Percutaneous Technique for Creation of Tricuspid Regurgitation in an Ovine Model

Hanno Hoppe; Dusan Pavcnik; Tim A. Chuter; Elaine Tseng; Man Deuk Kim; Ivo Bernat; Barry Uchida; Frederick S. Keller; Josef Rösch

doi:10.1016/j.jvir.2006.10.009

Percutaneous Technique for Creation of Tricuspid Regurgitation in an Ovine Model

Hanno Hoppe, Dusan Pavcnik, Tim A. Chuter, Elaine Tseng, Man Deuk Kim, Ivo Bernat, Barry Uchida, Frederick S. Keller, Josef Rösch

Department of Radiology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Experimental models of tricuspid regurgitation (TR) are needed to study the percutaneous placement of prosthetic atrioventricular valves. The purpose of this study was to develop an appropriate simple and reproducible percutaneous experimental model for creation of tricuspid regurgitation. Tricuspid regurgitation was successfully created through papillary muscle avulsion using a guide-wire loop in seven sheep with regurgitation documented on right ventricular angiograms and a significant increase in heart rate and right atrial pressures. Acute onset of tricuspid regurgitation was poorly tolerated in one animal that died. Autopsy examinations showed avulsion of one papillary muscle in four animals and two papillary muscles in three animals.

Original language	English
Pages (from-to)	133-136
Number of pages	4
Journal	Journal of Vascular and Interventional Radiology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.jvir.2006.10.009
Publication status	Published - 2007 Jan

Bibliographical note

Funding Information:
H.H. was supported by the Swiss National Foundation (SSMBS), Novartis Foundation Switzerland, and the Swiss Society of Radiology.

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.jvir.2006.10.009

Cite this

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title = "Percutaneous Technique for Creation of Tricuspid Regurgitation in an Ovine Model",

abstract = "Experimental models of tricuspid regurgitation (TR) are needed to study the percutaneous placement of prosthetic atrioventricular valves. The purpose of this study was to develop an appropriate simple and reproducible percutaneous experimental model for creation of tricuspid regurgitation. Tricuspid regurgitation was successfully created through papillary muscle avulsion using a guide-wire loop in seven sheep with regurgitation documented on right ventricular angiograms and a significant increase in heart rate and right atrial pressures. Acute onset of tricuspid regurgitation was poorly tolerated in one animal that died. Autopsy examinations showed avulsion of one papillary muscle in four animals and two papillary muscles in three animals.",

author = "Hanno Hoppe and Dusan Pavcnik and Chuter, {Tim A.} and Elaine Tseng and Kim, {Man Deuk} and Ivo Bernat and Barry Uchida and Keller, {Frederick S.} and Josef R{\"o}sch",

note = "Funding Information: H.H. was supported by the Swiss National Foundation (SSMBS), Novartis Foundation Switzerland, and the Swiss Society of Radiology.",

year = "2007",

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doi = "10.1016/j.jvir.2006.10.009",

language = "English",

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AU - Hoppe, Hanno

AU - Pavcnik, Dusan

AU - Chuter, Tim A.

AU - Tseng, Elaine

AU - Kim, Man Deuk

AU - Bernat, Ivo

AU - Uchida, Barry

AU - Keller, Frederick S.

AU - Rösch, Josef

N1 - Funding Information: H.H. was supported by the Swiss National Foundation (SSMBS), Novartis Foundation Switzerland, and the Swiss Society of Radiology.

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AB - Experimental models of tricuspid regurgitation (TR) are needed to study the percutaneous placement of prosthetic atrioventricular valves. The purpose of this study was to develop an appropriate simple and reproducible percutaneous experimental model for creation of tricuspid regurgitation. Tricuspid regurgitation was successfully created through papillary muscle avulsion using a guide-wire loop in seven sheep with regurgitation documented on right ventricular angiograms and a significant increase in heart rate and right atrial pressures. Acute onset of tricuspid regurgitation was poorly tolerated in one animal that died. Autopsy examinations showed avulsion of one papillary muscle in four animals and two papillary muscles in three animals.

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Percutaneous Technique for Creation of Tricuspid Regurgitation in an Ovine Model

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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