TY - JOUR
T1 - Pemetrexed and cisplatin in patients with advanced gastric cancer
T2 - A Korean cancer study group multicenter phase II study
AU - Kim, Yeul Hong
AU - Chung, Hyun Cheol
AU - Kang, Won Ki
AU - Park, Sook Ryun
AU - Kim, Chul Soo
AU - Kim, Tae Yue
AU - Shin, Sang Won
AU - Park, Byung Joo
AU - Cha, Soo Jin
AU - Bang, Yung Jue
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/7
Y1 - 2008/7
N2 - Background: Pemetrexed is a multitargeted antifolate enzyme inhibitor, which has activity against a variety of tumors, including advanced gastric cancer (AGC). The aim of this study was to assess efficacy and safety of pemetrexed plus cisplatin (PemCis) combination in the treatment of AGC in Korean patients. Patients and methods: This was a multicenter, single arm, open label study. Patients with no prior palliative chemotherapy received pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 day 1, every 3 weeks plus folic acid and vitamin B12 supplementation. Response rate was assessed according to response evaluation criteria in solid tumors (RECIST) criteria. Results: Of the 50 patients evaluable for efficacy, 13 had partial response for an overall response rate of 26% (95% CI, 14.6-40.3%) and 15 (30%) had stable disease. Median time to progression was 2.8 months (95%CI, 2.2-4.4 months), and median overall survival was 6.6 months (95% CI, 4.8-10.4 months). Of the 51 patients evaluable for safety, the most frequent NCI-CTC grade 3/4 toxicities were neutropenia in 49% of patients (25% of cycles) and anorexia in 10% of patients (4% of cycles). Conclusion: PemCis has a modest activity and acceptable toxicity profile in patients with AGC. Clinical trials with different combinations and dose regimens are, therefore, warranted.
AB - Background: Pemetrexed is a multitargeted antifolate enzyme inhibitor, which has activity against a variety of tumors, including advanced gastric cancer (AGC). The aim of this study was to assess efficacy and safety of pemetrexed plus cisplatin (PemCis) combination in the treatment of AGC in Korean patients. Patients and methods: This was a multicenter, single arm, open label study. Patients with no prior palliative chemotherapy received pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 day 1, every 3 weeks plus folic acid and vitamin B12 supplementation. Response rate was assessed according to response evaluation criteria in solid tumors (RECIST) criteria. Results: Of the 50 patients evaluable for efficacy, 13 had partial response for an overall response rate of 26% (95% CI, 14.6-40.3%) and 15 (30%) had stable disease. Median time to progression was 2.8 months (95%CI, 2.2-4.4 months), and median overall survival was 6.6 months (95% CI, 4.8-10.4 months). Of the 51 patients evaluable for safety, the most frequent NCI-CTC grade 3/4 toxicities were neutropenia in 49% of patients (25% of cycles) and anorexia in 10% of patients (4% of cycles). Conclusion: PemCis has a modest activity and acceptable toxicity profile in patients with AGC. Clinical trials with different combinations and dose regimens are, therefore, warranted.
UR - http://www.scopus.com/inward/record.url?scp=43949126887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43949126887&partnerID=8YFLogxK
U2 - 10.1007/s00280-007-0600-y
DO - 10.1007/s00280-007-0600-y
M3 - Article
C2 - 17960386
AN - SCOPUS:43949126887
VL - 62
SP - 263
EP - 270
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology
SN - 0344-5704
IS - 2
ER -