Periodic variation and its effect on management and prognosis of Korean patients with acute myocardial infarction

Hyo Eun Park, Bon Kwon Koo, Wonjae Lee, Youngjin Cho, Jin Sik Park, Ji Yong Choi, Myung Ho Jeong, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Chang Wook Nam, Jae Hwan Lee, Dong Hoon Choi, Taek Jong Hong, Jei Keon Chae, Jae Young Rhew, Kee Sik Kim, Hyo Soo Kim, Byung Hee Oh, Young Bae Park

Research output: Contribution to journalArticle

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Abstract

Background: The characteristics of the periodic variation in acute myocardial infarction (AMI) and the sub-sequent effect on management and prognosis have not been fully investigated in a large number of Asian populations. Methods and Results: From a prospective, observational multicenter online registry, 4,573 patients diagnosed as AMI in Korea from January to December 2006 were included. The highest incidence of AMI was between 8 a.m. and noon. The number of cases was highest in the winter and lowest in the autumn (13.6 vs 11.4 patients per day, P<0.001). Patients with symptom onset during working hours had a shorter time to first medical contact (203±288 min) compared with out-of-hours onset (230±288 min, P=0.003). In patients who underwent primary angioplasty, out-of hours symptom onset was associated with a greater time delay in both the patient's and the medical facility's response (door-to-balloon time out-of hours vs working hours: 101±54 min vs 84±44 min, P<0.001). In patients with ST-segment elevation myocardial infarction, symptoms to first medical contact showed a significant relationship to in-hospital mortality (for every 10 min of symptoms to first medical contact, odds ratio 1.006, 95% confidence interval 1.001-1.012, P=0.018) Conclusions: Circadian and periodic variation in AMI exists in Korean patients, which resulted in different patient behavior, hospital management and outcomes.

Original languageEnglish
Pages (from-to)970-976
Number of pages7
JournalCirculation Journal
Volume74
Issue number5
DOIs
Publication statusPublished - 2010 May 7

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Myocardial Infarction
Korea
Hospital Mortality
Angioplasty
Registries
Odds Ratio
Confidence Intervals
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Park, Hyo Eun ; Koo, Bon Kwon ; Lee, Wonjae ; Cho, Youngjin ; Park, Jin Sik ; Choi, Ji Yong ; Jeong, Myung Ho ; Kim, Jong Hyun ; Chae, Shung Chull ; Kim, Young Jo ; Nam, Chang Wook ; Lee, Jae Hwan ; Choi, Dong Hoon ; Hong, Taek Jong ; Chae, Jei Keon ; Rhew, Jae Young ; Kim, Kee Sik ; Kim, Hyo Soo ; Oh, Byung Hee ; Park, Young Bae. / Periodic variation and its effect on management and prognosis of Korean patients with acute myocardial infarction. In: Circulation Journal. 2010 ; Vol. 74, No. 5. pp. 970-976.
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title = "Periodic variation and its effect on management and prognosis of Korean patients with acute myocardial infarction",
abstract = "Background: The characteristics of the periodic variation in acute myocardial infarction (AMI) and the sub-sequent effect on management and prognosis have not been fully investigated in a large number of Asian populations. Methods and Results: From a prospective, observational multicenter online registry, 4,573 patients diagnosed as AMI in Korea from January to December 2006 were included. The highest incidence of AMI was between 8 a.m. and noon. The number of cases was highest in the winter and lowest in the autumn (13.6 vs 11.4 patients per day, P<0.001). Patients with symptom onset during working hours had a shorter time to first medical contact (203±288 min) compared with out-of-hours onset (230±288 min, P=0.003). In patients who underwent primary angioplasty, out-of hours symptom onset was associated with a greater time delay in both the patient's and the medical facility's response (door-to-balloon time out-of hours vs working hours: 101±54 min vs 84±44 min, P<0.001). In patients with ST-segment elevation myocardial infarction, symptoms to first medical contact showed a significant relationship to in-hospital mortality (for every 10 min of symptoms to first medical contact, odds ratio 1.006, 95{\%} confidence interval 1.001-1.012, P=0.018) Conclusions: Circadian and periodic variation in AMI exists in Korean patients, which resulted in different patient behavior, hospital management and outcomes.",
author = "Park, {Hyo Eun} and Koo, {Bon Kwon} and Wonjae Lee and Youngjin Cho and Park, {Jin Sik} and Choi, {Ji Yong} and Jeong, {Myung Ho} and Kim, {Jong Hyun} and Chae, {Shung Chull} and Kim, {Young Jo} and Nam, {Chang Wook} and Lee, {Jae Hwan} and Choi, {Dong Hoon} and Hong, {Taek Jong} and Chae, {Jei Keon} and Rhew, {Jae Young} and Kim, {Kee Sik} and Kim, {Hyo Soo} and Oh, {Byung Hee} and Park, {Young Bae}",
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Park, HE, Koo, BK, Lee, W, Cho, Y, Park, JS, Choi, JY, Jeong, MH, Kim, JH, Chae, SC, Kim, YJ, Nam, CW, Lee, JH, Choi, DH, Hong, TJ, Chae, JK, Rhew, JY, Kim, KS, Kim, HS, Oh, BH & Park, YB 2010, 'Periodic variation and its effect on management and prognosis of Korean patients with acute myocardial infarction', Circulation Journal, vol. 74, no. 5, pp. 970-976. https://doi.org/10.1253/circj.CJ-09-0344

Periodic variation and its effect on management and prognosis of Korean patients with acute myocardial infarction. / Park, Hyo Eun; Koo, Bon Kwon; Lee, Wonjae; Cho, Youngjin; Park, Jin Sik; Choi, Ji Yong; Jeong, Myung Ho; Kim, Jong Hyun; Chae, Shung Chull; Kim, Young Jo; Nam, Chang Wook; Lee, Jae Hwan; Choi, Dong Hoon; Hong, Taek Jong; Chae, Jei Keon; Rhew, Jae Young; Kim, Kee Sik; Kim, Hyo Soo; Oh, Byung Hee; Park, Young Bae.

In: Circulation Journal, Vol. 74, No. 5, 07.05.2010, p. 970-976.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Periodic variation and its effect on management and prognosis of Korean patients with acute myocardial infarction

AU - Park, Hyo Eun

AU - Koo, Bon Kwon

AU - Lee, Wonjae

AU - Cho, Youngjin

AU - Park, Jin Sik

AU - Choi, Ji Yong

AU - Jeong, Myung Ho

AU - Kim, Jong Hyun

AU - Chae, Shung Chull

AU - Kim, Young Jo

AU - Nam, Chang Wook

AU - Lee, Jae Hwan

AU - Choi, Dong Hoon

AU - Hong, Taek Jong

AU - Chae, Jei Keon

AU - Rhew, Jae Young

AU - Kim, Kee Sik

AU - Kim, Hyo Soo

AU - Oh, Byung Hee

AU - Park, Young Bae

PY - 2010/5/7

Y1 - 2010/5/7

N2 - Background: The characteristics of the periodic variation in acute myocardial infarction (AMI) and the sub-sequent effect on management and prognosis have not been fully investigated in a large number of Asian populations. Methods and Results: From a prospective, observational multicenter online registry, 4,573 patients diagnosed as AMI in Korea from January to December 2006 were included. The highest incidence of AMI was between 8 a.m. and noon. The number of cases was highest in the winter and lowest in the autumn (13.6 vs 11.4 patients per day, P<0.001). Patients with symptom onset during working hours had a shorter time to first medical contact (203±288 min) compared with out-of-hours onset (230±288 min, P=0.003). In patients who underwent primary angioplasty, out-of hours symptom onset was associated with a greater time delay in both the patient's and the medical facility's response (door-to-balloon time out-of hours vs working hours: 101±54 min vs 84±44 min, P<0.001). In patients with ST-segment elevation myocardial infarction, symptoms to first medical contact showed a significant relationship to in-hospital mortality (for every 10 min of symptoms to first medical contact, odds ratio 1.006, 95% confidence interval 1.001-1.012, P=0.018) Conclusions: Circadian and periodic variation in AMI exists in Korean patients, which resulted in different patient behavior, hospital management and outcomes.

AB - Background: The characteristics of the periodic variation in acute myocardial infarction (AMI) and the sub-sequent effect on management and prognosis have not been fully investigated in a large number of Asian populations. Methods and Results: From a prospective, observational multicenter online registry, 4,573 patients diagnosed as AMI in Korea from January to December 2006 were included. The highest incidence of AMI was between 8 a.m. and noon. The number of cases was highest in the winter and lowest in the autumn (13.6 vs 11.4 patients per day, P<0.001). Patients with symptom onset during working hours had a shorter time to first medical contact (203±288 min) compared with out-of-hours onset (230±288 min, P=0.003). In patients who underwent primary angioplasty, out-of hours symptom onset was associated with a greater time delay in both the patient's and the medical facility's response (door-to-balloon time out-of hours vs working hours: 101±54 min vs 84±44 min, P<0.001). In patients with ST-segment elevation myocardial infarction, symptoms to first medical contact showed a significant relationship to in-hospital mortality (for every 10 min of symptoms to first medical contact, odds ratio 1.006, 95% confidence interval 1.001-1.012, P=0.018) Conclusions: Circadian and periodic variation in AMI exists in Korean patients, which resulted in different patient behavior, hospital management and outcomes.

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DO - 10.1253/circj.CJ-09-0344

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JO - Circulation Journal

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