Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

Ya Zhi Zhang, Xiao Wen Zeng, Zhengmin (Min) Qian, Michael George Vaughn, Sarah Dee Geiger, Li Wen Hu, Long Lu, Chuanxi Fu, Guang Hui Dong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

Original languageEnglish
Pages (from-to)13626-13637
Number of pages12
JournalEnvironmental Science and Pollution Research
Volume24
Issue number15
DOIs
Publication statusPublished - 2017 May 1

Fingerprint

Umbilical Cord
Isomers
serum
China
Serum
Halogenation
Fluorination
Fetal Blood
sulfonate
Metabolism
Mothers
isomer
analysis
Blood
metabolism
blood
Population

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Zhang, Ya Zhi ; Zeng, Xiao Wen ; Qian, Zhengmin (Min) ; Vaughn, Michael George ; Geiger, Sarah Dee ; Hu, Li Wen ; Lu, Long ; Fu, Chuanxi ; Dong, Guang Hui. / Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China. In: Environmental Science and Pollution Research. 2017 ; Vol. 24, No. 15. pp. 13626-13637.
@article{85368dbc652148d1a6b0c3ccdb8fb642,
title = "Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China",
abstract = "Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50{\%} detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16{\%} of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70{\%} linear PFOS and 30{\%} branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69{\%} ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.",
author = "Zhang, {Ya Zhi} and Zeng, {Xiao Wen} and Qian, {Zhengmin (Min)} and Vaughn, {Michael George} and Geiger, {Sarah Dee} and Hu, {Li Wen} and Long Lu and Chuanxi Fu and Dong, {Guang Hui}",
year = "2017",
month = "5",
day = "1",
doi = "10.1007/s11356-017-8954-0",
language = "English",
volume = "24",
pages = "13626--13637",
journal = "Environmental Science and Pollution Research",
issn = "0944-1344",
publisher = "Springer Science + Business Media",
number = "15",

}

Zhang, YZ, Zeng, XW, Qian, ZM, Vaughn, MG, Geiger, SD, Hu, LW, Lu, L, Fu, C & Dong, GH 2017, 'Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China', Environmental Science and Pollution Research, vol. 24, no. 15, pp. 13626-13637. https://doi.org/10.1007/s11356-017-8954-0

Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China. / Zhang, Ya Zhi; Zeng, Xiao Wen; Qian, Zhengmin (Min); Vaughn, Michael George; Geiger, Sarah Dee; Hu, Li Wen; Lu, Long; Fu, Chuanxi; Dong, Guang Hui.

In: Environmental Science and Pollution Research, Vol. 24, No. 15, 01.05.2017, p. 13626-13637.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

AU - Zhang, Ya Zhi

AU - Zeng, Xiao Wen

AU - Qian, Zhengmin (Min)

AU - Vaughn, Michael George

AU - Geiger, Sarah Dee

AU - Hu, Li Wen

AU - Lu, Long

AU - Fu, Chuanxi

AU - Dong, Guang Hui

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

AB - Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

UR - http://www.scopus.com/inward/record.url?scp=85017098040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017098040&partnerID=8YFLogxK

U2 - 10.1007/s11356-017-8954-0

DO - 10.1007/s11356-017-8954-0

M3 - Article

VL - 24

SP - 13626

EP - 13637

JO - Environmental Science and Pollution Research

JF - Environmental Science and Pollution Research

SN - 0944-1344

IS - 15

ER -