Permeability parameters measured with dynamic contrast-enhanced MRI: Correlation with the extravasation of evans blue in a rat model of transient cerebral ischemia

Hyun Seok Choi, Sung Soo Ahn, Na Young Shin, Jinna Kim, Jae Hyung Kim, Jong Eun Lee, Hye Yeon Lee, Ji Hoe Heo, Seung Koo Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. Materials and Methods: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (Ktrans, ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. Results: All permeability parameters (Ktrans, ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, Ktrans showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). Conclusion: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and Ktrans shows the strongest correlation among the tested parameters.

Original languageEnglish
Pages (from-to)791-797
Number of pages7
JournalKorean journal of radiology
Volume16
Issue number4
DOIs
Publication statusPublished - 2015 Aug 1

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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