Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer

Joon Seok Lim, Daehong Kim, Song Ee Baek, Sungmin Myoung, Junjeong Choi, Sang Joon Shin, Myeong Jin Kim, Nam Kyu Kim, Jinsuk Suh, Ki Whang Kim, Ki Chang Keum

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Abstract

Objectives To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer. Methods Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRTwere prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The Ktrans (volume transfer constant) and Ve (extracellular extravascular space fraction) were calculated. Results Before CRT, the mean tumour Ktrans in the downstaged group was significantly higher than that in the nondownstaged group (P00.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (P00.1392). Repeatedmeasures analysis of variance (ANOVA) showed significant differences for evolution of Ktrans values both between downstaged and non-downstaged groups (P00.0215) and between TRG responders and TRG non-responders (P00.0001). Regarding Ve, no significant differences were observed both between downstaged and non-downstaged groups (P00.689) or between TRG responders and TRG non-responders (P00.887). Conclusion Perfusion MRI of rectal cancer can be useful for assessing tumoural Ktrans changes by CRT. Tumours with high pre-CRT Ktrans values tended to respond favourably to CRT, particularly in terms of downstaging criteria. Key Points ̇ Perfusion MRI can now assess therapeutic response of tumours to therapy. ̇ Tumours with high initial Ktrans values responded favourably to chemoradiotherapy. ̇ Perfusion MRI of rectal cancer may help with decisions about management.

Original languageEnglish
Pages (from-to)1693-1700
Number of pages8
JournalEuropean Radiology
Volume22
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1

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Chemoradiotherapy
Rectal Neoplasms
Perfusion
Neoplasms
Therapeutics
Extracellular Space
Analysis of Variance
Biomarkers
Carcinoma

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lim, Joon Seok ; Kim, Daehong ; Baek, Song Ee ; Myoung, Sungmin ; Choi, Junjeong ; Shin, Sang Joon ; Kim, Myeong Jin ; Kim, Nam Kyu ; Suh, Jinsuk ; Kim, Ki Whang ; Keum, Ki Chang. / Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer. In: European Radiology. 2012 ; Vol. 22, No. 8. pp. 1693-1700.
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abstract = "Objectives To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer. Methods Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRTwere prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The Ktrans (volume transfer constant) and Ve (extracellular extravascular space fraction) were calculated. Results Before CRT, the mean tumour Ktrans in the downstaged group was significantly higher than that in the nondownstaged group (P00.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (P00.1392). Repeatedmeasures analysis of variance (ANOVA) showed significant differences for evolution of Ktrans values both between downstaged and non-downstaged groups (P00.0215) and between TRG responders and TRG non-responders (P00.0001). Regarding Ve, no significant differences were observed both between downstaged and non-downstaged groups (P00.689) or between TRG responders and TRG non-responders (P00.887). Conclusion Perfusion MRI of rectal cancer can be useful for assessing tumoural Ktrans changes by CRT. Tumours with high pre-CRT Ktrans values tended to respond favourably to CRT, particularly in terms of downstaging criteria. Key Points ̇ Perfusion MRI can now assess therapeutic response of tumours to therapy. ̇ Tumours with high initial Ktrans values responded favourably to chemoradiotherapy. ̇ Perfusion MRI of rectal cancer may help with decisions about management.",
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Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer. / Lim, Joon Seok; Kim, Daehong; Baek, Song Ee; Myoung, Sungmin; Choi, Junjeong; Shin, Sang Joon; Kim, Myeong Jin; Kim, Nam Kyu; Suh, Jinsuk; Kim, Ki Whang; Keum, Ki Chang.

In: European Radiology, Vol. 22, No. 8, 01.08.2012, p. 1693-1700.

Research output: Contribution to journalArticle

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T1 - Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer

AU - Lim, Joon Seok

AU - Kim, Daehong

AU - Baek, Song Ee

AU - Myoung, Sungmin

AU - Choi, Junjeong

AU - Shin, Sang Joon

AU - Kim, Myeong Jin

AU - Kim, Nam Kyu

AU - Suh, Jinsuk

AU - Kim, Ki Whang

AU - Keum, Ki Chang

PY - 2012/8/1

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N2 - Objectives To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer. Methods Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRTwere prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The Ktrans (volume transfer constant) and Ve (extracellular extravascular space fraction) were calculated. Results Before CRT, the mean tumour Ktrans in the downstaged group was significantly higher than that in the nondownstaged group (P00.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (P00.1392). Repeatedmeasures analysis of variance (ANOVA) showed significant differences for evolution of Ktrans values both between downstaged and non-downstaged groups (P00.0215) and between TRG responders and TRG non-responders (P00.0001). Regarding Ve, no significant differences were observed both between downstaged and non-downstaged groups (P00.689) or between TRG responders and TRG non-responders (P00.887). Conclusion Perfusion MRI of rectal cancer can be useful for assessing tumoural Ktrans changes by CRT. Tumours with high pre-CRT Ktrans values tended to respond favourably to CRT, particularly in terms of downstaging criteria. Key Points ̇ Perfusion MRI can now assess therapeutic response of tumours to therapy. ̇ Tumours with high initial Ktrans values responded favourably to chemoradiotherapy. ̇ Perfusion MRI of rectal cancer may help with decisions about management.

AB - Objectives To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer. Methods Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRTwere prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The Ktrans (volume transfer constant) and Ve (extracellular extravascular space fraction) were calculated. Results Before CRT, the mean tumour Ktrans in the downstaged group was significantly higher than that in the nondownstaged group (P00.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (P00.1392). Repeatedmeasures analysis of variance (ANOVA) showed significant differences for evolution of Ktrans values both between downstaged and non-downstaged groups (P00.0215) and between TRG responders and TRG non-responders (P00.0001). Regarding Ve, no significant differences were observed both between downstaged and non-downstaged groups (P00.689) or between TRG responders and TRG non-responders (P00.887). Conclusion Perfusion MRI of rectal cancer can be useful for assessing tumoural Ktrans changes by CRT. Tumours with high pre-CRT Ktrans values tended to respond favourably to CRT, particularly in terms of downstaging criteria. Key Points ̇ Perfusion MRI can now assess therapeutic response of tumours to therapy. ̇ Tumours with high initial Ktrans values responded favourably to chemoradiotherapy. ̇ Perfusion MRI of rectal cancer may help with decisions about management.

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