TY - JOUR
T1 - Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect
T2 - A histologic study in dogs
AU - Lee, Jung Seok
AU - Park, Weon Yeong
AU - Cha, Jae Kook
AU - Jung, Ui Won
AU - Kim, Chang Sung
AU - Lee, Yong Keun
AU - Choi, Seong Ho
PY - 2012/4
Y1 - 2012/4
N2 - Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n- HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
AB - Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n- HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
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U2 - 10.5051/jpis.2012.42.2.50
DO - 10.5051/jpis.2012.42.2.50
M3 - Article
C2 - 22586523
AN - SCOPUS:84865337684
VL - 42
SP - 50
EP - 58
JO - Journal of Periodontal and Implant Science
JF - Journal of Periodontal and Implant Science
SN - 2093-2278
IS - 2
ER -