Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury

Kang Ju Lee, Seung Hyun Park, Ji Yong Lee, Hyun Chel Joo, Eui Hwa Jang, Young Nam Youn, WonHyoung Ryu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Restenosis often occurs at the site of vascular grafting and may become fatal for patients. Restenosis at anastomosis sites is due to neointimal hyperplasia (NH) and difficult to treat with conventional treatments. Such abnormal growth of smooth muscle cells in tunica media of vascular tissue can be reduced by delivering anti-proliferation drugs such as paclitaxel (PTX) to the inner vascular layer. Drug eluting stents (DES) or drug eluting balloon (DEB) have been developed to treat such vascular diseases. However, they are less efficient in drug delivery due to the drug loss to blood stream and inadequate to be applied to re-stenotic area in the presence of stent or anastomosis sites. Recently, we have introduced microneedle cuff (MNC) as perivascular delivery devices to achieve high delivery efficiency to tunica media. In this study, we investigated in vivo microneedle insertion and efficacy in treating NH using a rabbit balloon injury model. Microneedle shape was optimized for reliable insertion into tunica media layer. Uniform distribution of PTX in tunica media delivered by MNC devices was also confirmed. Animal study demonstrated significant NH reduction by MNC treatments and much higher delivery efficiency than flat type devices.

Original languageEnglish
Pages (from-to)174-181
Number of pages8
JournalJournal of Controlled Release
Volume192
DOIs
Publication statusPublished - 2014 Oct 28

Fingerprint

Tunica Media
Neointima
Vascular System Injuries
Hyperplasia
Paclitaxel
Pharmaceutical Preparations
Equipment and Supplies
Blood Vessels
Vascular Grafting
Drug-Eluting Stents
Vascular Diseases
Smooth Muscle Myocytes
Stents
Rabbits
Wounds and Injuries
Therapeutics
Growth

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Lee, Kang Ju ; Park, Seung Hyun ; Lee, Ji Yong ; Joo, Hyun Chel ; Jang, Eui Hwa ; Youn, Young Nam ; Ryu, WonHyoung. / Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury. In: Journal of Controlled Release. 2014 ; Vol. 192. pp. 174-181.
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abstract = "Restenosis often occurs at the site of vascular grafting and may become fatal for patients. Restenosis at anastomosis sites is due to neointimal hyperplasia (NH) and difficult to treat with conventional treatments. Such abnormal growth of smooth muscle cells in tunica media of vascular tissue can be reduced by delivering anti-proliferation drugs such as paclitaxel (PTX) to the inner vascular layer. Drug eluting stents (DES) or drug eluting balloon (DEB) have been developed to treat such vascular diseases. However, they are less efficient in drug delivery due to the drug loss to blood stream and inadequate to be applied to re-stenotic area in the presence of stent or anastomosis sites. Recently, we have introduced microneedle cuff (MNC) as perivascular delivery devices to achieve high delivery efficiency to tunica media. In this study, we investigated in vivo microneedle insertion and efficacy in treating NH using a rabbit balloon injury model. Microneedle shape was optimized for reliable insertion into tunica media layer. Uniform distribution of PTX in tunica media delivered by MNC devices was also confirmed. Animal study demonstrated significant NH reduction by MNC treatments and much higher delivery efficiency than flat type devices.",
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Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury. / Lee, Kang Ju; Park, Seung Hyun; Lee, Ji Yong; Joo, Hyun Chel; Jang, Eui Hwa; Youn, Young Nam; Ryu, WonHyoung.

In: Journal of Controlled Release, Vol. 192, 28.10.2014, p. 174-181.

Research output: Contribution to journalArticle

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AU - Lee, Ji Yong

AU - Joo, Hyun Chel

AU - Jang, Eui Hwa

AU - Youn, Young Nam

AU - Ryu, WonHyoung

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