Persistent drug-induced parkinsonism in patients with normal dopamine transporter imaging

Jin Yong Hong; Mun Kyung Sunwoo; Jungsu S. Oh; Jae Seung Kim; Young H. Sohn; Phil Hyu Lee

doi:10.1371/journal.pone.0157410

Persistent drug-induced parkinsonism in patients with normal dopamine transporter imaging

Jin Yong Hong, Mun Kyung Sunwoo, Jungsu S. Oh, Jae Seung Kim, Young H. Sohn, Phil Hyu Lee

Department of Neurology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish druginduced parkinsonism (DIP) from subclinical Parkinson's disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these patients showed changes in striatal DAT activity using semiquantitative analysis of ¹⁸F-FP-CIT PET data. DIP patients with visually normal DAT images were selected from medical records. The subjects were classified as patients who recovered partially (PR) or completely within 12 months (CR). The ¹⁸F-FP-CIT uptake in each striatal subregion was compared between the CR and the PR groups. In total, 41 and 9 patients of the CR and PR groups were assessed, respectively. The two patient groups were comparable in terms of clinical characteristics including age, sex, and severity of parkinsonism. From semi-quantitative analysis of the PET image, the PR patients showed a relatively lower ligand uptake in the ventral striatum, the anterior putamen and the posterior putamen compared with the CR patients. This result suggests that persistent DIP in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity.

Original language	English
Article number	e0157410
Journal	PloS one
Volume	11
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0157410
Publication status	Published - 2016 Jun

Bibliographical note

Funding Information:
This research was supported by the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (no. 2014M3C7A1064752). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2016 Hong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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title = "Persistent drug-induced parkinsonism in patients with normal dopamine transporter imaging",

abstract = "Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish druginduced parkinsonism (DIP) from subclinical Parkinson's disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these patients showed changes in striatal DAT activity using semiquantitative analysis of 18F-FP-CIT PET data. DIP patients with visually normal DAT images were selected from medical records. The subjects were classified as patients who recovered partially (PR) or completely within 12 months (CR). The 18F-FP-CIT uptake in each striatal subregion was compared between the CR and the PR groups. In total, 41 and 9 patients of the CR and PR groups were assessed, respectively. The two patient groups were comparable in terms of clinical characteristics including age, sex, and severity of parkinsonism. From semi-quantitative analysis of the PET image, the PR patients showed a relatively lower ligand uptake in the ventral striatum, the anterior putamen and the posterior putamen compared with the CR patients. This result suggests that persistent DIP in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity.",

author = "Hong, {Jin Yong} and Sunwoo, {Mun Kyung} and Oh, {Jungsu S.} and Kim, {Jae Seung} and Sohn, {Young H.} and Lee, {Phil Hyu}",

note = "Funding Information: This research was supported by the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (no. 2014M3C7A1064752). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2016 Hong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

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N2 - Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish druginduced parkinsonism (DIP) from subclinical Parkinson's disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these patients showed changes in striatal DAT activity using semiquantitative analysis of 18F-FP-CIT PET data. DIP patients with visually normal DAT images were selected from medical records. The subjects were classified as patients who recovered partially (PR) or completely within 12 months (CR). The 18F-FP-CIT uptake in each striatal subregion was compared between the CR and the PR groups. In total, 41 and 9 patients of the CR and PR groups were assessed, respectively. The two patient groups were comparable in terms of clinical characteristics including age, sex, and severity of parkinsonism. From semi-quantitative analysis of the PET image, the PR patients showed a relatively lower ligand uptake in the ventral striatum, the anterior putamen and the posterior putamen compared with the CR patients. This result suggests that persistent DIP in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity.

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Persistent drug-induced parkinsonism in patients with normal dopamine transporter imaging

Abstract

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