Peroxidase-like oxidative activity of a manganese-coordinated histidyl bolaamphiphile self-assembly

Min Chul Kim, Sang Yup Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A peroxidase-like catalyst was constructed through the self-assembly of histidyl bolaamphiphiles coordinated to Mn2+ ions. The prepared catalyst exhibited oxidation activity for the organic substrate o-phenylenediamine (OPD) in the presence of hydrogen peroxide (H2O2). The histidyl bolaamphiphiles of bis(N-alpha-amido-histidine)-1,7-heptane dicarboxylates self-assembled to make spherical structures in an aqueous solution. Subsequent association of Mn2+ ions with the histidyl imidazoles in the self-assembly produced catalytic active sites. The optimal Mn2+ ion concentration was determined and coordination of the Mn2+ ion with multiple histidine imidazoles was investigated using spectroscopy analysis. The activation energy of the produced catalysts was 55.0 kJ mol-1, which was comparable to other peroxidase-mimetic catalysts. A detailed kinetics study revealed that the prepared catalyst followed a ping-pong mechanism and that the turnover reaction was promoted by increasing the substrate concentration. Finally, application of the prepared catalyst for glucose detection was demonstrated through cascade enzyme catalysis. This study demonstrated a facile way to prepare an enzyme-mimetic catalyst through the self-assembly of an amphiphilic molecule containing amino acid segments.

Original languageEnglish
Pages (from-to)17063-17070
Number of pages8
JournalNanoscale
Volume7
Issue number40
DOIs
Publication statusPublished - 2015 Oct 28

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Manganese
Self assembly
Peroxidase
Catalysts
Ions
Imidazoles
Histidine
Enzymes
Heptanes
Heptane
Substrates
bolaamphiphile
Hydrogen peroxide
Hydrogen Peroxide
Catalysis
Glucose
Amino acids
Activation energy
Association reactions
Spectroscopy

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

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abstract = "A peroxidase-like catalyst was constructed through the self-assembly of histidyl bolaamphiphiles coordinated to Mn2+ ions. The prepared catalyst exhibited oxidation activity for the organic substrate o-phenylenediamine (OPD) in the presence of hydrogen peroxide (H2O2). The histidyl bolaamphiphiles of bis(N-alpha-amido-histidine)-1,7-heptane dicarboxylates self-assembled to make spherical structures in an aqueous solution. Subsequent association of Mn2+ ions with the histidyl imidazoles in the self-assembly produced catalytic active sites. The optimal Mn2+ ion concentration was determined and coordination of the Mn2+ ion with multiple histidine imidazoles was investigated using spectroscopy analysis. The activation energy of the produced catalysts was 55.0 kJ mol-1, which was comparable to other peroxidase-mimetic catalysts. A detailed kinetics study revealed that the prepared catalyst followed a ping-pong mechanism and that the turnover reaction was promoted by increasing the substrate concentration. Finally, application of the prepared catalyst for glucose detection was demonstrated through cascade enzyme catalysis. This study demonstrated a facile way to prepare an enzyme-mimetic catalyst through the self-assembly of an amphiphilic molecule containing amino acid segments.",
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Peroxidase-like oxidative activity of a manganese-coordinated histidyl bolaamphiphile self-assembly. / Kim, Min Chul; Lee, Sang Yup.

In: Nanoscale, Vol. 7, No. 40, 28.10.2015, p. 17063-17070.

Research output: Contribution to journalArticle

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