PEGylated magnetic nano-assemblies as contrast agents for effective T2-weighted MR imaging

Byunghoon Kang, Jaewoo Lim, Hye Young Son, Yuna Choi, Taejoon Kang, Juyeon Jung, yongmin Huh, Seungjoo Haam, Eun Kyung Lim

Research output: Contribution to journalArticle

Abstract

We designed a high-sensitivity magnetic resonance imaging contrast agent that could be used to diagnose diseases. First, magnetic nanocrystals were synthesized by a thermal decomposition method on an organic solvent to obtain a high magnetism and methoxy poly(ethylene glycol)-poly(lactic acid) as an amphiphilic polymer using the ring-opening polymerization method to stably disperse the magnetic nanocrystals in an aqueous phase. Subsequently, the magnetic nanoclusters simultaneously self-assembled with methoxy poly(ethylene glycol)-poly(lactic acid) using the nano-emulsion method to form magnetic nanoclusters. Because their shape was similar to a raspberry, they were named PEGylated magnetic nano-assemblies. The PEGylated magnetic nano-assemblies were dispersed stably in the aqueous phase with a uniform size of approximately 65–70 nm for an extended period (0 days: 68.8 ± 5.1 nm, 33 days: 69.2 ± 2.0 nm, and 44 days: 63.2 ± 5.6). They exhibited both enough of a magnetic resonance (MR) contrast effect and biocompatibility. In an in vivo study, the PEGylated magnetic nano-assemblies provided a high contrast effect for magnetic resonance images for a long time after one treatment, thereby improving the diagnostic visibility of the disease site.

Original languageEnglish
Article number410
JournalNanomaterials
Volume9
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

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Magnetic resonance
Contrast Media
Nanoclusters
Lactic acid
Imaging techniques
Nanocrystals
Polyethylene glycols
Ring opening polymerization
Magnetism
Emulsions
Biocompatibility
Visibility
Organic solvents
Polymers
Pyrolysis
poly(lactic acid-ethylene glycol)

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Materials Science(all)

Cite this

Kang, B., Lim, J., Son, H. Y., Choi, Y., Kang, T., Jung, J., ... Lim, E. K. (2019). PEGylated magnetic nano-assemblies as contrast agents for effective T2-weighted MR imaging. Nanomaterials, 9(3), [410]. https://doi.org/10.3390/nano9030410
Kang, Byunghoon ; Lim, Jaewoo ; Son, Hye Young ; Choi, Yuna ; Kang, Taejoon ; Jung, Juyeon ; Huh, yongmin ; Haam, Seungjoo ; Lim, Eun Kyung. / PEGylated magnetic nano-assemblies as contrast agents for effective T2-weighted MR imaging. In: Nanomaterials. 2019 ; Vol. 9, No. 3.
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PEGylated magnetic nano-assemblies as contrast agents for effective T2-weighted MR imaging. / Kang, Byunghoon; Lim, Jaewoo; Son, Hye Young; Choi, Yuna; Kang, Taejoon; Jung, Juyeon; Huh, yongmin; Haam, Seungjoo; Lim, Eun Kyung.

In: Nanomaterials, Vol. 9, No. 3, 410, 01.03.2019.

Research output: Contribution to journalArticle

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