Abstract
Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n- HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 50-58 |
| Number of pages | 9 |
| Journal | Journal of Periodontal and Implant Science |
| Volume | 42 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Oral Surgery
- Periodontics
Cite this
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Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect : A histologic study in dogs. / Lee, Jung Seok; Park, Weon Yeong; Cha, Jae Kook; Jung, Ui Won; Kim, Chang Sung; Lee, Yong Keun; Choi, Seong Ho.
In: Journal of Periodontal and Implant Science, Vol. 42, No. 2, 01.04.2012, p. 50-58.Research output: Contribution to journal › Article
TY - JOUR
T1 - Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect
T2 - A histologic study in dogs
AU - Lee, Jung Seok
AU - Park, Weon Yeong
AU - Cha, Jae Kook
AU - Jung, Ui Won
AU - Kim, Chang Sung
AU - Lee, Yong Keun
AU - Choi, Seong Ho
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n- HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
AB - Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n- HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
UR - http://www.scopus.com/inward/record.url?scp=84865337684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865337684&partnerID=8YFLogxK
U2 - 10.5051/jpis.2012.42.2.50
DO - 10.5051/jpis.2012.42.2.50
M3 - Article
C2 - 22586523
AN - SCOPUS:84865337684
VL - 42
SP - 50
EP - 58
JO - Journal of Periodontal and Implant Science
JF - Journal of Periodontal and Implant Science
SN - 2093-2278
IS - 2
ER -