens shielding was performed for most patients with conjunctival and eyelid tumors (93%). Conclusions: RT was the conventional treatment modality for orbital MALT lymphoma. Currently, RT is performed for the entire involved subsites at a lower dose than that previously used, and lens shielding was applied to minimize the orbital complication.

AB - Aim: Primary orbital mucosa-associated lymphoid tissue (MALT) lymphomas are generally sensitive to radiotherapy (RT), but a “wait and see” strategy has also been used in asymptomatic patients. Recently, orbital MALT lymphoma has been reported to be associated with Chlamydia psittaci infection. This study aimed to assess the current patterns of care in clinical practice for orbital MALT lymphoma in South Korea. Methods: We performed a multicenter, cross-sectional cohort study of patterns of care for orbital MALT lymphoma in South Korea throughout 2016. All patients were pathologically confirmed to have orbital MALT lymphoma. Results: Overall, eight institutions with 90 patients participated. The survey showed that the most frequent upfront treatment for orbital MALT lymphoma was RT (80/90, 90%). Other treatment modalities were given to a limited number of orbital MALT lymphoma patients as follows: watch and wait, 6/90 (7%); antibiotics, 3/90 (3%) and chemotherapy, 1/90 (1%). Generally, RT was administered to the entire involved site such as the entire conjunctiva/eyelid or entire orbit (96%), with a median total dose of 25.2 Gy. Lens shielding was performed for most patients with conjunctival and eyelid tumors (93%). Conclusions: RT was the conventional treatment modality for orbital MALT lymphoma. Currently, RT is performed for the entire involved subsites at a lower dose than that previously used, and lens shielding was applied to minimize the orbital complication.

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