Percent tumor volume predicts biochemical recurrence after radical prostatectomy: Multi-institutional data analysis

Cheryn Song, Seongil Seo, Hanjong Ahn, Seok Soo Byun, Jin Seon Cho, Young Deuk Choi, Eunsik Lee, Hyun Moo Lee, Sang Eun Lee, Han Yong Choi

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18 Citations (Scopus)

Abstract

Background To investigate the prognostic significance of percent tumor volume (PTV) in relation to the surgical margin status in men with prostate cancer after radical prostatectomy (RP). Methods Clinical and pathological data from 1,567 patients treated with RP only between 1995 and 2007 at participating institutions were reviewed. PTV was determined by the sum of all visually estimated tumor foci on every section. Biochemical recurrence (BCR) was defined as 2 consecutive increases in prostate-specific antigen (PSA) >0.2 ng/ml and various clinicopathological variables were tested for prognostication of recurrence-free survival. Results Serum PSA at surgery was 12.5 ± 16.8 ng/ml and pathological stage was T2 in 899 (57.4%) patients. Surgical Gleason score was 7 in 842 patients (53.7%), higher than 7 in 250 (16%) patients, and in 32% of the patients, surgical margin was positive. Mean PTV was 15.7% and demonstrated a significant positive correlation with serum PSA, all pathological variables and BCR. On multivariate analysis, preoperative PSA (p = 0.012), surgical Gleason score (p<0.0001, HR 2.183, 95% CI 1.778-2.681), and PTV (≥5, 5.1-15, >15%; p<0.0001, HR 1.393, 95% CI 1.183-1.641) were independently prognostic of recurrence-free survival. Pathological stage demonstrated a significant relationship with BCR but was not independently prognostic in the multivariate model. Conclusion In men with prostate cancer, preoperative PSA, surgical Gleason score, and PTV are independent predictors of recurrence-free survival after RP.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalInternational Journal of Clinical Oncology
Volume17
Issue number4
DOIs
Publication statusPublished - 2012 Aug 1

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Prostatectomy
Tumor Burden
Prostate-Specific Antigen
Recurrence
Neoplasm Grading
Prostatic Neoplasms
Survival
Serum
Multivariate Analysis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hematology
  • Oncology

Cite this

Song, Cheryn ; Seo, Seongil ; Ahn, Hanjong ; Byun, Seok Soo ; Cho, Jin Seon ; Choi, Young Deuk ; Lee, Eunsik ; Lee, Hyun Moo ; Lee, Sang Eun ; Choi, Han Yong. / Percent tumor volume predicts biochemical recurrence after radical prostatectomy : Multi-institutional data analysis. In: International Journal of Clinical Oncology. 2012 ; Vol. 17, No. 4. pp. 355-360.
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title = "Percent tumor volume predicts biochemical recurrence after radical prostatectomy: Multi-institutional data analysis",
abstract = "Background To investigate the prognostic significance of percent tumor volume (PTV) in relation to the surgical margin status in men with prostate cancer after radical prostatectomy (RP). Methods Clinical and pathological data from 1,567 patients treated with RP only between 1995 and 2007 at participating institutions were reviewed. PTV was determined by the sum of all visually estimated tumor foci on every section. Biochemical recurrence (BCR) was defined as 2 consecutive increases in prostate-specific antigen (PSA) >0.2 ng/ml and various clinicopathological variables were tested for prognostication of recurrence-free survival. Results Serum PSA at surgery was 12.5 ± 16.8 ng/ml and pathological stage was T2 in 899 (57.4{\%}) patients. Surgical Gleason score was 7 in 842 patients (53.7{\%}), higher than 7 in 250 (16{\%}) patients, and in 32{\%} of the patients, surgical margin was positive. Mean PTV was 15.7{\%} and demonstrated a significant positive correlation with serum PSA, all pathological variables and BCR. On multivariate analysis, preoperative PSA (p = 0.012), surgical Gleason score (p<0.0001, HR 2.183, 95{\%} CI 1.778-2.681), and PTV (≥5, 5.1-15, >15{\%}; p<0.0001, HR 1.393, 95{\%} CI 1.183-1.641) were independently prognostic of recurrence-free survival. Pathological stage demonstrated a significant relationship with BCR but was not independently prognostic in the multivariate model. Conclusion In men with prostate cancer, preoperative PSA, surgical Gleason score, and PTV are independent predictors of recurrence-free survival after RP.",
author = "Cheryn Song and Seongil Seo and Hanjong Ahn and Byun, {Seok Soo} and Cho, {Jin Seon} and Choi, {Young Deuk} and Eunsik Lee and Lee, {Hyun Moo} and Lee, {Sang Eun} and Choi, {Han Yong}",
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Percent tumor volume predicts biochemical recurrence after radical prostatectomy : Multi-institutional data analysis. / Song, Cheryn; Seo, Seongil; Ahn, Hanjong; Byun, Seok Soo; Cho, Jin Seon; Choi, Young Deuk; Lee, Eunsik; Lee, Hyun Moo; Lee, Sang Eun; Choi, Han Yong.

In: International Journal of Clinical Oncology, Vol. 17, No. 4, 01.08.2012, p. 355-360.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Percent tumor volume predicts biochemical recurrence after radical prostatectomy

T2 - Multi-institutional data analysis

AU - Song, Cheryn

AU - Seo, Seongil

AU - Ahn, Hanjong

AU - Byun, Seok Soo

AU - Cho, Jin Seon

AU - Choi, Young Deuk

AU - Lee, Eunsik

AU - Lee, Hyun Moo

AU - Lee, Sang Eun

AU - Choi, Han Yong

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Background To investigate the prognostic significance of percent tumor volume (PTV) in relation to the surgical margin status in men with prostate cancer after radical prostatectomy (RP). Methods Clinical and pathological data from 1,567 patients treated with RP only between 1995 and 2007 at participating institutions were reviewed. PTV was determined by the sum of all visually estimated tumor foci on every section. Biochemical recurrence (BCR) was defined as 2 consecutive increases in prostate-specific antigen (PSA) >0.2 ng/ml and various clinicopathological variables were tested for prognostication of recurrence-free survival. Results Serum PSA at surgery was 12.5 ± 16.8 ng/ml and pathological stage was T2 in 899 (57.4%) patients. Surgical Gleason score was 7 in 842 patients (53.7%), higher than 7 in 250 (16%) patients, and in 32% of the patients, surgical margin was positive. Mean PTV was 15.7% and demonstrated a significant positive correlation with serum PSA, all pathological variables and BCR. On multivariate analysis, preoperative PSA (p = 0.012), surgical Gleason score (p<0.0001, HR 2.183, 95% CI 1.778-2.681), and PTV (≥5, 5.1-15, >15%; p<0.0001, HR 1.393, 95% CI 1.183-1.641) were independently prognostic of recurrence-free survival. Pathological stage demonstrated a significant relationship with BCR but was not independently prognostic in the multivariate model. Conclusion In men with prostate cancer, preoperative PSA, surgical Gleason score, and PTV are independent predictors of recurrence-free survival after RP.

AB - Background To investigate the prognostic significance of percent tumor volume (PTV) in relation to the surgical margin status in men with prostate cancer after radical prostatectomy (RP). Methods Clinical and pathological data from 1,567 patients treated with RP only between 1995 and 2007 at participating institutions were reviewed. PTV was determined by the sum of all visually estimated tumor foci on every section. Biochemical recurrence (BCR) was defined as 2 consecutive increases in prostate-specific antigen (PSA) >0.2 ng/ml and various clinicopathological variables were tested for prognostication of recurrence-free survival. Results Serum PSA at surgery was 12.5 ± 16.8 ng/ml and pathological stage was T2 in 899 (57.4%) patients. Surgical Gleason score was 7 in 842 patients (53.7%), higher than 7 in 250 (16%) patients, and in 32% of the patients, surgical margin was positive. Mean PTV was 15.7% and demonstrated a significant positive correlation with serum PSA, all pathological variables and BCR. On multivariate analysis, preoperative PSA (p = 0.012), surgical Gleason score (p<0.0001, HR 2.183, 95% CI 1.778-2.681), and PTV (≥5, 5.1-15, >15%; p<0.0001, HR 1.393, 95% CI 1.183-1.641) were independently prognostic of recurrence-free survival. Pathological stage demonstrated a significant relationship with BCR but was not independently prognostic in the multivariate model. Conclusion In men with prostate cancer, preoperative PSA, surgical Gleason score, and PTV are independent predictors of recurrence-free survival after RP.

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