Peritoneoscopic Liver Biopsy Findings in Asymptomatic Chronic HBsAg Carriers with Normal Liver Function Tests and No Hepatomegaly

Chae Yoon Chon, KwangHyub Han, Kwan Sik Lee, Young Myung Moon, Jin Kyung Kang, In Suh Park, Chanil Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Asymptomatic chronic HBsAg carriers with normal liver function tests are, in general, regarded as having no liver pathology. Most of the histologic findings in asymptomatic chronic carriers have been reported from areas with low incidence of Hepatitis B virus (HBV) infection, such as North America and Western Europe. It is well known that there are many differences in HBV infection between low and high endemic areas, but there have been few reports on the histologic findings of asymptomatic chronic HBsAg carriers from endemic areas. The present study was undertaken in Korea which is one of the endemic areas for HBV infection and was designed to assess the prevalence of chronic liver disease by peritoneoscopic liver biopsy among asymptomatic chronic HBsAg carriers and to make a basis for the follow-up of asymptomatic chronic HBsAg carriers according to the results obtained. One hundred and ten asymptomatic HBsAg-positive carriers with normal liver function tests and no hepatomegaly were included in the study. Final diagnosis by peritoneoscopic liver biopsy revealed that of the 110 asymptomatic carriers only 27 (24.5%) had a historically normal liver, while 51 (46.4%) had chronic liver diseases, and the remaining 32 (29.1%) had nonspecific histologic abnormalities (nonspecific reactive changes in 18 cases, cholestasis in 6 cases, and fatty change in 8 cases). Of the 51 patients with chronic liver diseases, 3 had liver cirrhosis, 4 chronic active hepatitis with cirrhosis, 11 chronic active hepatitis and 33 chronic persistent hepatitis. The frequency of liver cirrhosis and chronic active hepatitis with cirrhosis was significantly high in the over 30 years of age group (12.1%) than in the under 30 years of age group (0%; p=0.011 by Fisher's exact test). In conclusion, 46.4% of the Korean asymptomatic chronic HBsAg carriers with normal liver function tests and no hepatomegaly had chronic liver disease. This finding contrasted with reports from low incidence areas of HBV infection. Our results suggest that in endemic areas, a liver biopsy should be considered to assess the status of liver disease in asymptomatic chronic HBsAg carriers even if liver function tests are normal and hepatomegaly is absent, and the result can be used as a basis for the follow-up of each asymptomatic chronic HBsAg carriers.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalYonsei Medical Journal
Volume37
Issue number5
DOIs
Publication statusPublished - 1996 Jan 1

Fingerprint

Hepatomegaly
Liver Function Tests
Hepatitis B Surface Antigens
Biopsy
Liver
Liver Diseases
Virus Diseases
Chronic Hepatitis
Hepatitis B virus
Chronic Disease
Liver Cirrhosis
Fibrosis
Age Groups
Cholestasis
Incidence
Korea
North America
Pathology

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chon, Chae Yoon ; Han, KwangHyub ; Lee, Kwan Sik ; Moon, Young Myung ; Kang, Jin Kyung ; Park, In Suh ; Park, Chanil. / Peritoneoscopic Liver Biopsy Findings in Asymptomatic Chronic HBsAg Carriers with Normal Liver Function Tests and No Hepatomegaly. In: Yonsei Medical Journal. 1996 ; Vol. 37, No. 5. pp. 295-301.
@article{cfe56af201c5488391e07bd6cd490850,
title = "Peritoneoscopic Liver Biopsy Findings in Asymptomatic Chronic HBsAg Carriers with Normal Liver Function Tests and No Hepatomegaly",
abstract = "Asymptomatic chronic HBsAg carriers with normal liver function tests are, in general, regarded as having no liver pathology. Most of the histologic findings in asymptomatic chronic carriers have been reported from areas with low incidence of Hepatitis B virus (HBV) infection, such as North America and Western Europe. It is well known that there are many differences in HBV infection between low and high endemic areas, but there have been few reports on the histologic findings of asymptomatic chronic HBsAg carriers from endemic areas. The present study was undertaken in Korea which is one of the endemic areas for HBV infection and was designed to assess the prevalence of chronic liver disease by peritoneoscopic liver biopsy among asymptomatic chronic HBsAg carriers and to make a basis for the follow-up of asymptomatic chronic HBsAg carriers according to the results obtained. One hundred and ten asymptomatic HBsAg-positive carriers with normal liver function tests and no hepatomegaly were included in the study. Final diagnosis by peritoneoscopic liver biopsy revealed that of the 110 asymptomatic carriers only 27 (24.5{\%}) had a historically normal liver, while 51 (46.4{\%}) had chronic liver diseases, and the remaining 32 (29.1{\%}) had nonspecific histologic abnormalities (nonspecific reactive changes in 18 cases, cholestasis in 6 cases, and fatty change in 8 cases). Of the 51 patients with chronic liver diseases, 3 had liver cirrhosis, 4 chronic active hepatitis with cirrhosis, 11 chronic active hepatitis and 33 chronic persistent hepatitis. The frequency of liver cirrhosis and chronic active hepatitis with cirrhosis was significantly high in the over 30 years of age group (12.1{\%}) than in the under 30 years of age group (0{\%}; p=0.011 by Fisher's exact test). In conclusion, 46.4{\%} of the Korean asymptomatic chronic HBsAg carriers with normal liver function tests and no hepatomegaly had chronic liver disease. This finding contrasted with reports from low incidence areas of HBV infection. Our results suggest that in endemic areas, a liver biopsy should be considered to assess the status of liver disease in asymptomatic chronic HBsAg carriers even if liver function tests are normal and hepatomegaly is absent, and the result can be used as a basis for the follow-up of each asymptomatic chronic HBsAg carriers.",
author = "Chon, {Chae Yoon} and KwangHyub Han and Lee, {Kwan Sik} and Moon, {Young Myung} and Kang, {Jin Kyung} and Park, {In Suh} and Chanil Park",
year = "1996",
month = "1",
day = "1",
doi = "10.3349/ymj.1996.37.5.295",
language = "English",
volume = "37",
pages = "295--301",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "5",

}

Peritoneoscopic Liver Biopsy Findings in Asymptomatic Chronic HBsAg Carriers with Normal Liver Function Tests and No Hepatomegaly. / Chon, Chae Yoon; Han, KwangHyub; Lee, Kwan Sik; Moon, Young Myung; Kang, Jin Kyung; Park, In Suh; Park, Chanil.

In: Yonsei Medical Journal, Vol. 37, No. 5, 01.01.1996, p. 295-301.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Peritoneoscopic Liver Biopsy Findings in Asymptomatic Chronic HBsAg Carriers with Normal Liver Function Tests and No Hepatomegaly

AU - Chon, Chae Yoon

AU - Han, KwangHyub

AU - Lee, Kwan Sik

AU - Moon, Young Myung

AU - Kang, Jin Kyung

AU - Park, In Suh

AU - Park, Chanil

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Asymptomatic chronic HBsAg carriers with normal liver function tests are, in general, regarded as having no liver pathology. Most of the histologic findings in asymptomatic chronic carriers have been reported from areas with low incidence of Hepatitis B virus (HBV) infection, such as North America and Western Europe. It is well known that there are many differences in HBV infection between low and high endemic areas, but there have been few reports on the histologic findings of asymptomatic chronic HBsAg carriers from endemic areas. The present study was undertaken in Korea which is one of the endemic areas for HBV infection and was designed to assess the prevalence of chronic liver disease by peritoneoscopic liver biopsy among asymptomatic chronic HBsAg carriers and to make a basis for the follow-up of asymptomatic chronic HBsAg carriers according to the results obtained. One hundred and ten asymptomatic HBsAg-positive carriers with normal liver function tests and no hepatomegaly were included in the study. Final diagnosis by peritoneoscopic liver biopsy revealed that of the 110 asymptomatic carriers only 27 (24.5%) had a historically normal liver, while 51 (46.4%) had chronic liver diseases, and the remaining 32 (29.1%) had nonspecific histologic abnormalities (nonspecific reactive changes in 18 cases, cholestasis in 6 cases, and fatty change in 8 cases). Of the 51 patients with chronic liver diseases, 3 had liver cirrhosis, 4 chronic active hepatitis with cirrhosis, 11 chronic active hepatitis and 33 chronic persistent hepatitis. The frequency of liver cirrhosis and chronic active hepatitis with cirrhosis was significantly high in the over 30 years of age group (12.1%) than in the under 30 years of age group (0%; p=0.011 by Fisher's exact test). In conclusion, 46.4% of the Korean asymptomatic chronic HBsAg carriers with normal liver function tests and no hepatomegaly had chronic liver disease. This finding contrasted with reports from low incidence areas of HBV infection. Our results suggest that in endemic areas, a liver biopsy should be considered to assess the status of liver disease in asymptomatic chronic HBsAg carriers even if liver function tests are normal and hepatomegaly is absent, and the result can be used as a basis for the follow-up of each asymptomatic chronic HBsAg carriers.

AB - Asymptomatic chronic HBsAg carriers with normal liver function tests are, in general, regarded as having no liver pathology. Most of the histologic findings in asymptomatic chronic carriers have been reported from areas with low incidence of Hepatitis B virus (HBV) infection, such as North America and Western Europe. It is well known that there are many differences in HBV infection between low and high endemic areas, but there have been few reports on the histologic findings of asymptomatic chronic HBsAg carriers from endemic areas. The present study was undertaken in Korea which is one of the endemic areas for HBV infection and was designed to assess the prevalence of chronic liver disease by peritoneoscopic liver biopsy among asymptomatic chronic HBsAg carriers and to make a basis for the follow-up of asymptomatic chronic HBsAg carriers according to the results obtained. One hundred and ten asymptomatic HBsAg-positive carriers with normal liver function tests and no hepatomegaly were included in the study. Final diagnosis by peritoneoscopic liver biopsy revealed that of the 110 asymptomatic carriers only 27 (24.5%) had a historically normal liver, while 51 (46.4%) had chronic liver diseases, and the remaining 32 (29.1%) had nonspecific histologic abnormalities (nonspecific reactive changes in 18 cases, cholestasis in 6 cases, and fatty change in 8 cases). Of the 51 patients with chronic liver diseases, 3 had liver cirrhosis, 4 chronic active hepatitis with cirrhosis, 11 chronic active hepatitis and 33 chronic persistent hepatitis. The frequency of liver cirrhosis and chronic active hepatitis with cirrhosis was significantly high in the over 30 years of age group (12.1%) than in the under 30 years of age group (0%; p=0.011 by Fisher's exact test). In conclusion, 46.4% of the Korean asymptomatic chronic HBsAg carriers with normal liver function tests and no hepatomegaly had chronic liver disease. This finding contrasted with reports from low incidence areas of HBV infection. Our results suggest that in endemic areas, a liver biopsy should be considered to assess the status of liver disease in asymptomatic chronic HBsAg carriers even if liver function tests are normal and hepatomegaly is absent, and the result can be used as a basis for the follow-up of each asymptomatic chronic HBsAg carriers.

UR - http://www.scopus.com/inward/record.url?scp=0030253617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030253617&partnerID=8YFLogxK

U2 - 10.3349/ymj.1996.37.5.295

DO - 10.3349/ymj.1996.37.5.295

M3 - Article

C2 - 8997161

AN - SCOPUS:0030253617

VL - 37

SP - 295

EP - 301

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 5

ER -