Perioperative blood transfusions and prognosis in patients with curatively resected locally advanced gastric Cancer

Jin Hyuk Choi, Hyun Cheol Chung, Nae Chun Yoo, Hye Ran Lee, Kyung Hee Lee, Joo Hang Kim, Jae Kyung Roh, Jin Sik Min, Kyong Sik Lee, Byung Soo Kim, Ho Yeong Lim

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Abstract

Several reports have demonstrated an adverse effect of perioperative blood transfusions on the survival of patients with various solid tumors treated surgically. We retrospectively investigated the relationship between perioperative blood transfusions and the survival of 501 patients who underwent radical subtotal gastrectomy for locally advanced gastric cancer (stage II-IIIB) from January 1984 to December 1989. Three hundred and fifty-two patients (70.3%) received blood transfusions within the perioperative period. The transfused group included patients with tumors of larger size (5.1 vs. 4.4 cm, p = 0.001) and more advanced stage (stage IIIB: 27.6 vs. 10.7%, p = 0.0001) than the nontransfused group. Although the 5-year overall survival rate was significantly lower (52.9 vs. 66.7%, p = 0.026) in the transfused patients than the nontransfused, subgroup analysis according to the pathologic stage showed no statistically significant difference in survival in each stage between the two groups. In conclusion, we could not find any causal relationships between transfusion and prognosis in patients with curatively resected locally advanced gastric cancer. Circumstances such as advanced stage necessitating transfusions may be more important prognostic factors.

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalOncology (Switzerland)
Volume52
Issue number2
DOIs
Publication statusPublished - 1995 Jan 1

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Choi, J. H., Chung, H. C., Yoo, N. C., Lee, H. R., Lee, K. H., Kim, J. H., Roh, J. K., Min, J. S., Lee, K. S., Kim, B. S., & Lim, H. Y. (1995). Perioperative blood transfusions and prognosis in patients with curatively resected locally advanced gastric Cancer. Oncology (Switzerland), 52(2), 170-175. https://doi.org/10.1159/000227452