PEGylated magnetic nano-assemblies as contrast agents for effective T2-weighted MR imaging

Byunghoon Kang, Jaewoo Lim, Hye Young Son, Yuna Choi, Taejoon Kang, Juyeon Jung, Yong Min Huh, Seungjoo Haam, Eun Kyung Lim

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3 Citations (Scopus)

Abstract

We designed a high-sensitivity magnetic resonance imaging contrast agent that could be used to diagnose diseases. First, magnetic nanocrystals were synthesized by a thermal decomposition method on an organic solvent to obtain a high magnetism and methoxy poly(ethylene glycol)-poly(lactic acid) as an amphiphilic polymer using the ring-opening polymerization method to stably disperse the magnetic nanocrystals in an aqueous phase. Subsequently, the magnetic nanoclusters simultaneously self-assembled with methoxy poly(ethylene glycol)-poly(lactic acid) using the nano-emulsion method to form magnetic nanoclusters. Because their shape was similar to a raspberry, they were named PEGylated magnetic nano-assemblies. The PEGylated magnetic nano-assemblies were dispersed stably in the aqueous phase with a uniform size of approximately 65–70 nm for an extended period (0 days: 68.8 ± 5.1 nm, 33 days: 69.2 ± 2.0 nm, and 44 days: 63.2 ± 5.6). They exhibited both enough of a magnetic resonance (MR) contrast effect and biocompatibility. In an in vivo study, the PEGylated magnetic nano-assemblies provided a high contrast effect for magnetic resonance images for a long time after one treatment, thereby improving the diagnostic visibility of the disease site.

Original languageEnglish
Article number410
JournalNanomaterials
Volume9
Issue number3
DOIs
Publication statusPublished - 2019 Mar

Bibliographical note

Funding Information:
This work was supported by the Center for BioNano HealthGuard funded by the Ministry of Science and ICT (MSIT) as Global Frontier Project (H-GUARD_2014M3A6B2060507 and HGUARD_2013M3A6B2078950), the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by MSIT (NRF-2018M3A9E2022821),the Basic Science Research Program of the NRF funded by MSIT (NRF2018R1C1B6005424 and NRF-2019R1C1C1006867), and KRIBB Research Initiative Program.

Funding Information:
Supplementary Materials: The following are available online at http://www.mdpi.com/2079-4991/9/3/410/s1. Supplementary Materials: The following are available online at www.mdpi.com/xxx/s1. Figure S1: The size analysis graphs of PEGylated MNs over 44 days (a): 0 day, b): 30 day and c): 44day). All measurements were Author Contributions: E.-K.L., S.H., and Y.-M.H. conceived and designed the experiments; B.K., Y.C., and H.-Y.S. performed the experiments; H.-Y.S. and Y.-M.H. analyzed the data; T.K. and J.J. contributed the reagents/materials/analysis tools. Author Contributions: E.-K.L., S.H., and Y.-M.H. conceived and designed the experiments; B.K., Y.C., and H.-FYu.Sn.dipnegrf:oTrhmisedw otrhke weaxspseuripmpeonrttes;d Hby.-tYh.eS.Caenndte rYfo.-rMB.iHoN. aannoalHyzeeadlt htGheuadrdatfau;nTd.eKd.bayntdh eJ.MJ.inciosntrtyribouftSecdie nthcee and ICT (MSIT) as Global Frontier Project (H-GUARD_2014M3A6B2060507 and HGUARD_2013M3A6B2078950), reagents/materials/analysis tools. the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded bFyunMdiSnIgT: T(NhiRs Fw-2o0r1k8 wMa3sA su9Ep2p0o2r2te8d2 1b)y, tthhee CBeanstiecr Sfocrie BnicoeNaRneose HarecahlthPGrougarradm funodfetdh ebyN thReF Mfuinnidsterdy obfy ScMieSnIcTe (NRF2018R1C1B6005424 and NRF-2019R1C1C1006867), and KRIBB Research Initiative Program.

Funding Information:
CHoGnUflAicRtsDo_f2I0n1t3eMre3stA: 6TBh2e0a7u89th5o0r),s tdheec Blaiore &n Mo ceodnicflaicl tToefchinntoelroegsty. Development Program of the National Research Foundation (NRF) funded by MSIT (NRF-2018M3A9E2022821), the Basic Science Research Program of the NRF

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Materials Science(all)

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