Abstract
This study evaluated the effect of oral triiodothyronine (T3) replacement therapy, starting on the day of the surgery, on thyroid hormone concentrations and clinical outcome in high-risk patients undergoing valvular heart surgery. Fifty patients were randomly allocated to either T3 or placebo. In the treatment (T3) group patients received 20 μg of oral or nasogastric T3 every 12 h starting just before induction of anaesthesia and until the first day after surgery. T3 concentrations were significantly higher in the T3 group than the placebo group from 1 to 36 h after removal of the aortic cross clamp. The number of patients requiring vasopressin after discontinuing cardiopulmonary bypass was significantly greater in the placebo group than the T3 group. Significantly fewer patients required vasopressors in the T3 group on the first day after surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 871-877 |
| Number of pages | 7 |
| Journal | Anaesthesia |
| Volume | 64 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2009 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Anesthesiology and Pain Medicine
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Peri-operative oral triiodothyronine replacement therapy to prevent postoperative low triiodothyronine state following valvular heart surgery. / Choi, Y. S.; Kwak, Y. L.; Kim, J. C.; Chun, D. H.; Hong, S. W.; Shim, Jae Kwang.
In: Anaesthesia, Vol. 64, No. 8, 01.08.2009, p. 871-877.Research output: Contribution to journal › Article
TY - JOUR
T1 - Peri-operative oral triiodothyronine replacement therapy to prevent postoperative low triiodothyronine state following valvular heart surgery
AU - Choi, Y. S.
AU - Kwak, Y. L.
AU - Kim, J. C.
AU - Chun, D. H.
AU - Hong, S. W.
AU - Shim, Jae Kwang
PY - 2009/8/1
Y1 - 2009/8/1
N2 - This study evaluated the effect of oral triiodothyronine (T3) replacement therapy, starting on the day of the surgery, on thyroid hormone concentrations and clinical outcome in high-risk patients undergoing valvular heart surgery. Fifty patients were randomly allocated to either T3 or placebo. In the treatment (T3) group patients received 20 μg of oral or nasogastric T3 every 12 h starting just before induction of anaesthesia and until the first day after surgery. T3 concentrations were significantly higher in the T3 group than the placebo group from 1 to 36 h after removal of the aortic cross clamp. The number of patients requiring vasopressin after discontinuing cardiopulmonary bypass was significantly greater in the placebo group than the T3 group. Significantly fewer patients required vasopressors in the T3 group on the first day after surgery.
AB - This study evaluated the effect of oral triiodothyronine (T3) replacement therapy, starting on the day of the surgery, on thyroid hormone concentrations and clinical outcome in high-risk patients undergoing valvular heart surgery. Fifty patients were randomly allocated to either T3 or placebo. In the treatment (T3) group patients received 20 μg of oral or nasogastric T3 every 12 h starting just before induction of anaesthesia and until the first day after surgery. T3 concentrations were significantly higher in the T3 group than the placebo group from 1 to 36 h after removal of the aortic cross clamp. The number of patients requiring vasopressin after discontinuing cardiopulmonary bypass was significantly greater in the placebo group than the T3 group. Significantly fewer patients required vasopressors in the T3 group on the first day after surgery.
UR - http://www.scopus.com/inward/record.url?scp=67650657835&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650657835&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2044.2009.05984.x
DO - 10.1111/j.1365-2044.2009.05984.x
M3 - Article
C2 - 19604191
AN - SCOPUS:67650657835
VL - 64
SP - 871
EP - 877
JO - Anaesthesia
JF - Anaesthesia
SN - 0003-2409
IS - 8
ER -