Peripheral cannabinoid 1 receptor blockade mitigates adipose tissue inflammation via NLRP3 inflammasome in mouse models of obesity

Ji H. Han, Hanho Shin, Jun G. Rho, Jung Eun Kim, Dong H. Son, Juhwan Yoon, Yong J. Lee, Jung Hyuck Park, Byung J. Song, Chang Sik Choi, Seul G. Yoon, Il Y. Kim, Eun K. Lee, Je K. Seong, Ki W. Kim, Wook Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Aim: To analyze the metabolic parameters and adipose tissue inflammation via NLRP3 inflammasome following chronic treatment of mouse models of obesity with AJ5018 as the peripherally restricted cannabinoid 1 receptor (CB1R) antagonist. Materials and methods: The selectivity for CB1R over CB2R, brain/plasma concentration ratio, and centrally mediated neurobehavioural effects of AJ5018, were assessed. The long-term effects of AJ5018 and rimonabant on the metabolic parameters and adipose tissue inflammation were analyzed in diet-induced obese (DIO) mice and diabetic db/db mice. Results: AJ5018 had a higher degree of selectivity for CB1R over CB2R and markedly reduced brain penetrance, as reflected by the lower brain/plasma concentration ratio and the attenuated centrally mediated neurobehavioural effects, compared with its brain-penetrant parent compound rimonabant. In DIO and db/db mice, AJ5018 exhibited comparable effects to rimonabant in improving metabolic abnormalities and suppressing macrophage infiltration into white adipose tissue, activation of the NLRP3 inflammasome, and production of proinflammatory cytokines. Conclusions: These results suggest that peripheral CB1R blockade improves obesity-induced insulin resistance by suppressing adipose tissue inflammation via the NLRP3 inflammasome.

Original languageEnglish
Pages (from-to)2179-2189
Number of pages11
JournalDiabetes, Obesity and Metabolism
Volume20
Issue number9
DOIs
Publication statusPublished - 2018 Sep

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2009–0093826) and the Ministry of Science, ICT & Future (2013M3A9D5072550 and 2016R1E1A1A01941213).

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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