PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation

Heon Yung Gee, Hyun Woo Park, Kyung Hwan Kim, Min Goo Lee

Research output: Contribution to journalShort survey

3 Citations (Scopus)

Abstract

Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.

Original languageEnglish
Pages (from-to)302-305
Number of pages4
JournalJournal of Medical Investigation
Volume56
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Vasoactive Intestinal Peptide Receptors
Anions
Epithelial Cells
Proteins
Ion Transport
Physiology
Ion Channels
Cystic Fibrosis
Scaffolds
Epithelium
Ions
Membranes
Molecules
Fluids

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

@article{e13a9db87d9949668f4eabcf6a4d49ad,
title = "PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation",
abstract = "Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.",
author = "Gee, {Heon Yung} and Park, {Hyun Woo} and Kim, {Kyung Hwan} and Lee, {Min Goo}",
year = "2009",
month = "12",
day = "1",
doi = "10.2152/jmi.56.302",
language = "English",
volume = "56",
pages = "302--305",
journal = "Journal of Medical Investigation",
issn = "1343-1420",
publisher = "University of Tokushima",
number = "SUPPL. 1",

}

PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation. / Gee, Heon Yung; Park, Hyun Woo; Kim, Kyung Hwan; Lee, Min Goo.

In: Journal of Medical Investigation, Vol. 56, No. SUPPL. 1, 01.12.2009, p. 302-305.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation

AU - Gee, Heon Yung

AU - Park, Hyun Woo

AU - Kim, Kyung Hwan

AU - Lee, Min Goo

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.

AB - Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.

UR - http://www.scopus.com/inward/record.url?scp=77749302268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749302268&partnerID=8YFLogxK

U2 - 10.2152/jmi.56.302

DO - 10.2152/jmi.56.302

M3 - Short survey

VL - 56

SP - 302

EP - 305

JO - Journal of Medical Investigation

JF - Journal of Medical Investigation

SN - 1343-1420

IS - SUPPL. 1

ER -