Penile vibratory threshold changes with various doses of SS-cream in patients with primary premature ejaculation

Zhong Cheng Xin, Young Deuk Choi, Woong Hee Lee, Yeong Jin Choi, Wing Jae Yang, Hyung Ki Choi, Dong Kee Kim

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


SS-cream made with extracts from natural products is a topical agent for treating premature ejaculation (PE). In order to elucidate the penile vibratory threshold changes and clinical effects of various doses of SS- cream, 53 patients with primary PE were investigated in a double-blind randomized placebo-controlled study. The mean age was 37.3 ± 6.4 years and mean ejaculatory latency was 1.37 ± 0.52 minutes. Neither the patients nor their sexual partners were satisfied with their sexual lives. Vibratory threshold at the glans penis, penile shaft, scrotum and index finger were measured using a biothesiometer twice during the screening period and three times one hour after the application of respective creams (SS-cream 0.05, 0.10, 0.15, 0.20 gm and placebo 0.10 gm) on the glans penis according to the order of the allocation table in a randomized fashion. The efficacy of SS- cream was defined as when the vibration threshold increased by more than 4 microns compared to the value tested during the screening period. The vibratory thresholds at the glans penis increased significantly in a dose- dependent manner after the application of various doses (0.05, 0.10, 0.15, 0.20 gm) of SS-cream (p<0.001), and the efficacy of SS-cream on the penile vibration threshold increased according to the increased dosage (penile shaft: 48.4, 51.6, 54.8, 64.5%, glans penis: 58.1, 67.7, 77.4, 83.9%, respectively). With these results, we concluded that SS-cream increased the penile sensory threshold dose dependently, and therefore it is clinically effective for treating the heightened penile sensory response in patients with PE.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalYonsei medical journal
Issue number1
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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