Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats

Wan Seob Cho, Beom Seok Han, Byeongwoo Ahn, Ki Taek Nam, Mina Choi, Sang Yeon Oh, Seung Hee Kim, Jayoung Jeong, Dong Deuk Jang

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Abstract

Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-α activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalToxicology Letters
Volume178
Issue number2
DOIs
Publication statusPublished - 2008 May 5

All Science Journal Classification (ASJC) codes

  • Toxicology

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    Cho, W. S., Han, B. S., Ahn, B., Nam, K. T., Choi, M., Oh, S. Y., Kim, S. H., Jeong, J., & Jang, D. D. (2008). Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats. Toxicology Letters, 178(2), 110-116. https://doi.org/10.1016/j.toxlet.2008.02.013