Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

Ya Zhi Zhang; Xiao Wen Zeng; Zhengmin (Min) Qian; Michael G. Vaughn; Sarah Dee Geiger; Li Wen Hu; Long Lu; Chuanxi Fu; Guang Hui Dong

doi:10.1007/s11356-017-8954-0

Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

Ya Zhi Zhang, Xiao Wen Zeng, Zhengmin (Min) Qian, Michael G. Vaughn, Sarah Dee Geiger, Li Wen Hu, Long Lu, Chuanxi Fu, Guang Hui Dong

Graduate School of Social Welfare

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

Original language	English
Pages (from-to)	13626-13637
Number of pages	12
Journal	Environmental Science and Pollution Research
Volume	24
Issue number	15
DOIs	https://doi.org/10.1007/s11356-017-8954-0
Publication status	Published - 2017 May 1

Bibliographical note

Funding Information:
This work was supported by Grants from the National Natural Science Foundation of China (No. 81472936, No. 81172630, and No. 81673127), the Fundamental Research Funds for the Central Universities (No. 16ykzd02), and the Guangdong Province Natural Science Foundation (No. 2014A030313021 and No. 2016A0303342). The views expressed in this article are those of the authors and do not necessarily represent those of the funding source. The funding source had no role in the design or analysis of the study publication.

All Science Journal Classification (ASJC) codes

Environmental Chemistry
Pollution
Health, Toxicology and Mutagenesis

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@article{85368dbc652148d1a6b0c3ccdb8fb642,

title = "Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China",

abstract = "Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.",

author = "Zhang, {Ya Zhi} and Zeng, {Xiao Wen} and Qian, {Zhengmin (Min)} and Vaughn, {Michael G.} and Geiger, {Sarah Dee} and Hu, {Li Wen} and Long Lu and Chuanxi Fu and Dong, {Guang Hui}",

note = "Funding Information: This work was supported by Grants from the National Natural Science Foundation of China (No. 81472936, No. 81172630, and No. 81673127), the Fundamental Research Funds for the Central Universities (No. 16ykzd02), and the Guangdong Province Natural Science Foundation (No. 2014A030313021 and No. 2016A0303342). The views expressed in this article are those of the authors and do not necessarily represent those of the funding source. The funding source had no role in the design or analysis of the study publication.",

year = "2017",

month = may,

day = "1",

doi = "10.1007/s11356-017-8954-0",

language = "English",

volume = "24",

pages = "13626--13637",

journal = "Environmental Science and Pollution Research",

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Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China. / Zhang, Ya Zhi; Zeng, Xiao Wen; Qian, Zhengmin (Min); Vaughn, Michael G.; Geiger, Sarah Dee; Hu, Li Wen; Lu, Long; Fu, Chuanxi; Dong, Guang Hui.

In: Environmental Science and Pollution Research, Vol. 24, No. 15, 01.05.2017, p. 13626-13637.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

AU - Zhang, Ya Zhi

AU - Zeng, Xiao Wen

AU - Qian, Zhengmin (Min)

AU - Vaughn, Michael G.

AU - Geiger, Sarah Dee

AU - Hu, Li Wen

AU - Lu, Long

AU - Fu, Chuanxi

AU - Dong, Guang Hui

N1 - Funding Information: This work was supported by Grants from the National Natural Science Foundation of China (No. 81472936, No. 81172630, and No. 81673127), the Fundamental Research Funds for the Central Universities (No. 16ykzd02), and the Guangdong Province Natural Science Foundation (No. 2014A030313021 and No. 2016A0303342). The views expressed in this article are those of the authors and do not necessarily represent those of the funding source. The funding source had no role in the design or analysis of the study publication.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

AB - Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

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