Peripheral vasculature in portal hypertension is characterized by hyperdynamic circulation, decreased effective circulating volume, the peripheral venous ‘sump’ effect, and arterial splenic vasodilation. Also, the autonomic nervous system plays a key role in modulation of vasomotor activity. Pathogenetic mechanisms associated with hyperdynamic circulation are known as nitric oxide, endocannabinoids, humoral agents, bile acids, central neural activation, and inflammation. Several studies have reported strategies to reverse the abnormal change of peripheral vasculature in patients with portal hypertension.
|Title of host publication||Cardio-Hepatology|
|Subtitle of host publication||Connections Between Hepatic and Cardiovascular Disease|
|Number of pages||14|
|Publication status||Published - 2022 Jan 1|
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All Science Journal Classification (ASJC) codes
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)