Perivascular Spaces in the Basal Ganglia and Long-term Motor Prognosis in Newly Diagnosed Parkinson Disease

Seok Jong Chung, Han Soo Yoo, Na Young Shin, Yae Won Park, Hye Sun Lee, Ji Man Hong, Yun Joong Kim, Seung Koo Lee, Phil Hyu Lee, Young H. Sohn

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the association between enlarged perivascular spaces (PVS) in the basal ganglia (BG-PVS) and long-term motor outcomes in Parkinson disease (PD). METHODS: We reviewed the medical records of 248 patients with drug-naive early-stage PD (follow-up >3 years, mean age 67.44 ± 8.46 years, 130 female) who underwent brain MRI and dopamine transporter (DAT) scans at initial assessment. The number of baseline enlarged BG-PVS was counted on axial T2-weighted images. Then, patients were divided into 2 groups: a PD group with a low number (0-10) of enlarged PVS (PD-EPVS-; n = 156) and a PD group with a high number (>10) of enlarged PVS (PD-EPVS+; n = 92). We used Cox regression models to compare the levodopa-induced dyskinesia (LID)-, wearing-off-, and freezing of gait (FOG)-free times between groups. We also compared longitudinal increases in levodopa-equivalent dose per body weight between groups using a linear mixed model. RESULTS: Patients in the PD-EPVS+ group were older (72.28 ± 6.07 years) and had greater small vessel disease burden than those in the PD-EPVS- group (64.58 ± 8.38 years). The PD-EPVS+ group exhibited more severely decreased DAT availability in all striatal subregions except the ventral striatum. The risk of FOG was higher in the PD-EPVS+ group, but the risk of LID or wearing-off was comparable between groups. The PD-EPVS+ group required higher doses of dopaminergic medications for effective symptom control compared to the PD-EPVS- group. CONCLUSION: This study suggests that baseline enlarged BG-PVS can be an indicator of the progression of motor disability in PD.

Original languageEnglish
Pages (from-to)e2121-e2131
JournalNeurology
Volume96
Issue number16
DOIs
Publication statusPublished - 2021 Apr 20

Bibliographical note

Publisher Copyright:
© 2021 American Academy of Neurology.

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Perivascular Spaces in the Basal Ganglia and Long-term Motor Prognosis in Newly Diagnosed Parkinson Disease'. Together they form a unique fingerprint.

Cite this