Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: A histologic study in dogs

Jung Seok Lee, Weon Yeong Park, Jae Kook Cha, Ui Won Jung, Chang Sung Kim, Yong Keun Lee, Seong Ho Choi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n- HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.

Original languageEnglish
Pages (from-to)50-58
Number of pages9
JournalJournal of Periodontal and Implant Science
Volume42
Issue number2
DOIs
Publication statusPublished - 2012 Apr 1

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Durapatite
Dogs
Bone and Bones
Bicuspid
Porifera
Tissue Engineering
Osteogenesis
Powders
Regeneration
Inflammation
Transplants

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Periodontics

Cite this

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title = "Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: A histologic study in dogs",
abstract = "Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n- HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.",
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Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect : A histologic study in dogs. / Lee, Jung Seok; Park, Weon Yeong; Cha, Jae Kook; Jung, Ui Won; Kim, Chang Sung; Lee, Yong Keun; Choi, Seong Ho.

In: Journal of Periodontal and Implant Science, Vol. 42, No. 2, 01.04.2012, p. 50-58.

Research output: Contribution to journalArticle

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AU - Jung, Ui Won

AU - Kim, Chang Sung

AU - Lee, Yong Keun

AU - Choi, Seong Ho

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