Patterns of olfactory functional networks in Parkinson's disease dementia and Alzheimer's dementia

Yang Hyun Lee, Yunjin Bak, Chang hyun Park, Seok Jong Chung, Han Soo Yoo, Kyoungwon Baik, Jin Ho Jung, Young H. Sohn, Na Young Shin, Phil Hyu Lee

Research output: Contribution to journalArticle

Abstract

Hyposmia is common in Alzheimer's dementia (AD) and Parkinson's disease dementia (PDD). We evaluated the pattern of olfactory functional connectivity (FC) in AD and PDD to uncover neural correlates that are related to olfactory dysfunction. This study enrolled 57 patients with AD and PDD and 25 control subjects. Using a seed-based approach, we compared the resting-state network from the seed-region-of-interest in the olfactory bulb, olfactory tract, piriform cortex, and orbitofrontal cortex (OFC) between groups. The PDD group showed lower FC with striatal-thalamic-frontal regions from the olfactory bulb than the AD group. The PDD group showed lower FC from left OFC with striatal-frontal regions and lower FC from right OFC with left fronto-temporal areas than the AD group. In a correlation analysis, the FC from left OFC with right insula that differed between the PDD and control groups was positively correlated with olfactory function. The present study demonstrated that this distinct olfactory functional network pattern may represent different neural mechanisms for olfactory dysfunction in AD and PDD.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalNeurobiology of Aging
Volume89
DOIs
Publication statusPublished - 2020 May

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Lee, Y. H., Bak, Y., Park, C. H., Chung, S. J., Yoo, H. S., Baik, K., Jung, J. H., Sohn, Y. H., Shin, N. Y., & Lee, P. H. (2020). Patterns of olfactory functional networks in Parkinson's disease dementia and Alzheimer's dementia. Neurobiology of Aging, 89, 63-70. https://doi.org/10.1016/j.neurobiolaging.2019.12.021