Persistent drug-induced parkinsonism in patients with normal dopamine transporter imaging

Jin Yong Hong, Mun Kyung Sunwoo, Jungsu S. Oh, Jae Seung Kim, Young H. Sohn, philhyu Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish druginduced parkinsonism (DIP) from subclinical Parkinson's disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these patients showed changes in striatal DAT activity using semiquantitative analysis of 18F-FP-CIT PET data. DIP patients with visually normal DAT images were selected from medical records. The subjects were classified as patients who recovered partially (PR) or completely within 12 months (CR). The 18F-FP-CIT uptake in each striatal subregion was compared between the CR and the PR groups. In total, 41 and 9 patients of the CR and PR groups were assessed, respectively. The two patient groups were comparable in terms of clinical characteristics including age, sex, and severity of parkinsonism. From semi-quantitative analysis of the PET image, the PR patients showed a relatively lower ligand uptake in the ventral striatum, the anterior putamen and the posterior putamen compared with the CR patients. This result suggests that persistent DIP in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity.

Original languageEnglish
Article numbere0157410
JournalPLoS One
Volume11
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1

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Dopamine Plasma Membrane Transport Proteins
Parkinsonian Disorders
dopamine
transporters
image analysis
Imaging techniques
drugs
Pharmaceutical Preparations
Corpus Striatum
Functional neuroimaging
Putamen
Functional Neuroimaging
Parkinson disease
Ligands
Medical Records
Parkinson Disease
quantitative analysis
Chemical analysis
gender

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Hong, Jin Yong ; Sunwoo, Mun Kyung ; Oh, Jungsu S. ; Kim, Jae Seung ; Sohn, Young H. ; Lee, philhyu. / Persistent drug-induced parkinsonism in patients with normal dopamine transporter imaging. In: PLoS One. 2016 ; Vol. 11, No. 6.
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Persistent drug-induced parkinsonism in patients with normal dopamine transporter imaging. / Hong, Jin Yong; Sunwoo, Mun Kyung; Oh, Jungsu S.; Kim, Jae Seung; Sohn, Young H.; Lee, philhyu.

In: PLoS One, Vol. 11, No. 6, e0157410, 01.06.2016.

Research output: Contribution to journalArticle

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